CAJ | 학술논문

目的研究蓝莓果皮主要活性成分花青素对镉致小鼠睾丸损伤的保护作用.方法对小鼠注射一定浓度的镉建立小鼠睾丸损伤模型,对睾丸损伤小鼠分别灌饲不同浓度的花青素,通过测定小鼠睾丸中丙二醛(MDA)含量和蛋白羰基化(PCO)水平,以及过氧化氢酶(CAT)和超氧化物歧化酶(SOD)的变化,探讨镉对睾丸的损伤作用及花青素的保护效果.结果镉染毒组小鼠睾丸中MDA含量和PCO水平较对照组明显升高(P＜0.05),SOD和CAT的活力较对照组明显降低(P＜0.01),而花青素能够减少MDA和PCO的增加;缓解SOD和CAT的活力的变化.结论花青素通过抑制镉所诱导的氧化压力,起到保护作用,花青素的抗氧化作用可能与其特殊的化学结构有关.
목적 연구람매과피주요활성성분화청소대력치소서고환손상적보호작용.방법 대소서주사일정농도적력건립소서고환손상모형,대고환손상소서분별관사불동농도적화청소,통과측정소서고환중병이철(MDA)함량화단백탄기화(PCO)수평,이급과양화경매(CAT)화초양화물기화매(SOD)적변화,탐토력대고환적손상작용급화청소적보호효과.결과 력염독조소서고환중MDA함량화PCO수평교대조조명현승고(P＜0.05),SOD화CAT적활력교대조조명현강저(P＜0.01),이화청소능구감소MDA화PCO적증가;완해SOD화CAT적활력적변화.결론 화청소통과억제력소유도적양화압력,기도보호작용,화청소적항양화작용가능여기특수적화학결구유관.
Objective To study the effect of Anthocyanin (Ay) on Cadmium-Induced Mouse testis Damage.Methods Mouse testis damage model were constructed and testis malonaldehyde (MDA) and protein carbonxyl content (PCO),as well as catalase (CAT) and superoxide dismutase (SOD) were determined.Results The intoxication of cadmium can cause the increase of MDA and PCO content in mouse testis (P＜0.05),however,the activities of SOD and CAT were altered (P＜0.01).Conclusion Ay have the strong potent to scavenge free radicals,owing to its special chemical structures,and act as a protector to inhibit the oxidative stress induced by cadmium.