中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
2期
84-89
,共6页
张芸%明庆森%朱熊兆%蚁金瑶%姚树桥
張蕓%明慶森%硃熊兆%蟻金瑤%姚樹橋
장예%명경삼%주웅조%의금요%요수교
单胺氧化酶%多态性,单核苷酸%虐待儿童%攻击
單胺氧化酶%多態性,單覈苷痠%虐待兒童%攻擊
단알양화매%다태성,단핵감산%학대인동%공격
Monoamine oxidase%Polymorphism single nucleotide%Child abuse%Aggression
目的 探讨单胺氧化酶A串联重复序列(monoamine oxidase A variable number of tandem repeats)基因多态性及儿童期虐待对中国青少年攻击行为影响.方法 采用整群随机抽样法抽取某中学637名年龄13～18岁汉族青少年样本(男388名,女249名),采用儿童创伤经历问卷评定儿童期虐待,采用儿童行为量表评定攻击行为,并从研究对象外周静脉血提取DNA进行MAOA-VNTR基因分型,采用直线回归方法检验儿童期虐待和MAOA-VNTR基因多态性各自对攻击行为的主效应及两者间的交互作用.结果 共有513名(男367名,女146名)进入研究,男性攻击行为平均得分(10.13±6.67)分,女性攻击行为平均得分(9.18 ±6.36)分,不同性别间攻击行为差异无统计学意义(P=0.08).367名男性青少年被试中,MAOA低、高活性组分别为58.3％与41.7％,且不同组间攻击行为得分差异无统计学意义(P=0.93).回归模型显示MAOA基因型对男性青少年攻击行为无预测作用,儿童期虐待经历对攻击行为有显著预测作用(P＜0.01),且MAOA基因型与不同类型童年虐待对攻击行为存在显著交互作用(MAOA×虐待总分:P ＜0.01;MAOA×躯体虐待:P=0.02;MAOA×情感虐待:P ＜0.01;MAOA×性虐待:P =0.04),MAOA低活性男性在经历儿童期躯体虐待和情感虐待后更易出现攻击倾向;146名女性青少年被试中,MAOA低活性、高活性及杂合子组分别占39.4％、22.5％和38.1％,MAOA不同基因型之间攻击行为得分差异无统计学意义(P=0.69).回归模型显示MAOA基因型对女性青少年攻击行为无预测作用,但儿童期虐待经历对其有显著预测作用(P＜0.01),且MAOA与性虐待及MAOA与情感虐待对攻击行为分别存在交互作用(P值分别为0.03和0.04),MAOA低活性女性在受到儿童期性虐待/情感虐待后更易出现攻击倾向.结论 我国13 ～18岁青少年攻击行为受到儿童期虐待经历与MAOA-VNTR基因-环境间交互作用的影响,且不同性别青少年对不同虐待类型存在敏感性差异.
目的 探討單胺氧化酶A串聯重複序列(monoamine oxidase A variable number of tandem repeats)基因多態性及兒童期虐待對中國青少年攻擊行為影響.方法 採用整群隨機抽樣法抽取某中學637名年齡13～18歲漢族青少年樣本(男388名,女249名),採用兒童創傷經歷問捲評定兒童期虐待,採用兒童行為量錶評定攻擊行為,併從研究對象外週靜脈血提取DNA進行MAOA-VNTR基因分型,採用直線迴歸方法檢驗兒童期虐待和MAOA-VNTR基因多態性各自對攻擊行為的主效應及兩者間的交互作用.結果 共有513名(男367名,女146名)進入研究,男性攻擊行為平均得分(10.13±6.67)分,女性攻擊行為平均得分(9.18 ±6.36)分,不同性彆間攻擊行為差異無統計學意義(P=0.08).367名男性青少年被試中,MAOA低、高活性組分彆為58.3％與41.7％,且不同組間攻擊行為得分差異無統計學意義(P=0.93).迴歸模型顯示MAOA基因型對男性青少年攻擊行為無預測作用,兒童期虐待經歷對攻擊行為有顯著預測作用(P＜0.01),且MAOA基因型與不同類型童年虐待對攻擊行為存在顯著交互作用(MAOA×虐待總分:P ＜0.01;MAOA×軀體虐待:P=0.02;MAOA×情感虐待:P ＜0.01;MAOA×性虐待:P =0.04),MAOA低活性男性在經歷兒童期軀體虐待和情感虐待後更易齣現攻擊傾嚮;146名女性青少年被試中,MAOA低活性、高活性及雜閤子組分彆佔39.4％、22.5％和38.1％,MAOA不同基因型之間攻擊行為得分差異無統計學意義(P=0.69).迴歸模型顯示MAOA基因型對女性青少年攻擊行為無預測作用,但兒童期虐待經歷對其有顯著預測作用(P＜0.01),且MAOA與性虐待及MAOA與情感虐待對攻擊行為分彆存在交互作用(P值分彆為0.03和0.04),MAOA低活性女性在受到兒童期性虐待/情感虐待後更易齣現攻擊傾嚮.結論 我國13 ～18歲青少年攻擊行為受到兒童期虐待經歷與MAOA-VNTR基因-環境間交互作用的影響,且不同性彆青少年對不同虐待類型存在敏感性差異.
