CAJ | 학술논문

目的研究焦炉作业工人尿中多环芳烃(polycyclic aromatic hydrocarbons,PAHs)代谢物与肺功能下降的关系,为进一步阐明焦炉工人早期肺部损伤机制以及制订预防职业性肺损伤的策略提供科学依据.方法检测环境中一氧化碳、二氧化硫、苯可溶物、颗粒物及颗粒物上载带PAHs的浓度,采用问卷调查和健康体检的方式收集武汉某焦化厂912名工人的职业信息和健康状况,按照外环境检测结果和职业史分为办公室人群(对照组)和焦炉作业工人(暴露组).收集工人的清晨尿液,用气相色谱-质谱联用仪检测尿中10种PAHs代谢物,并采用肺功能分析仪检测工人的肺功能.结果暴露组的[FEV1.0 (91.12％±13.31％)、FEV1.0/FVC(108.61％±20.37％)]均明显低于对照组[(94.16％±15.57％)和(113.45％±19.70％)],暴露组工人的尿PAHs代谢物中羟基菲和1-羟基芘的蓄积作用分别与FEV1.0/FVC呈负相关(β=-0.136,β=-0.100),P值均小于0.05.结论焦炉作业工人尿中PAHs代谢物与肺功能下降相关联,提示长期暴露于职业性PAHs引起工人肺部早期损伤,并且PAHs中的菲和芘有可能是引起焦炉工肺部早期损伤的主要物质.
목적 연구초로작업공인뇨중다배방경(polycyclic aromatic hydrocarbons,PAHs)대사물여폐공능하강적관계,위진일보천명초로공인조기폐부손상궤제이급제정예방직업성폐손상적책략제공과학의거.방법 검측배경중일양화탄、이양화류、분가용물、과립물급과립물상재대PAHs적농도,채용문권조사화건강체검적방식수집무한모초화엄912명공인적직업신식화건강상황,안조외배경검측결과화직업사분위판공실인군(대조조)화초로작업공인(폭로조).수집공인적청신뇨액,용기상색보-질보련용의검측뇨중10충PAHs대사물,병채용폐공능분석의검측공인적폐공능.결과 폭로조적[FEV1.0 (91.12％±13.31％)、FEV1.0/FVC(108.61％±20.37％)]균명현저우대조조[(94.16％±15.57％)화(113.45％±19.70％)],폭로조공인적뇨PAHs대사물중간기비화1-간기비적축적작용분별여FEV1.0/FVC정부상관(β=-0.136,β=-0.100),P치균소우0.05.결론 초로작업공인뇨중PAHs대사물여폐공능하강상관련,제시장기폭로우직업성PAHs인기공인폐부조기손상,병차PAHs중적비화비유가능시인기초로공폐부조기손상적주요물질.
Objective To analyze the relationship between metabolites of polycyclic aromatic hydrocarbons (PAHs) and lung function in coke oven workers,and to provide scientific basis for further exploring the potential mechanism and developing the preventing strategies of the workers' early lung damage.Methods We measured carbon monoxide,sulfur dioxide,benzene soluble matter,particulate matters,and PAHs at different workplaces of a coke oven plant.Detailed information on demography and occupational health condition of 912 workers were collected.We divided these workers into control group and coke oven group according to their workplaces and the different concentrations of COEs in the environment.We detected 10 urinary PAH metabolites and lung function using gas chromatography-mass spectrometry and spirometric tests,respectively.Results FEV1.0 (91.12±13.31) and FEV1.0/FVC (108.61±20.37) of the coke oven group is significantly lower than the control group (94.16 ±15.57,113.45 ±19.70).In the coke oven group,the hydroxyphenanthrene and 1-hydroxypyrene are negatively correlated with FEV1.0/FVC (β=-0.136,β=-0.100),Ptrend＜0.05 for all.Conclusion The dose response decrease of lung function is associated with the urinary PAH metabolites in coke oven workers.Indicated that the long exposure to PAHs may cause the early lung damage in coke oven workers,phenanthrene and pyrene may be the main factors.