中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
1期
39-43
,共5页
杨春%巴华杰%余海鹰%赵汉清%过伟%高志勤
楊春%巴華傑%餘海鷹%趙漢清%過偉%高誌勤
양춘%파화걸%여해응%조한청%과위%고지근
主动攻击型人格障碍%微卫星重复%多态现象,遗传%病例对照研究
主動攻擊型人格障礙%微衛星重複%多態現象,遺傳%病例對照研究
주동공격형인격장애%미위성중복%다태현상,유전%병례대조연구
Personality disorders%Microsatellites repeats%Polymorphism,genetic%Case-control studies
目的 探讨主动攻击行为与相关短串联重复序列(short tandem repeats,STR)基因座Penta D、Penta E的关联情况.方法 运用PowerPlex(R) 16 HS System荧光标记复合扩增体系对307例主动攻击行为罪犯(研究组)与459名非攻击行为健康个体(对照组)样本进行PCR复合扩增,然后应用美国ABI3130XL型基因分析系统对扩增产物进行电泳和基因检测,观察2组Penta D、Penta E基因座等位基因及基因型频率的差异.结果 Penta D、Penta E基因座均符合遗传平衡定律(Hardy-Weinberg定律;均P＞0.05);2组Penta D、Penta E基因座等位基因及基因型频率分布差异有统计学意义(等位基因:P=0.000 0,P=0.001 3;基因型:P =0.001 2,P=0.000 0);单因素分析显示,2组在Penta D基因座等位基因5、6和Penta E基因座等位基因9的频率分布差异均有统计学意义(P=0.002 4,P=0.001 6,P=0.002 1),OR值分别为0.113(95％ CI:0.015 ～ 0.869)、12.092(95％ CI:1.506 ～96.924)、0.225 (95％ CI:0.078 ～0.648).结论 Penta D和Penta E基因座多态性与主动攻击行为的发生可能相关联;Penta D基因座的等位基因6可能为主动攻击行为发生的易感因素,PentaD基因座的等位基因5和Penta E基因座的等位基因9可能为主动攻击行为发生的抗性因素.
目的 探討主動攻擊行為與相關短串聯重複序列(short tandem repeats,STR)基因座Penta D、Penta E的關聯情況.方法 運用PowerPlex(R) 16 HS System熒光標記複閤擴增體繫對307例主動攻擊行為罪犯(研究組)與459名非攻擊行為健康箇體(對照組)樣本進行PCR複閤擴增,然後應用美國ABI3130XL型基因分析繫統對擴增產物進行電泳和基因檢測,觀察2組Penta D、Penta E基因座等位基因及基因型頻率的差異.結果 Penta D、Penta E基因座均符閤遺傳平衡定律(Hardy-Weinberg定律;均P＞0.05);2組Penta D、Penta E基因座等位基因及基因型頻率分佈差異有統計學意義(等位基因:P=0.000 0,P=0.001 3;基因型:P =0.001 2,P=0.000 0);單因素分析顯示,2組在Penta D基因座等位基因5、6和Penta E基因座等位基因9的頻率分佈差異均有統計學意義(P=0.002 4,P=0.001 6,P=0.002 1),OR值分彆為0.113(95％ CI:0.015 ～ 0.869)、12.092(95％ CI:1.506 ～96.924)、0.225 (95％ CI:0.078 ～0.648).結論 Penta D和Penta E基因座多態性與主動攻擊行為的髮生可能相關聯;Penta D基因座的等位基因6可能為主動攻擊行為髮生的易感因素,PentaD基因座的等位基因5和Penta E基因座的等位基因9可能為主動攻擊行為髮生的抗性因素.
목적 탐토주동공격행위여상관단천련중복서렬(short tandem repeats,STR)기인좌Penta D、Penta E적관련정황.방법 운용PowerPlex(R) 16 HS System형광표기복합확증체계대307례주동공격행위죄범(연구조)여459명비공격행위건강개체(대조조)양본진행PCR복합확증,연후응용미국ABI3130XL형기인분석계통대확증산물진행전영화기인검측,관찰2조Penta D、Penta E기인좌등위기인급기인형빈솔적차이.결과 Penta D、Penta E기인좌균부합유전평형정률(Hardy-Weinberg정률;균P＞0.05);2조Penta D、Penta E기인좌등위기인급기인형빈솔분포차이유통계학의의(등위기인:P=0.000 0,P=0.001 3;기인형:P =0.001 2,P=0.000 0);단인소분석현시,2조재Penta D기인좌등위기인5、6화Penta E기인좌등위기인9적빈솔분포차이균유통계학의의(P=0.002 4,P=0.001 6,P=0.002 1),OR치분별위0.113(95％ CI:0.015 ～ 0.869)、12.092(95％ CI:1.506 ～96.924)、0.225 (95％ CI:0.078 ～0.648).결론 Penta D화Penta E기인좌다태성여주동공격행위적발생가능상관련;Penta D기인좌적등위기인6가능위주동공격행위발생적역감인소,PentaD기인좌적등위기인5화Penta E기인좌적등위기인9가능위주동공격행위발생적항성인소.
Objective To investigate the relationship of the initiative-aggressive behaviors and short tandem repeats (STRs) loci Penta D and Penta E.Methods The biological samples of 307 initiativeaggressive violent offenders and 459 healthy persons without violent behavior were collected.Then all of the sample were amplified by PowerPlex(R) 16 HS System and separated by electrophoresis to compare the genotypes and alleles frequency of Penta D and Penta E in both groups.Results Penta D and Penta E loci in both groups were found to coincide with Hardy-Weinberg equilibrium(P ＞0.05).There were significant difference of alleles and genotypes frequency at loci Penta D and Penta E between both groups (alleles:P =0.000 0,P =0.001 3; genotypes:P =0.001 2; P =0.000 0).Univarite analysis showed significant differences at allelle 5,6 on Penta D and allelle 9 on Penta E between both groups (P =0.002 4,P =0.001 6,P =0.002 1),with the OR values being 0.113 (95％ CI:0.015-0.869),12.092 (95 ％ CI:1.506-96.924),0.225 (95％ CI:0.078-0.648),respectively.Conclusion Penta D and Penta E might be associated with initiative-aggressive behavior,with allelle 6 on Penta D being the susceptible factor and allelle 5 on Penta D and allelle 9 on Penta E might being the protective factors.
