CAJ | 학술논문

目的研制工作场所空气中二甲氧基甲烷的职业接触限值.方法收集二甲氧基甲烷的理化性质、毒理学资料、职业流行病学研究资料,在分析以上资料的基础上,按照工作场所有害因素职业接触限值研制的原则及方法,制订工作场所空气中二甲氧基甲烷的职业接触限值.结果二甲氧基甲烷生产企业采集165份空气样品,其中14份样品二甲氧基甲烷浓度超过3000 mg/m3,占全部样品8.48％；当暴露浓度大于6000 mg/m3时,暴露员工的不适症状发生率与对照组相比明显增加(P＜0.01)；各暴露组与对照组间的健康检查异常结果构成比差异无统计学意义(P＞0.05).结论建议将我国工作场所空气中二甲氧基甲烷的时间加权容许浓度(PC-TWA)定为3100 mg/m3.该标准的安全性符合毒理学和职业流行病学的相关要求,同时较好地契合了我国现有的经济技术水平,在国内有较好的适用性.
목적 연제공작장소공기중이갑양기갑완적직업접촉한치.방법 수집이갑양기갑완적이화성질、독이학자료、직업류행병학연구자료,재분석이상자료적기출상,안조공작장소유해인소직업접촉한치연제적원칙급방법,제정공작장소공기중이갑양기갑완적직업접촉한치.결과 이갑양기갑완생산기업채집165빈공기양품,기중14빈양품이갑양기갑완농도초과3000 mg/m3,점전부양품8.48％；당폭로농도대우6000 mg/m3시,폭로원공적불괄증상발생솔여대조조상비명현증가(P＜0.01)；각폭로조여대조조간적건강검사이상결과구성비차이무통계학의의(P＞0.05).결론 건의장아국공작장소공기중이갑양기갑완적시간가권용허농도(PC-TWA)정위3100 mg/m3.해표준적안전성부합독이학화직업류행병학적상관요구,동시교호지계합료아국현유적경제기술수평,재국내유교호적괄용성.
Objective To study the occupational exposure limit of dimethoxymethane (DMM) in workplace air.Methods Literature research was conducted on DMM; information on its physicochemical properties,toxicology,and occupational epidemiology was collected.Upon analyzing these data,an occupational exposure limit of DMM in workplace air was proposed according to the guidelines and principles of developing occupational exposure limits for harmful factors in workplaces.Results A total of 165 air samples were collected from DMM manufacturers,14 of which had a DMM concentration over 3000 mg/m3,accounting for 8.48％ of all samples.Compared with the control group,the exposed employees had a significantly increased incidence of discomfort symptoms when exposed to more than 6000 mg/m3 DMN (P＜0.01).No significant differences in the constituent ratios of abnormal results in physical examinations were found between the exposure groups and control group (P＞0.05).Conclusion We recommend to set the permissible concentration-time weighed average to 3100 mg/m3 as the occupational exposure limit of DMM in workplace air in China.This occupational exposure limit standard meets the relevant requirements of toxicology and occupational epidemiology,as well as fits well with our country' s current economical and technological levels.This standard has high applicability in China's domestic settings.