中华健康管理学杂志
中華健康管理學雜誌
중화건강관이학잡지
CHINESE JOURNAL OF HEALTH MANAGEMENT
2012年
6期
409-412
,共4页
刘晓丽%陆强%焦俊凤%王晓明%马春明%谢长顺%尹福在
劉曉麗%陸彊%焦俊鳳%王曉明%馬春明%謝長順%尹福在
류효려%륙강%초준봉%왕효명%마춘명%사장순%윤복재
代谢综合征X%肥胖症%胰岛素
代謝綜閤徵X%肥胖癥%胰島素
대사종합정X%비반증%이도소
Metabolic syndrome X%Obesity%Insulin
目的 探讨大学生谷草转氨酶(AST)/谷丙转氨酶(ALT)比值和代谢综合征(MS)之间的关系.方法 通过分层整群随机抽样的方法,选取秦皇岛市425名19 ～24岁大学生(男性216例,女性209例)作为研究对象,测量人体基本参数和空腹血糖(FPG)、血三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、ALT、AST及真胰岛素(TI)等代谢相关指标.按AST/ALT比值分为AST/ALT比值＜1组和AST/ALT比值≥1组.MS诊断参考ATPⅢ标准.结果 检测出AST/ALT比值＜1者146例(34.4％),调整年龄和性别后,AST/ALT比值与HDL-C呈正相关(r=0.125),与体重指数(BMI)(r=-0.281),腰围(WC)(r=-0.264),TG(r=-0.134),TI(r=-0.118)和胰岛素抵抗指数(HOMA-IR)(r=-0.121)呈负相关(P＜0.05).MS患病率为2.1％,男性和女性相似(2.3％和1.9％,x2=0.082,P=0.774).AST/ALT比值＜1组MS检出率明显高于AST/ALT比值≥1组(4.8％ vs.0.7％,P=0.016).调整年龄,性别和BMI后,大学生AST/ALT比值＜1组MS检出率为AST/ALT比值≥1组的6.975倍(95％ CI:1.430 ～ 34.019,P=0.016).结论 大学生AST/ALT比值与代谢综合征显著相关.
目的 探討大學生穀草轉氨酶(AST)/穀丙轉氨酶(ALT)比值和代謝綜閤徵(MS)之間的關繫.方法 通過分層整群隨機抽樣的方法,選取秦皇島市425名19 ～24歲大學生(男性216例,女性209例)作為研究對象,測量人體基本參數和空腹血糖(FPG)、血三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、ALT、AST及真胰島素(TI)等代謝相關指標.按AST/ALT比值分為AST/ALT比值＜1組和AST/ALT比值≥1組.MS診斷參攷ATPⅢ標準.結果 檢測齣AST/ALT比值＜1者146例(34.4％),調整年齡和性彆後,AST/ALT比值與HDL-C呈正相關(r=0.125),與體重指數(BMI)(r=-0.281),腰圍(WC)(r=-0.264),TG(r=-0.134),TI(r=-0.118)和胰島素牴抗指數(HOMA-IR)(r=-0.121)呈負相關(P＜0.05).MS患病率為2.1％,男性和女性相似(2.3％和1.9％,x2=0.082,P=0.774).AST/ALT比值＜1組MS檢齣率明顯高于AST/ALT比值≥1組(4.8％ vs.0.7％,P=0.016).調整年齡,性彆和BMI後,大學生AST/ALT比值＜1組MS檢齣率為AST/ALT比值≥1組的6.975倍(95％ CI:1.430 ～ 34.019,P=0.016).結論 大學生AST/ALT比值與代謝綜閤徵顯著相關.
목적 탐토대학생곡초전안매(AST)/곡병전안매(ALT)비치화대사종합정(MS)지간적관계.방법 통과분층정군수궤추양적방법,선취진황도시425명19 ～24세대학생(남성216례,녀성209례)작위연구대상,측량인체기본삼수화공복혈당(FPG)、혈삼선감유(TG)、고밀도지단백담고순(HDL-C)、ALT、AST급진이도소(TI)등대사상관지표.안AST/ALT비치분위AST/ALT비치＜1조화AST/ALT비치≥1조.MS진단삼고ATPⅢ표준.결과 검측출AST/ALT비치＜1자146례(34.4％),조정년령화성별후,AST/ALT비치여HDL-C정정상관(r=0.125),여체중지수(BMI)(r=-0.281),요위(WC)(r=-0.264),TG(r=-0.134),TI(r=-0.118)화이도소저항지수(HOMA-IR)(r=-0.121)정부상관(P＜0.05).MS환병솔위2.1％,남성화녀성상사(2.3％화1.9％,x2=0.082,P=0.774).AST/ALT비치＜1조MS검출솔명현고우AST/ALT비치≥1조(4.8％ vs.0.7％,P=0.016).조정년령,성별화BMI후,대학생AST/ALT비치＜1조MS검출솔위AST/ALT비치≥1조적6.975배(95％ CI:1.430 ～ 34.019,P=0.016).결론 대학생AST/ALT비치여대사종합정현저상관.
Objeetive To evaluate the relationship between aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT ratio) and metabolic syndrome in college students.Methods Anthropometric and metabolic measurements including fasting plasma glucose (FPG),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C),true insulin (TI),(AST and ALT) were assessed in a crosssectional study of 425 college students aged 19 to 24 years old (male 216,female 209) in 2009.The participants were then assigned to the AST/ALT ratio ＜ 1 group or the AST/ALT ratio ≥ 1 group.Metabolic syndrome was defined as Adult Treatment Panel Ⅲ criteria.Results AST/ALT ratio ＜ 1 was found in 146 subjects (34.4％).After adjustment for age and sex,AST/ALT ratio showed a positive correlation with HDLC (r=0.125) and negative correlations with body mass index (BMI,r=-0.281),waist circumtance (WC,r =-0.264),TG (r =-0.134),TI (r =-0.118) and HOMA-insulin resistance (HOMA-IR,r =-0.121) (all P ＜0.05).The prevalence of metabolic syndrome was 2.1％ and was similar in males and females (2.3％ vs.1.9％,P =0.774).Those with AST/ALT ratio ＜ 1 had a significantly higher prevalence of metabolic syndrome (4.8％ vs.0.7％,P =0.016).After adjustment for age,gender and BMI,the prevalence of metabolic syndrome of subjects with AST/ALT ratio ＜ 1 was nearly 7 (95％ CI:1.430 to 34.019,P =0.016) times of those with AST/ALT ratio ≥ 1.Conclusion AST/ALT ratio may be related with metabolic syndrome in college students.
