中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
11期
859-862
,共4页
闫绍妹%翟庆峰%邢杰%李万伟%高祥春%邱玉刚
閆紹妹%翟慶峰%邢傑%李萬偉%高祥春%邱玉剛
염소매%적경봉%형걸%리만위%고상춘%구옥강
农药%妊娠结局%Meta分析
農藥%妊娠結跼%Meta分析
농약%임신결국%Meta분석
Pesticide%Pregnancy outcomes%Meta-analysis
目的 对农民在农业种植过程中农药暴露与不良妊娠结局的关系进行分析.方法 收集1990至2012年2月国内外发表的有关农药暴露与妊娠结局关系的文献,应用revman 4.2软件对符合纳入标准的文献进行Meta分析.结果 共有12篇文献纳入研究,与对照组相比,农药暴露农民自然流产的合并OR为1.52(95％CI∶1.04,2.21,P=0.03)；早产的合并OR为1.33 (95％CI∶1.09,1.61,P=0.005)；死胎的合并OR为1.22(95％CI∶1.16,1.29,P＜0.01),农药暴露可使自然流产、早产、死胎的危险性增加.死产的合并OR为1.90(95％CI∶0.58,6.28,P=0.29)；畸形的合并OR为2.02(95％CI∶0.84,4.69,P=0.12)；低出生体重的合并OR为1.62(95％CI∶0.60,4.39,P=0.34)；新生儿死亡的合并OR为2.18 (95％CI∶0.54,8.88,P=0.28)；生育延迟的合并OR为1.43(95％CI∶0.93,2.18,P=0.1),故尚不能认为农药暴露与死产、畸形、低出生体重、新生儿死亡、生育延迟有相关性.结论 农药暴露可以导致农民的不良妊娠结局,使自然流产、早产、死胎的危险性增加.
目的 對農民在農業種植過程中農藥暴露與不良妊娠結跼的關繫進行分析.方法 收集1990至2012年2月國內外髮錶的有關農藥暴露與妊娠結跼關繫的文獻,應用revman 4.2軟件對符閤納入標準的文獻進行Meta分析.結果 共有12篇文獻納入研究,與對照組相比,農藥暴露農民自然流產的閤併OR為1.52(95％CI∶1.04,2.21,P=0.03)；早產的閤併OR為1.33 (95％CI∶1.09,1.61,P=0.005)；死胎的閤併OR為1.22(95％CI∶1.16,1.29,P＜0.01),農藥暴露可使自然流產、早產、死胎的危險性增加.死產的閤併OR為1.90(95％CI∶0.58,6.28,P=0.29)；畸形的閤併OR為2.02(95％CI∶0.84,4.69,P=0.12)；低齣生體重的閤併OR為1.62(95％CI∶0.60,4.39,P=0.34)；新生兒死亡的閤併OR為2.18 (95％CI∶0.54,8.88,P=0.28)；生育延遲的閤併OR為1.43(95％CI∶0.93,2.18,P=0.1),故尚不能認為農藥暴露與死產、畸形、低齣生體重、新生兒死亡、生育延遲有相關性.結論 農藥暴露可以導緻農民的不良妊娠結跼,使自然流產、早產、死胎的危險性增加.
목적 대농민재농업충식과정중농약폭로여불량임신결국적관계진행분석.방법 수집1990지2012년2월국내외발표적유관농약폭로여임신결국관계적문헌,응용revman 4.2연건대부합납입표준적문헌진행Meta분석.결과 공유12편문헌납입연구,여대조조상비,농약폭로농민자연유산적합병OR위1.52(95％CI∶1.04,2.21,P=0.03)；조산적합병OR위1.33 (95％CI∶1.09,1.61,P=0.005)；사태적합병OR위1.22(95％CI∶1.16,1.29,P＜0.01),농약폭로가사자연유산、조산、사태적위험성증가.사산적합병OR위1.90(95％CI∶0.58,6.28,P=0.29)；기형적합병OR위2.02(95％CI∶0.84,4.69,P=0.12)；저출생체중적합병OR위1.62(95％CI∶0.60,4.39,P=0.34)；신생인사망적합병OR위2.18 (95％CI∶0.54,8.88,P=0.28)；생육연지적합병OR위1.43(95％CI∶0.93,2.18,P=0.1),고상불능인위농약폭로여사산、기형、저출생체중、신생인사망、생육연지유상관성.결론 농약폭로가이도치농민적불량임신결국,사자연유산、조산、사태적위험성증가.
Objective To analyze the relationship between pesticide exposure and adverse pregnancy outcomes in famers.Methods A search was conducted to collect the articles about the relationship between pesticide exposure and adverse pregnancy outcomes published worldwide from 1990 to February 2012.Metaanalysis was performed on the collected articles using RevMan 4.2 software.Results Twelve articles were collected.Compared with the controls,the pesticide-exposed famers showed a combined odds ratio (OR) for spontaneous abortion of 1.52 (95％CI∶1.04～2.21; P=0.03),a combined OR for premature birth of 1.33 (95％CI∶1.09～1.61; P=0.005),a combined OR for dead fetus of 1.22 (95％CI∶1.16～1.29; P＜0.01),a combined OR for stillbirth of 1.90 (95％CI∶0.58～6.28; P=0.29),a combined OR for birth defect of 2.02 (95％CI∶0.84-4.69; P=0.12),a combined OR for low birth weight of 1.62 (95％CI∶0.60～4.39; P=0.34),a combined OR for neonatal death of 2.18 (95％CI∶0.54～8.88; P=0.28),and a combined OR for delayed conception of 1.43 (95％CI:0.93～2.18; P=0.1).Pesticide exposure increased the risks for spontaneous abortion,premature birth,and dead fetus,but was not significantly associated with stillbirth,birth defect,low birth weight,neonatal death,and delayed conception.Conclusion Pesticide exposure can cause adverse pregnancy outcomes in farmers,increasing the risks of spontaneous abortion,premature birth,and dead fetus.
