中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
4期
205-211
,共7页
沈宗霖%莫茵%李娜%刘芳%卢瑾%陈伟%许秀峰%程宇琪
瀋宗霖%莫茵%李娜%劉芳%盧瑾%陳偉%許秀峰%程宇琪
침종림%막인%리나%류방%로근%진위%허수봉%정우기
抑郁症%事件相关电位,P300%灰质体积%磁共振成像
抑鬱癥%事件相關電位,P300%灰質體積%磁共振成像
억욱증%사건상관전위,P300%회질체적%자공진성상
Major depressive disorder%Event-related potentials,P300%Gray matter volume%Magnetic resonance imaging
目的 探讨首次发病未服药女性抑郁症患者脑灰质体积变化特点,以及与认知事件相关电位P300的相关分析.方法 对25例18 ～58岁首次发病未服药女性抑郁症患者(患者组)和28名健康对照者(对照组)行头部3D结构MRI扫描,并对患者组进行P300检查.结果 患者组较对照组右侧额下回岛盖部、右侧中央前回灰质体积减小.患者组中P3、N2潜伏期均与双侧壳核、右侧颞中回体积呈正相关(均P ＜0.01);P3潜伏期与左侧颞中回、左侧额中回、左侧梭状回体积呈正相关(均P＜0.01),而P3波幅与左侧角回、右侧额上回体积呈负相关(均P＜0.01);N2潜伏期与左侧后扣带回、右侧梭状回、枕叶、左侧小脑体积呈正相关(均P＜0.01);患者组P300潜伏期和波幅与汉密尔顿抑郁量表的总分和各因子分无相关性.结论 首次发病未服药女性抑郁症患者存在特征性脑灰质体积异常,其P300可能与多个脑灰质区域相关,尤其与颞叶、基底神经节的关系最明显.
目的 探討首次髮病未服藥女性抑鬱癥患者腦灰質體積變化特點,以及與認知事件相關電位P300的相關分析.方法 對25例18 ～58歲首次髮病未服藥女性抑鬱癥患者(患者組)和28名健康對照者(對照組)行頭部3D結構MRI掃描,併對患者組進行P300檢查.結果 患者組較對照組右側額下迴島蓋部、右側中央前迴灰質體積減小.患者組中P3、N2潛伏期均與雙側殼覈、右側顳中迴體積呈正相關(均P ＜0.01);P3潛伏期與左側顳中迴、左側額中迴、左側梭狀迴體積呈正相關(均P＜0.01),而P3波幅與左側角迴、右側額上迴體積呈負相關(均P＜0.01);N2潛伏期與左側後釦帶迴、右側梭狀迴、枕葉、左側小腦體積呈正相關(均P＜0.01);患者組P300潛伏期和波幅與漢密爾頓抑鬱量錶的總分和各因子分無相關性.結論 首次髮病未服藥女性抑鬱癥患者存在特徵性腦灰質體積異常,其P300可能與多箇腦灰質區域相關,尤其與顳葉、基底神經節的關繫最明顯.
목적 탐토수차발병미복약녀성억욱증환자뇌회질체적변화특점,이급여인지사건상관전위P300적상관분석.방법 대25례18 ～58세수차발병미복약녀성억욱증환자(환자조)화28명건강대조자(대조조)행두부3D결구MRI소묘,병대환자조진행P300검사.결과 환자조교대조조우측액하회도개부、우측중앙전회회질체적감소.환자조중P3、N2잠복기균여쌍측각핵、우측섭중회체적정정상관(균P ＜0.01);P3잠복기여좌측섭중회、좌측액중회、좌측사상회체적정정상관(균P＜0.01),이P3파폭여좌측각회、우측액상회체적정부상관(균P＜0.01);N2잠복기여좌측후구대회、우측사상회、침협、좌측소뇌체적정정상관(균P＜0.01);환자조P300잠복기화파폭여한밀이돈억욱량표적총분화각인자분무상관성.결론 수차발병미복약녀성억욱증환자존재특정성뇌회질체적이상,기P300가능여다개뇌회질구역상관,우기여섭협、기저신경절적관계최명현.
Objective The present study aims to explore the grey matter volume changes in drugnaive first-episode major depressive disorder (MDD) female patients and to find out their correlation with event-related potential P3oo.Methods Twenty-five patients,aging between 18-58 years,diagnosed with first-episode MDD and 28 gender-,age-,education level-matched healthy controls were included in this study.All participants were assigned to receive 3D structural magnetic resonance imaging brain scans,and the patients were assigned to receive P30o tests.Results In contrast with healthy controls,decreased grey matter volume was detected in the right frontal operculum and the right precentral gyrus of patients,both P3 and N2 latencies were positively correlated with bilateral putamen nuclei (all P ＜ 0.01).The P3 latency was also positively associated with the volumes of left middle temporal gyrus,left middle frontal gyrus,and leftfusiform gyrus.The N2 latency was also positively associated with the volumes of left posterior cingulate gyrus,the right fusiform gyrus,the occipital lobe,and the left cerebellum (all P ＜ 0.01).The P3 amplitude was negatively associated with the volumes of left angular gyrus and right superior frontal gyrus (all P ＜0.01).No statistically significant correlation was found between each component of P300 and Hamilton Depression Scale scores (total and factor).Conclusions The abnormalities of grey matter volume are observed in certain brain regions in unmedicated female patients with first-episode MDD in this study.And the P300 in those patients are in correlation with many grey matter regions of the brain,especially temporal lobes and basal ganglia.
