中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2013年
6期
335-338
,共4页
叶鸿雁%周方满%崔大伟%王海燕%涂林修%谢红意%葛婷婷
葉鴻雁%週方滿%崔大偉%王海燕%塗林脩%謝紅意%葛婷婷
협홍안%주방만%최대위%왕해연%도림수%사홍의%갈정정
腹泻,婴儿%疾病特征%轮状病毒属%腺病毒科%星状病毒属%札如病毒%诺如病毒
腹瀉,嬰兒%疾病特徵%輪狀病毒屬%腺病毒科%星狀病毒屬%札如病毒%諾如病毒
복사,영인%질병특정%륜상병독속%선병독과%성상병독속%찰여병독%낙여병독
Diarrhea,infantile%Disease attributes%Rotavirus%Adenoviridae%Mamastrovirus%Sapovirus%Norovirus
目的 了解浙江省宁波市北仑区婴幼儿急性腹泻的临床特征及其胃肠道病毒的感染情况.方法 选择2012年7月至2013年7月在北仑区人民医院儿科门诊的900例急性腹泻婴幼儿病例(≤5岁),分析婴幼儿急性腹泻的临床特征并采集粪便样本,用PCR方法检测A/B/C型轮状病毒(Rotavirus,RV)、肠道腺病毒(Enteric adenovirus,AdV)、星状病毒(Astrovirus,AstV)、札如病毒(Sapovirus,SV)及诺如病毒(Norovirus,NV),并采用x2检验对不同性别和年龄段患者病毒检出情况进行比较.结果 900份腹泻患儿粪便样本中369份呈阳性结果,其中单一病毒感染的291份,混合病毒感染78份.在单一病毒感染病例的样本中,NV检出率为19.4％(GⅠ型为4.9％,GⅡ型14.6％),RV-A为8.2％,未检出B型及C型RV,SV为2.9％,AstV为1.0％,AdV为0.8％.在混合感染病例的样本中,以RV-A与NV混合感染最多,为5.8％.2岁以下(含2岁)患儿的病毒总检出率(51.0％)显著高于＞2 ～5岁的患儿(22.1％,x2=70.404,P＜0.01).369例病毒检测阳性的患儿中,24.1％伴有发热,35.2％伴有呕吐症状.单一病毒感染病例发热、呕吐以及发热合并呕吐的发生率均低于混合感染病例(x2=17.878,21.869和14.155,P＜0.01).结论 NV和RV-A是浙江省宁波市北仑区婴幼儿急性腹泻的主要胃肠道病毒,2岁以下婴幼儿是这两种病毒的易感人群.
目的 瞭解浙江省寧波市北崙區嬰幼兒急性腹瀉的臨床特徵及其胃腸道病毒的感染情況.方法 選擇2012年7月至2013年7月在北崙區人民醫院兒科門診的900例急性腹瀉嬰幼兒病例(≤5歲),分析嬰幼兒急性腹瀉的臨床特徵併採集糞便樣本,用PCR方法檢測A/B/C型輪狀病毒(Rotavirus,RV)、腸道腺病毒(Enteric adenovirus,AdV)、星狀病毒(Astrovirus,AstV)、札如病毒(Sapovirus,SV)及諾如病毒(Norovirus,NV),併採用x2檢驗對不同性彆和年齡段患者病毒檢齣情況進行比較.結果 900份腹瀉患兒糞便樣本中369份呈暘性結果,其中單一病毒感染的291份,混閤病毒感染78份.在單一病毒感染病例的樣本中,NV檢齣率為19.4％(GⅠ型為4.9％,GⅡ型14.6％),RV-A為8.2％,未檢齣B型及C型RV,SV為2.9％,AstV為1.0％,AdV為0.8％.在混閤感染病例的樣本中,以RV-A與NV混閤感染最多,為5.8％.2歲以下(含2歲)患兒的病毒總檢齣率(51.0％)顯著高于＞2 ～5歲的患兒(22.1％,x2=70.404,P＜0.01).369例病毒檢測暘性的患兒中,24.1％伴有髮熱,35.2％伴有嘔吐癥狀.單一病毒感染病例髮熱、嘔吐以及髮熱閤併嘔吐的髮生率均低于混閤感染病例(x2=17.878,21.869和14.155,P＜0.01).結論 NV和RV-A是浙江省寧波市北崙區嬰幼兒急性腹瀉的主要胃腸道病毒,2歲以下嬰幼兒是這兩種病毒的易感人群.
목적 료해절강성저파시북륜구영유인급성복사적림상특정급기위장도병독적감염정황.방법 선택2012년7월지2013년7월재북륜구인민의원인과문진적900례급성복사영유인병례(≤5세),분석영유인급성복사적림상특정병채집분편양본,용PCR방법검측A/B/C형륜상병독(Rotavirus,RV)、장도선병독(Enteric adenovirus,AdV)、성상병독(Astrovirus,AstV)、찰여병독(Sapovirus,SV)급낙여병독(Norovirus,NV),병채용x2검험대불동성별화년령단환자병독검출정황진행비교.결과 900빈복사환인분편양본중369빈정양성결과,기중단일병독감염적291빈,혼합병독감염78빈.재단일병독감염병례적양본중,NV검출솔위19.4％(GⅠ형위4.9％,GⅡ형14.6％),RV-A위8.2％,미검출B형급C형RV,SV위2.9％,AstV위1.0％,AdV위0.8％.재혼합감염병례적양본중,이RV-A여NV혼합감염최다,위5.8％.2세이하(함2세)환인적병독총검출솔(51.0％)현저고우＞2 ～5세적환인(22.1％,x2=70.404,P＜0.01).369례병독검측양성적환인중,24.1％반유발열,35.2％반유구토증상.단일병독감염병례발열、구토이급발열합병구토적발생솔균저우혼합감염병례(x2=17.878,21.869화14.155,P＜0.01).결론 NV화RV-A시절강성저파시북륜구영유인급성복사적주요위장도병독,2세이하영유인시저량충병독적역감인군.
Objective To analyze the distribution and clinical characteristics of gastrointestinal virus infection in infants with acute diarrhea.Methods Stool samples and clinical data were collected from 900 infants (≤5 years old) with acute diarrhea in outpatient department of Beilun District People' s Hospital during July 2012 and July 2013.Specimens were tested for 5 gastrointestinal virus including group A/B/C rotavirus (RV),adenovirus (AdV),astrovirus (AstV),sapovirus (SV) and norovirus (NV) by the multiplex PCR assay.Chi-square test was performed to compare the positive rates of virus infection among children with different genders and ages.Results Among 900 stool samples,369 were positive of gastrointestinal virus,of which 291 were positive for single virus and 78 for mixed virus.In single virus infection,NV was detected with the highest positive rate of 19.4％ (4.9％ for G Ⅰ and 14.6％ for G Ⅱ),followed by RV-A (8.2％),SV (2.9％),AstV (1.0％) and AdV (0.8％).RV-B and C type were not found.In 78 cases with mixed infections,RV-A plus NV infection was the most common one with a prevalent rate of 5.8％.The positive rate in age group ≤2 years old was 51.0％,which was significantly higher than that of age group ＞ 2-5 years old (22.1％,x2 =70.404,P ＜ 0.01).In 369 children with positive gastrointestinal virus,fever was present in 24.1％,and vomit in 35.2％ of children.Fever,vomit and fever plus vomit was more common symptoms in children with mixed infections (x2 =17.878,21.869 and 14.155,P ＜ 0.01).Conclusion NV and RV-A are the most common pathogens in infants with acute diarrhea in Beilun district,especially in children younger than 2 years old.