목적 탐토단알양화매A천련중복서렬(monoamine oxidase A variable number of tandem repeats)기인다태성급인동기학대대중국청소년공격행위영향.방법 채용정군수궤추양법추취모중학637명년령13～18세한족청소년양본(남388명,녀249명),채용인동창상경력문권평정인동기학대,채용인동행위량표평정공격행위,병종연구대상외주정맥혈제취DNA진행MAOA-VNTR기인분형,채용직선회귀방법검험인동기학대화MAOA-VNTR기인다태성각자대공격행위적주효응급량자간적교호작용.결과 공유513명(남367명,녀146명)진입연구,남성공격행위평균득분(10.13±6.67)분,녀성공격행위평균득분(9.18 ±6.36)분,불동성별간공격행위차이무통계학의의(P=0.08).367명남성청소년피시중,MAOA저、고활성조분별위58.3％여41.7％,차불동조간공격행위득분차이무통계학의의(P=0.93).회귀모형현시MAOA기인형대남성청소년공격행위무예측작용,인동기학대경력대공격행위유현저예측작용(P＜0.01),차MAOA기인형여불동류형동년학대대공격행위존재현저교호작용(MAOA×학대총분:P ＜0.01;MAOA×구체학대:P=0.02;MAOA×정감학대:P ＜0.01;MAOA×성학대:P =0.04),MAOA저활성남성재경력인동기구체학대화정감학대후경역출현공격경향;146명녀성청소년피시중,MAOA저활성、고활성급잡합자조분별점39.4％、22.5％화38.1％,MAOA불동기인형지간공격행위득분차이무통계학의의(P=0.69).회귀모형현시MAOA기인형대녀성청소년공격행위무예측작용,단인동기학대경력대기유현저예측작용(P＜0.01),차MAOA여성학대급MAOA여정감학대대공격행위분별존재교호작용(P치분별위0.03화0.04),MAOA저활성녀성재수도인동기성학대/정감학대후경역출현공격경향.결론 아국13 ～18세청소년공격행위수도인동기학대경력여MAOA-VNTR기인-배경간교호작용적영향,차불동성별청소년대불동학대류형존재민감성차이.
Objective The association of MAOA-VNTR monoamine oxidase A variable number of tandem repeats genotype and child abuse on aggressive behavior among Chinese Han adolescents were examined.Methods A group of 513 (M:367,F:146) 13-18 years old Chinese adolescents were selected randomly,and the effects of child maltreatment [measured using the child trauma questionnaire (CTQ)]and aggressive behavior during adolescents' period [assessed by the Child Behavior Checklist for Youth SelfReport (YSR)] were examined respectively.DNA were collected and MAOA-VNTR genotype were assessed via venous blood sample.Both the main effects of MAOA genotype,children's maltreatment experience and the interaction between them were analyzed by a linear regression analysis.Results In all,513 middle school students (367 boys,146 girls) were analyzed in the study.The mean aggression scores were (10.13 ±6.67)and (9.18 ± 6.36) for boys and girls.The low and high activity of MAOA-VNTR genotype accounts for 58.3％ and 41.7％ for boys,and 39.4％ and 22.5％ for girls respectively.The GLM model showed that there were no direct association between the MAOA genotypes with aggression scores,while a significant association between children's maltreatment experience with aggressive behavior in adolescents' period were found for both boys and girls (P ＜ 0.01).Some significant interactions between MAOA genotype with subtypes of maltreatment were uncovered (boys:P =0.02,P ＜0.01 and P =0.04 for MAOA with physical abuse,emotional abuse and sexual abuse; girls:P =0.03 and P =0.04 for MAOA with sexual and emotional abuse).For adolescents with the low activity of MAOA-VNTR were more prone to commit aggressive behavior when suffered children's abuse for both gender.Conclusions Aggressive behaviors among Chinese adolescents may be affected by a gene-enviornment interaction involving MAOA-VNTR and children's abuse experience which may be differentially sensitive to the subtype of childhood maltreatment and gender.
