中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2013年
4期
205-208
,共4页
邵幼林%张锁才%柳龙根%陈定贵%郭风彩
邵幼林%張鎖纔%柳龍根%陳定貴%郭風綵
소유림%장쇄재%류룡근%진정귀%곽풍채
脐带,胎血%肝炎病毒,乙型%血清标志物
臍帶,胎血%肝炎病毒,乙型%血清標誌物
제대,태혈%간염병독,을형%혈청표지물
Umbilical cord,fetal blood%Hepatitis B virus%Serum markers
目的 探讨脐带血与母亲血清乙型肝炎病毒(HBV)标志物的关系.方法 选择2009年8月至2010年1 1月在江苏省常州市第三人民医院住院分娩的340例HBsAg阳性母亲,定量检测分娩前母亲血清和分娩后脐带血HBV标志物.新生儿接受3剂乙型肝炎疫苗和2剂高效价乙型肝炎免疫球蛋白(HBIG),随访至12月龄.计量资料用中位数(M)表示,组间比较采用Kruskal-Wallis检验,相关性分析用Spearman秩相关.结果 340例HBsAg阳性母亲中HBeAg阳性175例,HBeAg阴性165例,共分娩新生儿341名.母亲血清HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc阳性率分别为100.00％,0,51.47％,38.82％和99.41％,脐带血分别为14.66％,0.59％,26.69％,39.88％和95.31％.脐带血HBsAg阳性组母亲血清HBsAg浓度明显高于脐带血HBsAg阴性组的母亲(419.40∶387.95,x2=4.592,P＜0.05),母亲血清HBeAg阳性组脐带血HBsAg浓度明显高于母亲血清HBeAg阴性组脐带血(0.04∶0.01,x2=5.674,P＜0.05).脐带血抗-HBe与抗-HBc水平分别与母亲血清中抗-HBe与抗-HBc的水平呈正相关(r=0.838和0.764,P值均＜0.01).随访婴儿至12月龄时,血清HBeAg阳性母亲所生婴儿的HBV感染率为11.29％(7/62),血清HBeAg阴性母亲所生婴儿无HBV感染.结论 母亲血清HBsAg浓度越高发生母婴传播的可能性越大,HBeAg阳性母亲的孩子感染HBV的风险高.
目的 探討臍帶血與母親血清乙型肝炎病毒(HBV)標誌物的關繫.方法 選擇2009年8月至2010年1 1月在江囌省常州市第三人民醫院住院分娩的340例HBsAg暘性母親,定量檢測分娩前母親血清和分娩後臍帶血HBV標誌物.新生兒接受3劑乙型肝炎疫苗和2劑高效價乙型肝炎免疫毬蛋白(HBIG),隨訪至12月齡.計量資料用中位數(M)錶示,組間比較採用Kruskal-Wallis檢驗,相關性分析用Spearman秩相關.結果 340例HBsAg暘性母親中HBeAg暘性175例,HBeAg陰性165例,共分娩新生兒341名.母親血清HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc暘性率分彆為100.00％,0,51.47％,38.82％和99.41％,臍帶血分彆為14.66％,0.59％,26.69％,39.88％和95.31％.臍帶血HBsAg暘性組母親血清HBsAg濃度明顯高于臍帶血HBsAg陰性組的母親(419.40∶387.95,x2=4.592,P＜0.05),母親血清HBeAg暘性組臍帶血HBsAg濃度明顯高于母親血清HBeAg陰性組臍帶血(0.04∶0.01,x2=5.674,P＜0.05).臍帶血抗-HBe與抗-HBc水平分彆與母親血清中抗-HBe與抗-HBc的水平呈正相關(r=0.838和0.764,P值均＜0.01).隨訪嬰兒至12月齡時,血清HBeAg暘性母親所生嬰兒的HBV感染率為11.29％(7/62),血清HBeAg陰性母親所生嬰兒無HBV感染.結論 母親血清HBsAg濃度越高髮生母嬰傳播的可能性越大,HBeAg暘性母親的孩子感染HBV的風險高.
목적 탐토제대혈여모친혈청을형간염병독(HBV)표지물적관계.방법 선택2009년8월지2010년1 1월재강소성상주시제삼인민의원주원분면적340례HBsAg양성모친,정량검측분면전모친혈청화분면후제대혈HBV표지물.신생인접수3제을형간염역묘화2제고효개을형간염면역구단백(HBIG),수방지12월령.계량자료용중위수(M)표시,조간비교채용Kruskal-Wallis검험,상관성분석용Spearman질상관.결과 340례HBsAg양성모친중HBeAg양성175례,HBeAg음성165례,공분면신생인341명.모친혈청HBsAg、항-HBs、HBeAg、항-HBe화항-HBc양성솔분별위100.00％,0,51.47％,38.82％화99.41％,제대혈분별위14.66％,0.59％,26.69％,39.88％화95.31％.제대혈HBsAg양성조모친혈청HBsAg농도명현고우제대혈HBsAg음성조적모친(419.40∶387.95,x2=4.592,P＜0.05),모친혈청HBeAg양성조제대혈HBsAg농도명현고우모친혈청HBeAg음성조제대혈(0.04∶0.01,x2=5.674,P＜0.05).제대혈항-HBe여항-HBc수평분별여모친혈청중항-HBe여항-HBc적수평정정상관(r=0.838화0.764,P치균＜0.01).수방영인지12월령시,혈청HBeAg양성모친소생영인적HBV감염솔위11.29％(7/62),혈청HBeAg음성모친소생영인무HBV감염.결론 모친혈청HBsAg농도월고발생모영전파적가능성월대,HBeAg양성모친적해자감염HBV적풍험고.
Objective To investigate the correlation of hepatitis B virus (HBV) markers between umbilical cord blood and maternal serum.Methods A total of 340 HBsAg positive mothers who delivered at the Third People' s Hospital of Changzhou during August 2009 and November 2010 were included in the study.HBV markers in the maternal serum before childbirth and umbilical cord blood after birth were quantitatively detected.The neonates received 3 doses of hepatitis B vaccine and 2 doses of hepatitis B immunoglobulin (HBIG),and followed up for 12 months.Measurement data were expressed as median (M),and Kruskal-Wallis test and Spearman correlation analysis were performed.Results There were 175HBeAg-positive and 165 HBeAg-negative mothers,and a total of 341 infants were delivered.The positive rates of HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc in maternal serum were 100.00％,0.0％,51.47％,38.82％ and 99.41％,respectively; while those in umbilical cord bloods were 14.66％,0.59％,26.69％,39.88％ and 95.31％,respectively.HBsAg concentration in maternal serum of HBsAg-positive umbilical cord blood group was higher than that of HBsAg-negative umbilical cord blood group (419.40∶ 387.95,x2 =4.592,P ＜ 0.05) ; while HBsAg concentration in umbilical cord blood of HBeAg-positive maternal serum was higher than that of the HBeAg-negative maternal serum group (0.04 ∶ 0.01,x2 =5.674,P ＜ 0.05).Anti-HBe and anti-HBc in umbilical cord blood were positively correlated with those in maternal serum (r =0.838,0.764,P ＜ 0.01).Seven out of 62 (11.29％) infants were infected with HBV in HBeAg-positive maternal serum group; while no infant infected in HBeAg-negative matemal serum group.Conclusion The higher maternal serum HBsAg concentration,the greater the risk of perinatal transmission,and infants born by HBeAg-positive mothers are of high risk of HBV infection.
