中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
1期
26-30
,共5页
杨帆%李培凯%侯瑜%元静%苏萍%卫芋君%康传媛%杨建中
楊帆%李培凱%侯瑜%元靜%囌萍%衛芋君%康傳媛%楊建中
양범%리배개%후유%원정%소평%위우군%강전원%양건중
精神分裂症%磁共振成像,弥散%各向异性分数
精神分裂癥%磁共振成像,瀰散%各嚮異性分數
정신분렬증%자공진성상,미산%각향이성분수
Schizophrenia%Diffusion magnetic resonance imaging%Fractional analysis
目的 探讨慢性精神分裂症脑白质磁共振弥散张量成像(diffusion tensor imaging,DTI)的特点及其与相关临床特征的关系.方法 收集慢性精神分裂症患者22例(疾病组)和健康志愿者16名(对照组),两组年龄、性别、受教育年限差异无统计学意义(P＞0.05),数据采集预处理后,采用独立样本t检验比较疾病组和对照组全脑白质各向异性分数(fractional analysis,FA)图像,并分析患者脑白质FA值与临床特征的相关性.结果 (1)疾病组较对照组FA增加的脑区域有:右颞中回(=4.64,P＜0.001);疾病组较对照组FA降低的脑区域有:左额下回(t=-5.41,P＜0.001),右颞上回(t=-4.57,P＜0.001),右颞横回(t=-4.30,P＜0.001),右海马回(t=-4.08,P＜0.001),左岛叶(t=-4.13 P＜0.001);(2)右颞上回(r=-0.538,P=0.01)、右颞横回(r=-0.507,P=0.016)、右海马回(r=-0.434,P=0.043)的FA值均与病程呈负相关.结论 慢性精神分裂症可能存在大脑白质纤维的异常;病程的长短可能与患者脑区异常有关,即病程越长,脑区异常越明显.
目的 探討慢性精神分裂癥腦白質磁共振瀰散張量成像(diffusion tensor imaging,DTI)的特點及其與相關臨床特徵的關繫.方法 收集慢性精神分裂癥患者22例(疾病組)和健康誌願者16名(對照組),兩組年齡、性彆、受教育年限差異無統計學意義(P＞0.05),數據採集預處理後,採用獨立樣本t檢驗比較疾病組和對照組全腦白質各嚮異性分數(fractional analysis,FA)圖像,併分析患者腦白質FA值與臨床特徵的相關性.結果 (1)疾病組較對照組FA增加的腦區域有:右顳中迴(=4.64,P＜0.001);疾病組較對照組FA降低的腦區域有:左額下迴(t=-5.41,P＜0.001),右顳上迴(t=-4.57,P＜0.001),右顳橫迴(t=-4.30,P＜0.001),右海馬迴(t=-4.08,P＜0.001),左島葉(t=-4.13 P＜0.001);(2)右顳上迴(r=-0.538,P=0.01)、右顳橫迴(r=-0.507,P=0.016)、右海馬迴(r=-0.434,P=0.043)的FA值均與病程呈負相關.結論 慢性精神分裂癥可能存在大腦白質纖維的異常;病程的長短可能與患者腦區異常有關,即病程越長,腦區異常越明顯.
목적 탐토만성정신분렬증뇌백질자공진미산장량성상(diffusion tensor imaging,DTI)적특점급기여상관림상특정적관계.방법 수집만성정신분렬증환자22례(질병조)화건강지원자16명(대조조),량조년령、성별、수교육년한차이무통계학의의(P＞0.05),수거채집예처리후,채용독립양본t검험비교질병조화대조조전뇌백질각향이성분수(fractional analysis,FA)도상,병분석환자뇌백질FA치여림상특정적상관성.결과 (1)질병조교대조조FA증가적뇌구역유:우섭중회(=4.64,P＜0.001);질병조교대조조FA강저적뇌구역유:좌액하회(t=-5.41,P＜0.001),우섭상회(t=-4.57,P＜0.001),우섭횡회(t=-4.30,P＜0.001),우해마회(t=-4.08,P＜0.001),좌도협(t=-4.13 P＜0.001);(2)우섭상회(r=-0.538,P=0.01)、우섭횡회(r=-0.507,P=0.016)、우해마회(r=-0.434,P=0.043)적FA치균여병정정부상관.결론 만성정신분렬증가능존재대뇌백질섬유적이상;병정적장단가능여환자뇌구이상유관,즉병정월장,뇌구이상월명현.
Objective To investigate the abnormality of white matter by diffusion tensor imaging (DTI) and correlation with clinical symptoms in chronic schizophrenia.Methods Twenty-two chronic schizophrenia patients and 16 age-,gender-and education-matched healthy controls were recruited.Correlation analysis was used to explore the relationship between abnormal brain regions and clinical symptoms of chronic schizophrenia.Results Compared with controls,patients had significant increased fractional analysis (FA) in right cerebrum middle temporal gyrus (t =4.64,P ＜ 0.001) and decreased FA in left cerebrum inferior frontal gyrus (t =-5.41,P ＜ 0.001),right cerebrum superior temporal gyrus (t =-4.57,P ＜0.001),right cerebrum transverse temporal gyrus (t =-4.30,P ＜ 0.001),right cerebrum hippocampal gyrus (t =-4.08 P ＜ 0.001),and left insular lobe (t =-4.13,P ＜ 0.001).The FA of right cerebrum superior temporal gyrus (r =-0.538,P =0.01),right cerebrum transverse temporal gyms (r =-0.507,P =0.016) and right cerebrum hippocampal gyrus (r =-0.434,P =0.043) had significantly negative correlation with illness duration.Conclusions Chronic schizophrenia patients might have white matter abnormalities.
