CAJ | 학술논문

目的分析职业性急性二甲基甲酰胺(DMF)中毒的临床特点及诊断要点,探讨急性DMF中毒机制.方法对16例职业性急性DMF中毒病例临床资料包括症状、体征、相关检查结果进行综合分析.结果职业性急性DMF中毒的临床特点以消化系统损害为主要表现,其中腹痛较为突出,胃镜检查未发现有出血性胃肠炎改变,腹痛程度与谷丙转氨酶(ALT)之间无明显的相关性(rs=0.109,P＞0.05).结论建议诊断标准中将腹痛作为中毒诊断及分级的参考指标之一.DMF中毒机制目前尚不明确,多认为与DMF代谢的中间产物异氰酸甲酯有关.
목적 분석직업성급성이갑기갑선알(DMF)중독적림상특점급진단요점,탐토급성DMF중독궤제.방법 대16례직업성급성DMF중독병례림상자료포괄증상、체정、상관검사결과진행종합분석.결과 직업성급성DMF중독적림상특점이소화계통손해위주요표현,기중복통교위돌출,위경검사미발현유출혈성위장염개변,복통정도여곡병전안매(ALT)지간무명현적상관성(rs=0.109,P＞0.05).결론 건의진단표준중장복통작위중독진단급분급적삼고지표지일.DMF중독궤제목전상불명학,다인위여DMF대사적중간산물이청산갑지유관.
Objective To analyze the clinical features and diagnostic points of occupational acute dimethylformamide (DMF) poisoning and to explore the mechanism of occupational acute DMF poisoning.Methods A comprehensive analysis was performed on the clinical data of 16 cases of occupational acute DMF poisoning,including symptoms,signs,and laboratory testing results.Results The main clinical features of occupational acute DMF poisoning were digestive system impairments,especially abdominalgia.Hemorrhagic gastroenteritis was not found by gastroscopy.There was no significant correlation between the degree of abdominalgia and alanine aminotransferase level (rs=0.109,P＞0.05).Conclusion Abdominalgia is recommended to be one of the reference indices for the diagnosis and degrading of occupational acute DMF poisoning,The mechanism of DMF poisoning remains unclear,but it is considered to be related to methyl isocyanate,the intermediate product of DMF metabolism.