中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
11期
1006-1009
,共4页
张燕京%尚雅静%赵班%毛永辉
張燕京%尚雅靜%趙班%毛永輝
장연경%상아정%조반%모영휘
肾小管%肾功能试验%肾小球滤过率%β2微球蛋白
腎小管%腎功能試驗%腎小毬濾過率%β2微毬蛋白
신소관%신공능시험%신소구려과솔%β2미구단백
Kidney tubules%Kidney function tests%Glomerular filtration rate%Beta 2-microglobulin
目的 总结我院干部门诊老年男性患者肾小管功能增龄性变化,并进行相关危险因素分析. 方法 研究对象共229例,分为＜80岁组和≥80岁组,排除诊断为慢性肾脏病的患者.测定尿常规、血肌酐、血尿素、尿β2微球蛋白(β2-MG)、尿α1微球蛋白(α1-MG)；根据Cockcroft-Gault公式计算估测肾小球滤过率(eGFR).总结年龄与上述指标的相关关系,并对相关危险因素进行多因素Logistic回归分析. 结果 229例患者平均年龄(76±10)岁,其中＜80岁组142例,≥80岁组87例.与＜80岁组比较,≥80岁组eGFR水平明显降低,分别为(80.3±18.0)ml/min比(55.0±12.7)ml/min(t=9.882,P＜0.01)；尿比重明显降低(1.016±0.006比1.013±0.006)；尿pH值(6.2±0.8比6.6±0.8)、尿β2-MG[(0.96±1.02)mg/L比(2.08±3.56) mg/L]和尿α1-MG[(6.67±3.57)mg/L比(8.71±6.59)mg/L]则明显升高,差异均有统计学意义.相关分析结果显示,eGFR和尿比重与患者年龄分别呈明显负相关(r=0.692和r=-0.280,P＜0.01),与尿pH值(r=0.255)、尿32-MG(r=0.262)和尿α1 MG(r=0.228)呈明显正相关(均P＜0.01).多因素Logistic回归分析显示冠心病为肾小管功能进展的独立危险因素(OR=4.251,P=0.002). 结论 高龄老年男性患者肾小管功能随着年龄的增长而明显减退,冠心病是肾小管功能进展的独立危险因素.
目的 總結我院榦部門診老年男性患者腎小管功能增齡性變化,併進行相關危險因素分析. 方法 研究對象共229例,分為＜80歲組和≥80歲組,排除診斷為慢性腎髒病的患者.測定尿常規、血肌酐、血尿素、尿β2微毬蛋白(β2-MG)、尿α1微毬蛋白(α1-MG)；根據Cockcroft-Gault公式計算估測腎小毬濾過率(eGFR).總結年齡與上述指標的相關關繫,併對相關危險因素進行多因素Logistic迴歸分析. 結果 229例患者平均年齡(76±10)歲,其中＜80歲組142例,≥80歲組87例.與＜80歲組比較,≥80歲組eGFR水平明顯降低,分彆為(80.3±18.0)ml/min比(55.0±12.7)ml/min(t=9.882,P＜0.01)；尿比重明顯降低(1.016±0.006比1.013±0.006)；尿pH值(6.2±0.8比6.6±0.8)、尿β2-MG[(0.96±1.02)mg/L比(2.08±3.56) mg/L]和尿α1-MG[(6.67±3.57)mg/L比(8.71±6.59)mg/L]則明顯升高,差異均有統計學意義.相關分析結果顯示,eGFR和尿比重與患者年齡分彆呈明顯負相關(r=0.692和r=-0.280,P＜0.01),與尿pH值(r=0.255)、尿32-MG(r=0.262)和尿α1 MG(r=0.228)呈明顯正相關(均P＜0.01).多因素Logistic迴歸分析顯示冠心病為腎小管功能進展的獨立危險因素(OR=4.251,P=0.002). 結論 高齡老年男性患者腎小管功能隨著年齡的增長而明顯減退,冠心病是腎小管功能進展的獨立危險因素.
목적 총결아원간부문진노년남성환자신소관공능증령성변화,병진행상관위험인소분석. 방법 연구대상공229례,분위＜80세조화≥80세조,배제진단위만성신장병적환자.측정뇨상규、혈기항、혈뇨소、뇨β2미구단백(β2-MG)、뇨α1미구단백(α1-MG)；근거Cockcroft-Gault공식계산고측신소구려과솔(eGFR).총결년령여상술지표적상관관계,병대상관위험인소진행다인소Logistic회귀분석. 결과 229례환자평균년령(76±10)세,기중＜80세조142례,≥80세조87례.여＜80세조비교,≥80세조eGFR수평명현강저,분별위(80.3±18.0)ml/min비(55.0±12.7)ml/min(t=9.882,P＜0.01)；뇨비중명현강저(1.016±0.006비1.013±0.006)；뇨pH치(6.2±0.8비6.6±0.8)、뇨β2-MG[(0.96±1.02)mg/L비(2.08±3.56) mg/L]화뇨α1-MG[(6.67±3.57)mg/L비(8.71±6.59)mg/L]칙명현승고,차이균유통계학의의.상관분석결과현시,eGFR화뇨비중여환자년령분별정명현부상관(r=0.692화r=-0.280,P＜0.01),여뇨pH치(r=0.255)、뇨32-MG(r=0.262)화뇨α1 MG(r=0.228)정명현정상관(균P＜0.01).다인소Logistic회귀분석현시관심병위신소관공능진전적독립위험인소(OR=4.251,P=0.002). 결론 고령노년남성환자신소관공능수착년령적증장이명현감퇴,관심병시신소관공능진전적독립위험인소.
Objective To summarize the age-related changes and the risk factors of renal tubular function in the elderly male cases.Methods Totally 229 cases without chronic kidney disease were divided into two groups:group aged ＜80 years and group aged ≥80 years.We measured the urine routine,serum creatine,serum urea,urine β2-microglobin (β2-MG),urine α1-microglobin (α1-MG)and calculated the eGFR based on Cockcroft-Gault equation.Logistic regression was used to analyze the risk factors which may accelerate the progression of the renal tubular impairment.Results The average age of 229 cases was (76±10)years.There were 142 cases in the group of ＜80 years old and 87 cases in the group of ≥80 years old.The level of eGFR in the group of ≥80 years old was (55.0±12.7) ml/min,which was lower than that of the group of ＜ 80 years old (80.3 ± 18.0 ml/min) (t =9.882,P＜0.01).The level of urine SG was decreased in the group of ≥80 years old versus in the group of ＜80 years old(1.016±0.006 vs.1.013±0.006).The value changes of urine pH,urine β2-MG and urine α1-MG were of statistical differences between the two groups [(6.2±0.8) vs.(6.6±0.8),(0.96±1.02)mg/L vs.(2.08 ±3.56)mg/L,(6.67±3.57) mg/L vs.(8.71±6.59)mg/L].The correlation analysis showed that age correlated negatively with eGFR and urine SG(r =-0.692and r=-0.280,both P＜0.01)and positively with urine pH(r=0.255),urine β2 MG(r=0.262),urine α1-MG(r=0.228)(all P＜0.01).The Logistic regression analysis showed that coronary heart disease was an independent risk factor for the progression of renal tubular impairment (OR=4.251,P=0.002).Conclusions Renal tubular functions is decreased with ageing age in the elderly male,especially in the advanced elderly.The coronary heart disease is an independent risk factor of the progression of renal tubular impairment.
