CAJ | 학술논문

目的探讨DNA甲基转移酶1基因(DNMT1) rs12984523、rs16999593和rs2228612单核苷酸多态性与中国汉族人群中噪声性听力损失(NIHL)易感性之间的关联.方法采用病例-对照研究,电测听双耳高频平均听阈值≥40 dB为病例组,共188名工人；电测听结果双耳高频平均听阈值＜40dB的300名工人为对照组.应用TaqMan探针法检测3个SNP位点的基因型.结果 DNMT1rs2228612携带TT基因型为NIHL的危险因素(调整后OR=1.69,95％CI:1.14～2.52).结论在188例电测听双耳高频平均听阈值≥40 dB的中国汉族人群中,DNMT1 rs 2228612与噪声性听力损失的易感性有关.
목적 탐토DNA갑기전이매1기인(DNMT1) rs12984523、rs16999593화rs2228612단핵감산다태성여중국한족인군중조성성은력손실(NIHL)역감성지간적관련.방법 채용병례-대조연구,전측은쌍이고빈평균은역치≥40 dB위병례조,공188명공인；전측은결과쌍이고빈평균은역치＜40dB적300명공인위대조조.응용TaqMan탐침법검측3개SNP위점적기인형.결과 DNMT1rs2228612휴대TT기인형위NIHL적위험인소(조정후OR=1.69,95％CI:1.14～2.52).결론 재188례전측은쌍이고빈평균은역치≥40 dB적중국한족인군중,DNMT1 rs 2228612여조성성은력손실적역감성유관.
Objective To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523,rs16999593,and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.Methods This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position,who were matched for age and gender.The cases had a binaural average high-frequency hearing threshold not less than 40 dB,and the controls had a binaural average high-frequency heating threshold less than 40 dB.The genotypes at the three SNPs were determined by TaqMan probe.Results TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR=1.69,95％ CI:1.14-2.52).Conclusion The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.