CAJ | 학술논문

目的了解北京地区成人社区获得性肺炎(CAP)患者中肺炎支原体对大环内酯等常用抗生素的耐药情况.方法收集2010年9月至2012年6月北京地区3家医院就诊的CAP患者.采集咽拭子标本进行肺炎支原体培养.对分离到的肺炎支原体菌株进行体外药敏试验及对大环内酯类耐药相关基因突变位点检测.结果 321例患者纳入本研究,共分离出肺炎支原体53株,其中红霉素耐药38株(71.7％);阿奇霉素耐药32株(60.4％);未发现对喹诺酮及四环素类药物耐药的菌株.A2063G点突变是导致对大环内酯类抗生素耐药的主要点突变.结论北京地区成人CAP肺炎支原体对大环内酯类抗生素耐药率高,未发现喹诺酮及四环素类耐药菌株.
목적 료해북경지구성인사구획득성폐염(CAP)환자중폐염지원체대대배내지등상용항생소적내약정황.방법 수집2010년9월지2012년6월북경지구3가의원취진적CAP환자.채집인식자표본진행폐염지원체배양.대분리도적폐염지원체균주진행체외약민시험급대대배내지류내약상관기인돌변위점검측.결과 321례환자납입본연구,공분리출폐염지원체53주,기중홍매소내약38주(71.7％);아기매소내약32주(60.4％);미발현대규낙동급사배소류약물내약적균주.A2063G점돌변시도치대대배내지류항생소내약적주요점돌변.결론 북경지구성인CAP폐염지원체대대배내지류항생소내약솔고,미발현규낙동급사배소류내약균주.
Objective To explore the tendency of macrolide resistance in Mycoplasma pneumoniae infection in community-acquired pneumonia (CAP) patients in Beijing.Methods Adult CAP patients of ≥18 yrs were enrolled in 3 medical centers in Beijing,China.Throat swab samples were taken from all the patients to perform the culture of M.pneumoniae.All the isolated M.pneumoniae strains were subjected to susceptibility evaluation for 6 agents,including macrolides such as erythromycin and azithromycin.In strains showing macrolide resistance,the 23S rRNA gene was analyzed.Results A total 53 strains of M.pneumoniae were isolated from 321 enrolled patients.Thirty-eight of the isolated strains (71.7％) were resistant to erythromycin and 32 of them (60.4％) were resistant to azithromycin.Six strains with moderate or low level of erythromycin-resistance were still susceptible to azithromycin.No fluoroquinoloneresistant or tetracycline-resistant strains were observed in our study.Point transition of A2063G in the 23S ribosomal RNA gene was the main reason for the high prevalence of macrolide resistance.Conclusions The prevalence of macrolide resistance in M.pneumoniae is very high in adult CAP patients in Beijing.Studies are needed to clarify the clinical meaning of prevalence of macrolide-resistant M.pneamoniae in adults CAP patients.