中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
4期
217-220
,共4页
赵彬%王焕林%高志勤%余海鹰%过伟%汪广剑%毕银花%林芝%赵汉清
趙彬%王煥林%高誌勤%餘海鷹%過偉%汪廣劍%畢銀花%林芝%趙漢清
조빈%왕환림%고지근%여해응%과위%왕엄검%필은화%림지%조한청
精神分裂症%血管内皮生长因子A%成纤维细胞生长因子2
精神分裂癥%血管內皮生長因子A%成纖維細胞生長因子2
정신분렬증%혈관내피생장인자A%성섬유세포생장인자2
Schizophrenia%Vascular endothelial growth factor A%Fibroblast growth factor 2
目的 探讨未服药精神分裂症患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)、成纤维细胞生长因子2(fibroblast growth factor 2,FGF-2)的水平变化.方法 共纳入未服药精神分裂症患者54例(患者组),与患者组性别、年龄、体质量指数、受教育年限相匹配的健康对照54名(对照组),血清VEGF、FGF-2浓度用酶联免疫吸附法测定;用PANSS评定患者精神病理症状;采用独立样本t检验和Pearson相关分析对患者组和对照组血清VEGF、FGF-2水平的差异及影响因素进行分析.结果 (1)患者组血清VEGF[(713±101) ng/L]、FGF-2[(325±30) ng/L]的水平均较对照组[分别为(614±71)、(272±34) ng/L]高(t=5.84、8.57,均P＜0.01);(2)患者组不同性别、是否吸烟、是否有精神疾病家族史之间血清VEGF、FGF-2的水平差异均无统计学意义;(3)患者组血清VEGF、FGF-2的水平与年龄、总病程、体质量指数、PANSS阳性量表分、PANSS阴性量表分、PANSS一般精神病理量表分、PANSS总分均无相关性.结论 未服药精神分裂症患者血清VEGF、FGF-2的水平增高.
目的 探討未服藥精神分裂癥患者血清血管內皮生長因子(vascular endothelial growth factor,VEGF)、成纖維細胞生長因子2(fibroblast growth factor 2,FGF-2)的水平變化.方法 共納入未服藥精神分裂癥患者54例(患者組),與患者組性彆、年齡、體質量指數、受教育年限相匹配的健康對照54名(對照組),血清VEGF、FGF-2濃度用酶聯免疫吸附法測定;用PANSS評定患者精神病理癥狀;採用獨立樣本t檢驗和Pearson相關分析對患者組和對照組血清VEGF、FGF-2水平的差異及影響因素進行分析.結果 (1)患者組血清VEGF[(713±101) ng/L]、FGF-2[(325±30) ng/L]的水平均較對照組[分彆為(614±71)、(272±34) ng/L]高(t=5.84、8.57,均P＜0.01);(2)患者組不同性彆、是否吸煙、是否有精神疾病傢族史之間血清VEGF、FGF-2的水平差異均無統計學意義;(3)患者組血清VEGF、FGF-2的水平與年齡、總病程、體質量指數、PANSS暘性量錶分、PANSS陰性量錶分、PANSS一般精神病理量錶分、PANSS總分均無相關性.結論 未服藥精神分裂癥患者血清VEGF、FGF-2的水平增高.
목적 탐토미복약정신분렬증환자혈청혈관내피생장인자(vascular endothelial growth factor,VEGF)、성섬유세포생장인자2(fibroblast growth factor 2,FGF-2)적수평변화.방법 공납입미복약정신분렬증환자54례(환자조),여환자조성별、년령、체질량지수、수교육년한상필배적건강대조54명(대조조),혈청VEGF、FGF-2농도용매련면역흡부법측정;용PANSS평정환자정신병리증상;채용독립양본t검험화Pearson상관분석대환자조화대조조혈청VEGF、FGF-2수평적차이급영향인소진행분석.결과 (1)환자조혈청VEGF[(713±101) ng/L]、FGF-2[(325±30) ng/L]적수평균교대조조[분별위(614±71)、(272±34) ng/L]고(t=5.84、8.57,균P＜0.01);(2)환자조불동성별、시부흡연、시부유정신질병가족사지간혈청VEGF、FGF-2적수평차이균무통계학의의;(3)환자조혈청VEGF、FGF-2적수평여년령、총병정、체질량지수、PANSS양성량표분、PANSS음성량표분、PANSS일반정신병리량표분、PANSS총분균무상관성.결론 미복약정신분렬증환자혈청VEGF、FGF-2적수평증고.
Objective To investigate the possible role of vascular endothelial growth factor(VEGF) and fibroblast growth factor 2 (FGF-2) in the pathophysiology of schizophrenia.Methods Fifty-four drugnaive patients with schizophrenia and 54 sex-,age-,body mass index-,and education-matched healthy controls were consecutively involved in the study.The serum levels of VEGF and FGF-2 were detected with sandwich enzyme linked immunosorbent assay,and the Positive and Negative Symptoms Scale(PANSS) was used to evaluate psychopathological symptoms in patients.Two-sample t test and Pearson correlation test were used to analyze the serum levels of VEGF and FGF-2 in patients.Results (1) The serum levels of VEGF ((713 ± 101) ng/L) and FGF-2 ((325 ± 30) ng/L) in patients were significantly higher than that in the controls ((614 ± 71) ng/L and (272 ± 34) ng/L,t =5.84,8.57,both P ＜ 0.05).(2) In patients,there were no significant differences on the serum levels of VEGF and FGF-2 between man and women,ones with smoking and without smoking,ones with a family history of mental illness and without a family history.(3) The levels of serum VEGF and FGF-2 in patients were not correlated to age,the total course of illness,body mass index,the score of PANSS positive scale,score of PANSS negative scale,score of PANSS general psychopathology scale and PANSS total score.Conclusion It suggests that the serum levels of VEGF and FGF-2 increase in drug-naive patients with schizophrenia.
