中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
2期
74-78
,共5页
吕钦谕%马连华%刘传军%胡国芹%李君%张晨%卢卫红%禹顺英%易正辉
呂欽諭%馬連華%劉傳軍%鬍國芹%李君%張晨%盧衛紅%禹順英%易正輝
려흠유%마련화%류전군%호국근%리군%장신%로위홍%우순영%역정휘
精神分裂症%酪氨酸羟化酶基因%多态性,单核苷酸
精神分裂癥%酪氨痠羥化酶基因%多態性,單覈苷痠
정신분렬증%락안산간화매기인%다태성,단핵감산
Schizophrenia%Tyrosine hydroxylase gene%Polymorphism,single nucleotide
目的 探讨中国汉族人群酪氨酸羟化酶(tyrosine hydroxylase,TH)基因多态性与早发精神分裂症的关联性.方法 采用TaqMan荧光探针基因分型技术,检测315例早发精神分裂症患者(患者组,起病年龄＜18岁)和391名健康对照(对照组)TH基因标签单核苷酸多态性rs2070762、rs6356及rs11042978 3个多态位点,并对等位基因、基因型及单体型频率进行比较.结果 (1)患者组与对照组单位点分析显示,rs2070762[x2=1.12,自由度(df)=1,P=0.290;x2 =1.75,df=2,P=0.417]及rs6356(x2=1.71,df=1,P=0.190;x2=2.86,df=2,P=0.239)等位基因和基因型分布差异无统计学意义.rs11042978等位基因分布和基因型分布的差异有统计学意义(x2=4.47,df=1,P =0.034;x2=6.35,df=2,P=0.042),但经Bonferroni校正检验后,差异无统计学意义(P＞0.05);(2)单体型分析显示,患者组与对照组比较,由rs2070762-rs6356-rs11042978组成的单体型A-C-G,差异有统计学意义(x2=6.35,P=0.012),但经Permutation校正检验后,差异无统计学意义(x2=4.84,P=0.104).结论 在中国汉族人群中酪氨酸羟化酶基因可能不是早发精神分裂症的易患基因.
目的 探討中國漢族人群酪氨痠羥化酶(tyrosine hydroxylase,TH)基因多態性與早髮精神分裂癥的關聯性.方法 採用TaqMan熒光探針基因分型技術,檢測315例早髮精神分裂癥患者(患者組,起病年齡＜18歲)和391名健康對照(對照組)TH基因標籤單覈苷痠多態性rs2070762、rs6356及rs11042978 3箇多態位點,併對等位基因、基因型及單體型頻率進行比較.結果 (1)患者組與對照組單位點分析顯示,rs2070762[x2=1.12,自由度(df)=1,P=0.290;x2 =1.75,df=2,P=0.417]及rs6356(x2=1.71,df=1,P=0.190;x2=2.86,df=2,P=0.239)等位基因和基因型分佈差異無統計學意義.rs11042978等位基因分佈和基因型分佈的差異有統計學意義(x2=4.47,df=1,P =0.034;x2=6.35,df=2,P=0.042),但經Bonferroni校正檢驗後,差異無統計學意義(P＞0.05);(2)單體型分析顯示,患者組與對照組比較,由rs2070762-rs6356-rs11042978組成的單體型A-C-G,差異有統計學意義(x2=6.35,P=0.012),但經Permutation校正檢驗後,差異無統計學意義(x2=4.84,P=0.104).結論 在中國漢族人群中酪氨痠羥化酶基因可能不是早髮精神分裂癥的易患基因.
목적 탐토중국한족인군락안산간화매(tyrosine hydroxylase,TH)기인다태성여조발정신분렬증적관련성.방법 채용TaqMan형광탐침기인분형기술,검측315례조발정신분렬증환자(환자조,기병년령＜18세)화391명건강대조(대조조)TH기인표첨단핵감산다태성rs2070762、rs6356급rs11042978 3개다태위점,병대등위기인、기인형급단체형빈솔진행비교.결과 (1)환자조여대조조단위점분석현시,rs2070762[x2=1.12,자유도(df)=1,P=0.290;x2 =1.75,df=2,P=0.417]급rs6356(x2=1.71,df=1,P=0.190;x2=2.86,df=2,P=0.239)등위기인화기인형분포차이무통계학의의.rs11042978등위기인분포화기인형분포적차이유통계학의의(x2=4.47,df=1,P =0.034;x2=6.35,df=2,P=0.042),단경Bonferroni교정검험후,차이무통계학의의(P＞0.05);(2)단체형분석현시,환자조여대조조비교,유rs2070762-rs6356-rs11042978조성적단체형A-C-G,차이유통계학의의(x2=6.35,P=0.012),단경Permutation교정검험후,차이무통계학의의(x2=4.84,P=0.104).결론 재중국한족인군중락안산간화매기인가능불시조발정신분렬증적역환기인.
Objective To investigate the relationship between the tyrosine hydroxylase (TH) gene and early-onset schizophrenia in Chinese Han population.Metbods The tag single nucleotide polymorphisms (tag SNPs) rs2070762,rs6356 and rs11042978 in the TH gene were genotyped in 315 earlyonset schizophrenics (188 male patients,127 female patients) and 391 controls subjects (219 males,172 females).Single nucleotide polymorphism association and haplotype analysis were performed.Results (1) No statistically significant differences were found in allele or genotype between patients and normal controls for rs2070762 (x2 =1.12,df =1,P =0.290 ; x2 =1.75,df =2,P =0.417) and rs6356 (x2 =1.71,df=1,P =0.190 ; x2 =2.86,df =2,P =0.239).There were significant differences in allele and genotype frequencies between patients and normal control for rs11042978 allele (x2 =4.47,df =1,P =0.034) and genotype (x2 =6.35,df =2,P =0.042),but the difference did not existed after Bonferroni correction in allele frequencies (P ＞ 0.05).(2) The analysis revealed that there were significant differences between patients and normal control subjects for haplotypes A-C-G of rs2070762-rs6356-rs11042978 (x2 =6.35,P =0.012),but the difference did not existed after Permutation test in haplotype frequencies(x2 =4.84,P =0.104).Conclusions The TH gene may not play major roles in the susceptibility to early-onset schizophrenia in Chinese population.
