中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2009年
12期
908-910
,共3页
麦洪珍%王秋月%韩丽萍%康健%于润江
麥洪珍%王鞦月%韓麗萍%康健%于潤江
맥홍진%왕추월%한려평%강건%우윤강
肺疾病%慢性阻塞性%视黄醇结合蛋白质类%营养状况
肺疾病%慢性阻塞性%視黃醇結閤蛋白質類%營養狀況
폐질병%만성조새성%시황순결합단백질류%영양상황
Pulmonary disea:qe,chronic obstructive%Retinol-binding proteins%Nutritional status
目的 探讨COPD患者血清维生素A和视黄醇结合蛋白-4(RBP_4)水平及其与营养状况的关系.方法 2006年9月至2007年9月在中国医科大学附属第一医院门诊随访的110例COPD稳定期患者为COPD组,同期90例健康体检者为对照组,采用高效液相色谱法测定所有研究对象的血清维生素A水平,采用酶联免疫吸附试验检测COPD组中62例和对照组中20例的血清RBP_4水平.计数资料采用X~2检验,两组间均数比较采用t检验,多组间比较采用单因素方差分析及SNK-q检验,影响因素分析采用直线相关和多元逐步回归分析.结果 COPD组血清维生素A和RBP_4水平分别为(275±11)μg/L和(7.4±2.6)mg/L,明显低于对照组的(338±13)μg/L和(11.4±4.1)mg/L;COPD营养不良组血清维生素A和RBP_4水平分别为(246±18)μg/L和(6.4±1.0)mg/L,明显低于COPD营养正常组的(290±14)μg/L和(8.2±3.2)mg/L.COPD患者血清维生素A和RBP_4水平均与体重指数和上臂围呈显著正相关(r值为0.210～0.469,均P<0.05和P<0.01).体重指数和上臂围是COPD)患者血清维生素A的独立影响因素.结论 COPD稳定期患者血清维生素A和RBP_4水平均明显降低,营养状况是其主要影响因素.
目的 探討COPD患者血清維生素A和視黃醇結閤蛋白-4(RBP_4)水平及其與營養狀況的關繫.方法 2006年9月至2007年9月在中國醫科大學附屬第一醫院門診隨訪的110例COPD穩定期患者為COPD組,同期90例健康體檢者為對照組,採用高效液相色譜法測定所有研究對象的血清維生素A水平,採用酶聯免疫吸附試驗檢測COPD組中62例和對照組中20例的血清RBP_4水平.計數資料採用X~2檢驗,兩組間均數比較採用t檢驗,多組間比較採用單因素方差分析及SNK-q檢驗,影響因素分析採用直線相關和多元逐步迴歸分析.結果 COPD組血清維生素A和RBP_4水平分彆為(275±11)μg/L和(7.4±2.6)mg/L,明顯低于對照組的(338±13)μg/L和(11.4±4.1)mg/L;COPD營養不良組血清維生素A和RBP_4水平分彆為(246±18)μg/L和(6.4±1.0)mg/L,明顯低于COPD營養正常組的(290±14)μg/L和(8.2±3.2)mg/L.COPD患者血清維生素A和RBP_4水平均與體重指數和上臂圍呈顯著正相關(r值為0.210～0.469,均P<0.05和P<0.01).體重指數和上臂圍是COPD)患者血清維生素A的獨立影響因素.結論 COPD穩定期患者血清維生素A和RBP_4水平均明顯降低,營養狀況是其主要影響因素.
목적 탐토COPD환자혈청유생소A화시황순결합단백-4(RBP_4)수평급기여영양상황적관계.방법 2006년9월지2007년9월재중국의과대학부속제일의원문진수방적110례COPD은정기환자위COPD조,동기90례건강체검자위대조조,채용고효액상색보법측정소유연구대상적혈청유생소A수평,채용매련면역흡부시험검측COPD조중62례화대조조중20례적혈청RBP_4수평.계수자료채용X~2검험,량조간균수비교채용t검험,다조간비교채용단인소방차분석급SNK-q검험,영향인소분석채용직선상관화다원축보회귀분석.결과 COPD조혈청유생소A화RBP_4수평분별위(275±11)μg/L화(7.4±2.6)mg/L,명현저우대조조적(338±13)μg/L화(11.4±4.1)mg/L;COPD영양불량조혈청유생소A화RBP_4수평분별위(246±18)μg/L화(6.4±1.0)mg/L,명현저우COPD영양정상조적(290±14)μg/L화(8.2±3.2)mg/L.COPD환자혈청유생소A화RBP_4수평균여체중지수화상비위정현저정상관(r치위0.210～0.469,균P<0.05화P<0.01).체중지수화상비위시COPD)환자혈청유생소A적독립영향인소.결론 COPD은정기환자혈청유생소A화RBP_4수평균명현강저,영양상황시기주요영향인소.
Objective To explore the serum retinol and retinol binding protein-4 (RBP_4) levels in patients with chronic obstructive pulmonary disease (COPD) and to investigate their relationship with the nutritional status. Methods The serum retinol level was determined by high-performance liquid chromatography (HPLC) in 110 outpatients with stable COPD during Sept 2006 to Sept. 2007, and 90 healthy volunteers served as the controls. The serum RBP_4 level in 62 stable COPD outpatients and 20 healthy controls was measured by enzyme-linked immunosorbent assay ( ELISA ). Associated factors with the serum retinol and RBP_4 levels were analyzed, t-test and one-way ANOVA were used for the statistic analysis. Results The serum retinol and RBP_4 levels in COPD patients [ (275±11)μg/L and (7.4±2. 6) mg/Lrespectively] were significantly lower than those in the healthy controls[ (338±13)μg/L and (11.4±4. 1) mg/L respectively, t =3. 650, t =4. 155 and all P <0. 01 ]. The serum retinol and RBP_4 levels in COPD patients with malnutrition [ (246 ±18)μg/L and (6. 4 ± 1. 0) mg/L individually] were significantly lower than those in COPD patients without malnutrition [ (290 ±14) μg/L and (8. 2 ±3. 2) mg/L individually, q =3. 35 , P < 0. 05 and q = 10. 22, P < 0. 01 respectively ] , but the levels of serum retinol and RBP_4 in COPD patients without malnutrition were significantly lower than those in the healthy controls [ (338±13) μg/L and ( 11. 4 ±4. 1) mg/L respectively, q = 2. 26, P < 0. 05 and q = 4. 82, P < 0. 01 respectively ]. In a multiple stepwise regression analysis, only body mass index and mid arm circumference were independently associated with the serum retinal level. Conclusion In patients with stable COPD, the levels of serum retinol and RBP_4 were significantly decreased, which was associated with the nutritional status.
