CAJ | 학술논문

随着生命科学的发展和医疗技术的进步,对心肌纤维化的干预甚至逆转已成为心脏病防治的新靶标.目前,心肌纤维化的检测临床常用心肌活组织检查和血清代谢物检测,但限制较多,不能完全满足临床需求.分子影像学技术可实现活体、无创、量化和靶向特异性评价心肌纤维化的有无、程度及转归,以便早期进行临床评估和干预.现阶段可用于心肌纤维化评价的分子影像技术主要包括SPECT、PET及MRI,不久的将来有望出现相应的分子影像探针用于心肌纤维化的超声靶向评价.
수착생명과학적발전화의료기술적진보,대심기섬유화적간예심지역전이성위심장병방치적신파표.목전,심기섬유화적검측림상상용심기활조직검사화혈청대사물검측,단한제교다,불능완전만족림상수구.분자영상학기술가실현활체、무창、양화화파향특이성평개심기섬유화적유무、정도급전귀,이편조기진행림상평고화간예.현계단가용우심기섬유화평개적분자영상기술주요포괄SPECT、PET급MRI,불구적장래유망출현상응적분자영상탐침용우심기섬유화적초성파향평개.
With the development of life science and medical technology,myocardial fibrosis is being increasingly recognized as a new therapeutic target for heart diseases.However,traditional methods for detection of myocardial fibrosis,such as myocardial biopsy and laboratory assay of serum metabolites or enzymes,are not satisfactory in meeting the clinical demands because of their intrinsic limitations.Molecular imaging may non-invasively and quantitatively evaluate the presence/absence,degree and turnover of myocardial fibrosis in vivo with good specificity,thus being useful for clinical assessment and intervention.Currently,the commonly used molecular imaging modalities for evaluation of myocardial fibrosis include SPECT,PET and MRI.It is hopeful that the molecular probe for targeted ultrasound technology may also be developed in the near future.This review highlights the current status and future trends of molecular imaging in myocardial fibrosis.