CAJ | 학술논문

目的探讨中青年女性抑郁症患者脑区自发性活动特征及与症状严重程度的相关性.方法对14例女性抑郁症患者(患者组)和18名相匹配的健康对照者(对照组),进行3.0T静息态功能磁共振扫描.比较两组被试者脑区低频振幅值,将差异有统计学意义的脑区低频振幅均值与症状严重程度进行相关分析.结果患者组较对照组右小脑前叶[蒙特利尔神经病学研究所(MNI)坐标(x,y,z):39,-54,-36,k=20]低频振幅值增高(t=3.678,P＜0.05),左后扣带回[MNI坐标(x,y,z):-6,-45,15,k=18]、左顶上小叶[MNI坐标(x,y,z):-21,-78,48,k=20]低频振幅值降低(t=-3.967、-3.669,均P＜0.05,Alphasim矫正).Pearson相关分析显示右小脑前叶低频振幅值与发作次数呈正相关(r =0.607,P=0.021),与17项HAMD总分(r=-0.595,P=0.025)和认知障碍因子分(r=-0.542,P=0.045)呈负相关.结论女性抑郁症患者存在静息态脑区局部神经元活动异常,其程度可能与症状严重程度及认知损害相关.
목적 탐토중청년녀성억욱증환자뇌구자발성활동특정급여증상엄중정도적상관성.방법 대14례녀성억욱증환자(환자조)화18명상필배적건강대조자(대조조),진행3.0T정식태공능자공진소묘.비교량조피시자뇌구저빈진폭치,장차이유통계학의의적뇌구저빈진폭균치여증상엄중정도진행상관분석.결과 환자조교대조조우소뇌전협[몽특리이신경병학연구소(MNI)좌표(x,y,z):39,-54,-36,k=20]저빈진폭치증고(t=3.678,P＜0.05),좌후구대회[MNI좌표(x,y,z):-6,-45,15,k=18]、좌정상소협[MNI좌표(x,y,z):-21,-78,48,k=20]저빈진폭치강저(t=-3.967、-3.669,균P＜0.05,Alphasim교정).Pearson상관분석현시우소뇌전협저빈진폭치여발작차수정정상관(r =0.607,P=0.021),여17항HAMD총분(r=-0.595,P=0.025)화인지장애인자분(r=-0.542,P=0.045)정부상관.결론 녀성억욱증환자존재정식태뇌구국부신경원활동이상,기정도가능여증상엄중정도급인지손해상관.
Objective To explore energy feature of the spontaneous neural activity in young female depressive patients,and its correlation to the severity of depressive symptoms.Methods Fourteen female depressive patients and 18 healthy controls were scanned with 3.0 T MRI scanner.The difference with amplitude of low frequency fluctuation (ALFF) between both groups was compared with the t-test,and the correlation analysis between ALFF of brain regions with significant difference and the severity of depressive symptoms was conducted.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right cerebellum anterior lobe (Montreal Neurological Institute(MNI) coordinates (x,y,z):39,-54,-36; k =20; t=3.678,P ＜ 0.05),and decreased ALFF in the left posterior cingulate (MNI coordinates (x,y,z):-6,-45,15; k =18) and the left superior parietal lobule (MNI coordinates (x,y,z):-21,-78,48; k =20;t =-3.967,-3.669; both P ＜0.05; corrected by Alphasim).The ALFF in the right cerebellum anterior lobe was positively correlated to the number of depressive episodes (r=0.607,P =0.021),and negatively correlated to the HAMD17 total score and cognitive disturbance score (r =-0.595,P =0.025 ; r =-0.542,P =0.045,respectively).Conclusion Abnormal brain activity could emerge in female depressive patients during resting-state,the level of ALFF may be associated with severity of depressive symptoms and cognitive disturbance.