中华健康管理学杂志
中華健康管理學雜誌
중화건강관이학잡지
CHINESE JOURNAL OF HEALTH MANAGEMENT
2013年
2期
103-107
,共5页
胡滨%赵辉%冷松%刘颖%于书君%孙广慧%梁惠文
鬍濱%趙輝%冷鬆%劉穎%于書君%孫廣慧%樑惠文
호빈%조휘%랭송%류영%우서군%손엄혜%량혜문
尿酸%代谢综合征X%肱-踝脉搏波速度
尿痠%代謝綜閤徵X%肱-踝脈搏波速度
뇨산%대사종합정X%굉-과맥박파속도
Uric acid%Metabolic syndrome X%Branchial-ankle pulse wave velocity
目的 探讨不同性别健康体检人群血尿酸与肱-踝脉搏波速度(baPWV)的关系.方法 采用横断面研究的方法对1418例常规健康体检者收集生化指标,并测量baPWV.BaPWV≥1400 cm/s定义为baPWV异常.分别根据男女性血尿酸水平的四分位数,将人群分为4组(Q1、Q2、Q3和Q4组).Spearman相关分析不同性别血尿酸水平与baPWV的关系.在女性logistic回归分析血尿酸水平与baPWV异常的关系.结果 男性和女性均有舒张压、空腹血糖、三酰甘油和体质指数随血尿酸水平增高而增高；高密度脂蛋白-胆固醇随血尿酸水平增高而降低.女性收缩压、总胆固醇和低密度脂蛋白-胆固醇水平和baPWV水平亦随血尿酸增高而升高,差异有统计学意义.相关分析显示女性血尿酸与baPWV显著正相关(r=0.18,P ＜0.05),男性血尿酸与baPWV未见相关(r=-0.05,P=0.16).对女性人群单因素logistic分析结果表明,与血尿酸最低4分位组相比,最高4分位组baPWV异常的发病相对风险OR =2.69(95％ CI 1.68 ～4.29).在校正肌酐和估算肾小球滤过率后,血尿酸第4分位组相对第1分位组baPWV异常的相对风险OR=2.45(95％ CI 1.48 ～4.06).进一步用年龄和MS各组分校正后血尿酸与baPWV相关性消失0R=1.15(95％CI 0.56 ～ 2.37).结论 女性血尿酸水平与baPWV异常的相关依赖于年龄和MS的组分.
目的 探討不同性彆健康體檢人群血尿痠與肱-踝脈搏波速度(baPWV)的關繫.方法 採用橫斷麵研究的方法對1418例常規健康體檢者收集生化指標,併測量baPWV.BaPWV≥1400 cm/s定義為baPWV異常.分彆根據男女性血尿痠水平的四分位數,將人群分為4組(Q1、Q2、Q3和Q4組).Spearman相關分析不同性彆血尿痠水平與baPWV的關繫.在女性logistic迴歸分析血尿痠水平與baPWV異常的關繫.結果 男性和女性均有舒張壓、空腹血糖、三酰甘油和體質指數隨血尿痠水平增高而增高；高密度脂蛋白-膽固醇隨血尿痠水平增高而降低.女性收縮壓、總膽固醇和低密度脂蛋白-膽固醇水平和baPWV水平亦隨血尿痠增高而升高,差異有統計學意義.相關分析顯示女性血尿痠與baPWV顯著正相關(r=0.18,P ＜0.05),男性血尿痠與baPWV未見相關(r=-0.05,P=0.16).對女性人群單因素logistic分析結果錶明,與血尿痠最低4分位組相比,最高4分位組baPWV異常的髮病相對風險OR =2.69(95％ CI 1.68 ～4.29).在校正肌酐和估算腎小毬濾過率後,血尿痠第4分位組相對第1分位組baPWV異常的相對風險OR=2.45(95％ CI 1.48 ～4.06).進一步用年齡和MS各組分校正後血尿痠與baPWV相關性消失0R=1.15(95％CI 0.56 ～ 2.37).結論 女性血尿痠水平與baPWV異常的相關依賴于年齡和MS的組分.
목적 탐토불동성별건강체검인군혈뇨산여굉-과맥박파속도(baPWV)적관계.방법 채용횡단면연구적방법대1418례상규건강체검자수집생화지표,병측량baPWV.BaPWV≥1400 cm/s정의위baPWV이상.분별근거남녀성혈뇨산수평적사분위수,장인군분위4조(Q1、Q2、Q3화Q4조).Spearman상관분석불동성별혈뇨산수평여baPWV적관계.재녀성logistic회귀분석혈뇨산수평여baPWV이상적관계.결과 남성화녀성균유서장압、공복혈당、삼선감유화체질지수수혈뇨산수평증고이증고；고밀도지단백-담고순수혈뇨산수평증고이강저.녀성수축압、총담고순화저밀도지단백-담고순수평화baPWV수평역수혈뇨산증고이승고,차이유통계학의의.상관분석현시녀성혈뇨산여baPWV현저정상관(r=0.18,P ＜0.05),남성혈뇨산여baPWV미견상관(r=-0.05,P=0.16).대녀성인군단인소logistic분석결과표명,여혈뇨산최저4분위조상비,최고4분위조baPWV이상적발병상대풍험OR =2.69(95％ CI 1.68 ～4.29).재교정기항화고산신소구려과솔후,혈뇨산제4분위조상대제1분위조baPWV이상적상대풍험OR=2.45(95％ CI 1.48 ～4.06).진일보용년령화MS각조분교정후혈뇨산여baPWV상관성소실0R=1.15(95％CI 0.56 ～ 2.37).결론 녀성혈뇨산수평여baPWV이상적상관의뢰우년령화MS적조분.
Objective To determine the influence of gender on the association between serum uric acid and branchial-ankle pulse wave velocity (baPWV).Methods Cross-sectional data from 1418 adults who underwent routine laboratory tests and baPWV measurements were analyzed in a gender-specific manner.BaPWV≥ 1400 cm/s was defined as abnormality.The individuals were assigned to four groups (Q1,Q2,Q3 and Q4) according to the gender-specific quartiles of serum uric acid.The relationship between serum uric acid and the baPWV values was assessed by Spearman's correlation coefficients.In female,the relationship of serum uric acid quartiles with baPWV was evaluated by logistic regression analysis.Results In male and female,diastolic blood pressure,fasting blood glucose,triglyceride and body mass index were increased with serum uric acid level,in contrast to high-density lipoprotein cholesterol.The Spearman's correlation coefficient for the relationship between serum uric acid and baPWV was 0.18 in female and-0.05 in male (P =0.16).In female,univariate logistic regression analysis showed that in comparison with group Q1,odds ratio (OR) value of baPWV abnormality of group Q4 was 2.45 (95％confidence interval (CI) 1.48 to 4.06).In multivariate logistic regression,after adjusting for creatine and estimated glomerular filtration rate,OR value of baPWV abnormality of group Q4 was 2.45 (95％ CI 1.48 to 4.06) when compared with group Q1.However,after adjustment for age and other risk factors of cardiovascular diseases,there were no significant differents in ORs among serum uric acid quartile groups.Conclusions The association between serum uric acid level and baPWV in female may depend on age and metabolic syndrome components.
