中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
1期
17-20
,共4页
老年人%认知功能障碍%Klotho
老年人%認知功能障礙%Klotho
노년인%인지공능장애%Klotho
Aged%Cognitive impairment%Klotho
目的 比较新疆维吾尔自治区维吾尔族与汉族人群Klotho蛋白浓度的差异,探讨其与轻度认知功能障碍MCI的相关性.方法 采用分层、随机、多级整群抽样的方法,对新疆维吾尔自治区维吾尔族和汉族年龄≥60岁的老年常住居民进行MCI流行病学调查,纳入资料完整的MCI患者161例(MCI组;其中维吾尔族90例,汉族71例);选取民族、性别、年龄及血压相匹配的非MCI者161名(对照组;其中维吾尔族88名,汉族73名).采用酶联免疫吸附法检测2组血清Klotho蛋白的浓度,采用病例-对照方法进行Klotho蛋白浓度与MCI的相关性分析.结果 (1)MCI组Klotho蛋白浓度(2 480.12±1 379.05) ng/L显著低于对照组(3 070.34±1 390.53) ng/L(t =3.841,P＜0.05).(2)MCI组中汉族患者的Klotho蛋白浓度(2 810.35±1 417.74) ng/L显著低于对照组中的汉族对照者(3 341.87±1 375.47) ng/L(t =2.304,P＜0.05),MCI组中维吾尔族患者的Klotho蛋白浓度(2 215.37 ±1 297.67) ng/L显著低于对照组中的维吾尔族对照者(2 840.36±1 361.65) ng/L(t=3.134,P＜0.05);MCI组中维吾尔族患者的Klotho蛋白浓度显著低于MCI组中汉族患者(t=2.760,P＜0.05);对照组中维吾尔族对照者Klotho蛋白浓度显著低于对照组中汉族对照者(t=2.328,P＜0.05).(3)Klotho蛋白浓度与MMSE评分呈正相关(rs=0.209,P＜0.05),与年龄呈负相关(rs=-0.240,P＜0.05).结论 新疆维吾尔自治区维吾尔族人群Klotho蛋白浓度低于汉族人群;Klotho 蛋白含量可能与MCI的发病相关.
目的 比較新疆維吾爾自治區維吾爾族與漢族人群Klotho蛋白濃度的差異,探討其與輕度認知功能障礙MCI的相關性.方法 採用分層、隨機、多級整群抽樣的方法,對新疆維吾爾自治區維吾爾族和漢族年齡≥60歲的老年常住居民進行MCI流行病學調查,納入資料完整的MCI患者161例(MCI組;其中維吾爾族90例,漢族71例);選取民族、性彆、年齡及血壓相匹配的非MCI者161名(對照組;其中維吾爾族88名,漢族73名).採用酶聯免疫吸附法檢測2組血清Klotho蛋白的濃度,採用病例-對照方法進行Klotho蛋白濃度與MCI的相關性分析.結果 (1)MCI組Klotho蛋白濃度(2 480.12±1 379.05) ng/L顯著低于對照組(3 070.34±1 390.53) ng/L(t =3.841,P＜0.05).(2)MCI組中漢族患者的Klotho蛋白濃度(2 810.35±1 417.74) ng/L顯著低于對照組中的漢族對照者(3 341.87±1 375.47) ng/L(t =2.304,P＜0.05),MCI組中維吾爾族患者的Klotho蛋白濃度(2 215.37 ±1 297.67) ng/L顯著低于對照組中的維吾爾族對照者(2 840.36±1 361.65) ng/L(t=3.134,P＜0.05);MCI組中維吾爾族患者的Klotho蛋白濃度顯著低于MCI組中漢族患者(t=2.760,P＜0.05);對照組中維吾爾族對照者Klotho蛋白濃度顯著低于對照組中漢族對照者(t=2.328,P＜0.05).(3)Klotho蛋白濃度與MMSE評分呈正相關(rs=0.209,P＜0.05),與年齡呈負相關(rs=-0.240,P＜0.05).結論 新疆維吾爾自治區維吾爾族人群Klotho蛋白濃度低于漢族人群;Klotho 蛋白含量可能與MCI的髮病相關.
목적 비교신강유오이자치구유오이족여한족인군Klotho단백농도적차이,탐토기여경도인지공능장애MCI적상관성.방법 채용분층、수궤、다급정군추양적방법,대신강유오이자치구유오이족화한족년령≥60세적노년상주거민진행MCI류행병학조사,납입자료완정적MCI환자161례(MCI조;기중유오이족90례,한족71례);선취민족、성별、년령급혈압상필배적비MCI자161명(대조조;기중유오이족88명,한족73명).채용매련면역흡부법검측2조혈청Klotho단백적농도,채용병례-대조방법진행Klotho단백농도여MCI적상관성분석.결과 (1)MCI조Klotho단백농도(2 480.12±1 379.05) ng/L현저저우대조조(3 070.34±1 390.53) ng/L(t =3.841,P＜0.05).(2)MCI조중한족환자적Klotho단백농도(2 810.35±1 417.74) ng/L현저저우대조조중적한족대조자(3 341.87±1 375.47) ng/L(t =2.304,P＜0.05),MCI조중유오이족환자적Klotho단백농도(2 215.37 ±1 297.67) ng/L현저저우대조조중적유오이족대조자(2 840.36±1 361.65) ng/L(t=3.134,P＜0.05);MCI조중유오이족환자적Klotho단백농도현저저우MCI조중한족환자(t=2.760,P＜0.05);대조조중유오이족대조자Klotho단백농도현저저우대조조중한족대조자(t=2.328,P＜0.05).(3)Klotho단백농도여MMSE평분정정상관(rs=0.209,P＜0.05),여년령정부상관(rs=-0.240,P＜0.05).결론 신강유오이자치구유오이족인군Klotho단백농도저우한족인군;Klotho 단백함량가능여MCI적발병상관.
Objective To explore Klotho protein in the pathogenesis of mild cognitive impairment (MCI) in Uygur and Han nationalities in Xinjiang.Methods The stratified,random and multistage cluster sampling way was used in MCI epidemiological survey of the elderly residents aged 60 years or over in Xinjiang area,and 161 ones with MCI (Uygur nationality 90 cases,Han nationality 71 cases) and 161 healthy people matched with ethnic,gender and blood pressure were selected (Uygur nationality 88 people,Han nationality 73 people).ELISA was used to detect Klotho protein concentrations in serum.Results The concentration of Klotho protein in MCI group (2 480.12 ± 1 379.05) ng/L was lower than in control group (3 070.34 ± 1 390.53) ng/L (P ＜ 0.05).The concentration of Klotho protein in Han MCI persons (2 810.35 ± 1 417.74) ng/L was lower than Han control group(3 341.87 ± 1 375.47) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI persons (2 215.37 ± 1 297.67) ng/L was lower than Uygur control group(2 840.36 ± 1 361.65) ng/L(P ＜0.05).The concentration of Klotho protein in Uygur MCI group was lower than Han MCI group (P ＜ 0.05).At the same time,the concentration of Klotho protein of Uygur control group was lower than Han control group (P ＜ 0.05).The concentrations of Klotho protein was related to MMSE score(rs =0.209,P＜0.05) and age(rs =-0.240,P＜0.05).Conclusions The concentration of Klotho protein may be related to the pathogenesis of MCI.
