中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2013年
9期
700-702
,共3页
刘培跃%孙永习%谷德权%程建良
劉培躍%孫永習%穀德權%程建良
류배약%손영습%곡덕권%정건량
尘肺%肺疾病,阻塞性%亚胺培南%革兰阴性菌感染
塵肺%肺疾病,阻塞性%亞胺培南%革蘭陰性菌感染
진폐%폐질병,조새성%아알배남%혁란음성균감염
Pneumoconiosis%Lung diseases,obstructive%Imipenem%Gram-negative bacterial infections
目的 分析煤工尘肺(CWP)慢性阻塞性肺疾病(COPD)下呼吸道感染耐亚胺培南革兰阴性杆菌(IR-GNB)的耐药特性,为临床治疗提供依据.方法 对从煤工尘肺并发COPD下呼吸道感染患者痰液中分离的66株IR-GNB研究分布特征,采用K-B纸片扩散法研究菌株的耐药特性.结果 66株IR-GNB主要以铜绿假单胞菌(29株,占43.9％);鲍曼不动杆菌(17株,占25.8％);嗜麦芽寡养单胞菌(11株,占16,7％)等细菌为主.所有细菌的耐药性均较强,其中铜绿假单胞菌对环丙沙星、多黏菌素B、磷霉素、阿米卡星敏感率大于50％;鲍曼不动杆菌对磷霉素、多黏菌素B、头孢哌酮/舒巴坦敏感率大于55％;嗜麦芽寡养单胞菌对复方新诺明、环丙沙星、哌拉西林/他唑巴坦、左氧氟沙星、多黏菌素B、头孢哌酮/舒巴坦敏感率超过50％.结论 煤工尘肺COPD下呼吸道IR-GNB以铜绿假单胞菌、鲍曼不动杆菌、嗜麦芽寡养单胞菌等非发酵细菌为主,细菌耐药性较强,仅对少数药物敏感.
目的 分析煤工塵肺(CWP)慢性阻塞性肺疾病(COPD)下呼吸道感染耐亞胺培南革蘭陰性桿菌(IR-GNB)的耐藥特性,為臨床治療提供依據.方法 對從煤工塵肺併髮COPD下呼吸道感染患者痰液中分離的66株IR-GNB研究分佈特徵,採用K-B紙片擴散法研究菌株的耐藥特性.結果 66株IR-GNB主要以銅綠假單胞菌(29株,佔43.9％);鮑曼不動桿菌(17株,佔25.8％);嗜麥芽寡養單胞菌(11株,佔16,7％)等細菌為主.所有細菌的耐藥性均較彊,其中銅綠假單胞菌對環丙沙星、多黏菌素B、燐黴素、阿米卡星敏感率大于50％;鮑曼不動桿菌對燐黴素、多黏菌素B、頭孢哌酮/舒巴坦敏感率大于55％;嗜麥芽寡養單胞菌對複方新諾明、環丙沙星、哌拉西林/他唑巴坦、左氧氟沙星、多黏菌素B、頭孢哌酮/舒巴坦敏感率超過50％.結論 煤工塵肺COPD下呼吸道IR-GNB以銅綠假單胞菌、鮑曼不動桿菌、嗜麥芽寡養單胞菌等非髮酵細菌為主,細菌耐藥性較彊,僅對少數藥物敏感.
목적 분석매공진폐(CWP)만성조새성폐질병(COPD)하호흡도감염내아알배남혁란음성간균(IR-GNB)적내약특성,위림상치료제공의거.방법 대종매공진폐병발COPD하호흡도감염환자담액중분리적66주IR-GNB연구분포특정,채용K-B지편확산법연구균주적내약특성.결과 66주IR-GNB주요이동록가단포균(29주,점43.9％);포만불동간균(17주,점25.8％);기맥아과양단포균(11주,점16,7％)등세균위주.소유세균적내약성균교강,기중동록가단포균대배병사성、다점균소B、린매소、아미잡성민감솔대우50％;포만불동간균대린매소、다점균소B、두포고동/서파탄민감솔대우55％;기맥아과양단포균대복방신낙명、배병사성、고랍서림/타서파탄、좌양불사성、다점균소B、두포고동/서파탄민감솔초과50％.결론 매공진폐COPD하호흡도IR-GNB이동록가단포균、포만불동간균、기맥아과양단포균등비발효세균위주,세균내약성교강,부대소수약물민감.
Objective To investigate the drug resistance ofimipenem-resistant (IR) Gram-negative bacilli (GNB) in coal workers' pneumoconiosis (CWP)-chronic obstructive pulmonary disease (COPD) patients with lower respiratory tract infection (LRTI) and to provide a basis for clinical treatment.Methods Sixty-six strains of IR-GNB were isolated from the sputum of CWP-COPD patients with LRTI,and the bacterial spectrum was investigated.The drug resistance of bacterial strains was studied by KB disk diffusion method.Results Among the 66 strains of IR-GNB,29 (43.9％) were Pseudomonas aeruginosa,17 (25.8％) were Acinetobacter baumannii,and 11 (16.7％) were Stenotrophomonas maltophilia.The drug sensitivity test showed that all bacteria had high drug resistance; Pseudomonas aeruginosa had a susceptibility rate higher than 50％ to ciprofloxacin,polymyxin B,fosfomycin,and amikacin,Acinetobacter baumannii had a susceptibility rate higher than 55％ to fosfomycin,polymyxin B,and cefoperazone/sulbactam,Stenotrophomonas mahophilia had a susceptibility rate higher than 50％ to cotrimoxazole,ciprofloxacin,piperacillin/tazobactam,levofloxacin,polymyxin B,and cefoperazone/sulbactam,and Pseudomonas cepacia had a susceptibility rate higher than 50％ to piperacillin/tazobactam,ciprofloxacin,cefoperazone/sulbactam,and polymyxin B.Conclusion The main species of IR-GNB are such non-fermentative bacteria as Pseudomonas aeruginosa,Acinetobacter baumannii,and Stenotrophomonas maltophilia in CWP-COPD patients with LRTI.These bacteria have high drug resistance and are sensitivc to only a limited range of antibiotics.
