CAJ | 학술논문

目的了解谷胱甘肽硫转移酶M1(GSTM1)和T1(GSTT1)基因多态性与噪声相关性听力损失的关系.方法检索Cochrane图书馆、PubMed、OVID、EMBASE、Springer、万方数据库、维普数据库、中国期刊全文数据库及中国生物医学文献数据库,收集GSTM1或GSTT1与噪声相关性听力损失的病例对照研究.按照纳入标准选择文献,提取数据,应用Revman5.0软件进行统计学处理.结果共纳入中外文献5篇,Meta分析及亚组分析显示,GSTM1缺失型较野生型患噪声相关性听力损失风险增高(缺失型/野生型,OR=1.37,95％CI:1.13～1.66),中国人群GSTM1基因缺失型患噪声相关性听力损失风险增高(OR=1.5,95％CI:1.2～1.86)；GSTT1缺失型较野生型发生噪声导致的听力损失风险无明显增高.结论 GSTM1基因多态性与噪声相关性听力损失有关,GSTT1基因多态性与噪声相关性听力损失无关.
목적 료해곡광감태류전이매M1(GSTM1)화T1(GSTT1)기인다태성여조성상관성은력손실적관계.방법 검색Cochrane도서관、PubMed、OVID、EMBASE、Springer、만방수거고、유보수거고、중국기간전문수거고급중국생물의학문헌수거고,수집GSTM1혹GSTT1여조성상관성은력손실적병례대조연구.안조납입표준선택문헌,제취수거,응용Revman5.0연건진행통계학처리.결과 공납입중외문헌5편,Meta분석급아조분석현시,GSTM1결실형교야생형환조성상관성은력손실풍험증고(결실형/야생형,OR=1.37,95％CI:1.13～1.66),중국인군GSTM1기인결실형환조성상관성은력손실풍험증고(OR=1.5,95％CI:1.2～1.86)；GSTT1결실형교야생형발생조성도치적은력손실풍험무명현증고.결론 GSTM1기인다태성여조성상관성은력손실유관,GSTT1기인다태성여조성상관성은력손실무관.
Objective To evaluate the association of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms with noise-induced hearing loss.Methods The Cochrane library,PubMed,OVID,EMBASE,Springer,Wanfang Data,VIP,CNKI,and CBM were searched to collect case-control studies on GSTM1 or GSTT1 polymorphism and noise-induced hearing loss.The articles meeting the inclusion criteria were reviewed systematically,and the reported data were aggregated using Revman 5.0.Results Five studies were included in the meta-analysis.The meta-analysis and subgroup analysis showed that the persons with GSTM 1 null genotype had an increased risk of noise-induced hearing loss compared with those with GSTM1 wild genotype (OR=1.37,95％C1:1.13～1.66); in the Chinese population,the risk of noise-induced hearing loss was higher in persons with GSTM1 null genotype than in those with GSTM1 wild genotype (OR=1.5,95％C1:1.2～1.86); there was no significant difference in the risk of noise-induced hearing loss between persons with GSTT1 null and wild genotypes.Conclusion GSTM1 polymorphism is related to noise-induced hearing loss,but GSTT1 polymorphism is unrelated to this condition.