中华健康管理学杂志
中華健康管理學雜誌
중화건강관이학잡지
CHINESE JOURNAL OF HEALTH MANAGEMENT
2010年
1期
35-38
,共4页
张兴华%杨金荣%付筱英%秦蕾%刘海燕%汪海霞%云霞%宋波%张旻
%Ellen He%Sven Skog
張興華%楊金榮%付篠英%秦蕾%劉海燕%汪海霞%雲霞%宋波%張旻
%Ellen He%Sven Skog
장흥화%양금영%부소영%진뢰%류해연%왕해하%운하%송파%장민
%Ellen He%Sven Skog
胸甘激酶%癌前状态%体格检查
胸甘激酶%癌前狀態%體格檢查
흉감격매%암전상태%체격검사
Thymidine kinase%Precancerous conditios%Physical examination
目的 研究血清胸苷激酶1(STK1)对癌前疾病癌变风险筛查的意义.方法 吉林油田总医院对8869例不同工种人群进行常规健康体检,包括平行检测STK1.该项目检测方法是采用高灵敏度点印迹免疫增强发光检测系统来检测STK1的浓度.依据STK1检测结果将人群分类讨论.结果 正常组8355例,STK1≤2 pmol/L,平均值(0.6±0.5)pmol/L;其中仅124例每项体检项目都正常占1.4%.风险组514例,STK1＞2 pmol/L,平均值(3.8±2.2)pmol/L,风险率为5.8%.癌前相关疾病可能恶变风险人数为85.2%(包括胆/肾息肉样病变增生,疑肝或肺恶瘤病灶,贫血疾病,肥胖,胆/肝/肺良性肿瘤,脂肪肝和乙肝阳性并伴有肝功能异常).发现STK1风险率升降与职业有一定相关性,第一类是长期、直接进行油田操作(钻井,运输,地质),总人数4333例,风险率7.8%;第二类是钻井前技术准备和服务(钻服,物探,钻技和测井),总人数4536例,风险率为3.9%,两类比较,第一类人群风险率有明显的升高(X2=55.53,P＜0.05),特别是息肉样病变增生和疑恶瘤病灶者主要发现在第一类,可能与直接、长期接触油田污染物有关.结论 胸苷激酶1是很有前景的血清标志物之一,它真实地反映了细胞异常增殖状况,使早期评估癌前疾病的癌变风险成为可能.
目的 研究血清胸苷激酶1(STK1)對癌前疾病癌變風險篩查的意義.方法 吉林油田總醫院對8869例不同工種人群進行常規健康體檢,包括平行檢測STK1.該項目檢測方法是採用高靈敏度點印跡免疫增彊髮光檢測繫統來檢測STK1的濃度.依據STK1檢測結果將人群分類討論.結果 正常組8355例,STK1≤2 pmol/L,平均值(0.6±0.5)pmol/L;其中僅124例每項體檢項目都正常佔1.4%.風險組514例,STK1＞2 pmol/L,平均值(3.8±2.2)pmol/L,風險率為5.8%.癌前相關疾病可能噁變風險人數為85.2%(包括膽/腎息肉樣病變增生,疑肝或肺噁瘤病竈,貧血疾病,肥胖,膽/肝/肺良性腫瘤,脂肪肝和乙肝暘性併伴有肝功能異常).髮現STK1風險率升降與職業有一定相關性,第一類是長期、直接進行油田操作(鑽井,運輸,地質),總人數4333例,風險率7.8%;第二類是鑽井前技術準備和服務(鑽服,物探,鑽技和測井),總人數4536例,風險率為3.9%,兩類比較,第一類人群風險率有明顯的升高(X2=55.53,P＜0.05),特彆是息肉樣病變增生和疑噁瘤病竈者主要髮現在第一類,可能與直接、長期接觸油田汙染物有關.結論 胸苷激酶1是很有前景的血清標誌物之一,它真實地反映瞭細胞異常增殖狀況,使早期評估癌前疾病的癌變風險成為可能.
목적 연구혈청흉감격매1(STK1)대암전질병암변풍험사사적의의.방법 길림유전총의원대8869례불동공충인군진행상규건강체검,포괄평행검측STK1.해항목검측방법시채용고령민도점인적면역증강발광검측계통래검측STK1적농도.의거STK1검측결과장인군분류토론.결과 정상조8355례,STK1≤2 pmol/L,평균치(0.6±0.5)pmol/L;기중부124례매항체검항목도정상점1.4%.풍험조514례,STK1＞2 pmol/L,평균치(3.8±2.2)pmol/L,풍험솔위5.8%.암전상관질병가능악변풍험인수위85.2%(포괄담/신식육양병변증생,의간혹폐악류병조,빈혈질병,비반,담/간/폐량성종류,지방간화을간양성병반유간공능이상).발현STK1풍험솔승강여직업유일정상관성,제일류시장기、직접진행유전조작(찬정,운수,지질),총인수4333례,풍험솔7.8%;제이류시찬정전기술준비화복무(찬복,물탐,찬기화측정),총인수4536례,풍험솔위3.9%,량류비교,제일류인군풍험솔유명현적승고(X2=55.53,P＜0.05),특별시식육양병변증생화의악류병조자주요발현재제일류,가능여직접、장기접촉유전오염물유관.결론 흉감격매1시흔유전경적혈청표지물지일,타진실지반영료세포이상증식상황,사조기평고암전질병적암변풍험성위가능.
Objective To investigate the role of serum thymidine kinase 1 ( STK1) in public screening for early carcinoma of precancerous diseases. Methods STK1 concentrations were measured in 8869 participants by using an enhanced chemiluminescent blot assay. Results The mean STK1 value (ra = 514) (5. 8% ) of the risk group (STK1 > 2 pmol/L) was (3. 8 ± 2. 2) pmol/L Only one individual with hepatoma was found. However, 85. 2% of the subjects in the risk group developed precancerous diseases (gall-bladder or kidney proliferative lesions), suspected liver or lung malignant tumor lesions, anemia disease,over-weight, benign tumor of gall-bladder, liver and lung, fatty liver and hepatitis B. Those (re = 4333) who had long-term direct exposure to oil-related pollutants (drilling, transportations, geological prospecting) showed a higher positive rate of STK1 (7. 8% ) in comparison to those (n =4536) responsible for pre-drilling prepared technology or services ( 3. 9% ) (χ2 = 55. 53, P < 0. 05 ). Furthermore, those who had proliferating lesions and suspected malignant tumor lesions were mainly found in the former group (78.4%), which might be associated with direct exposure to oil mists in the working environment. Conclusions Serum TK1 may be a reliable marker of tumor proliferating, enabling timely discovery of early carcinoma in patients with precancerous diseases.
