中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
12期
1048-1050
,共3页
急性冠状动脉综合征%降血脂药
急性冠狀動脈綜閤徵%降血脂藥
급성관상동맥종합정%강혈지약
Acute coronary syndrome%Antilipemic agents
目的 观察不同剂量阿托伐他汀治疗老年人急性冠状动脉综合征(ACS)的临床治疗效果.方法 选择2010年1月至2012年1月我院心内科收治的老年ACS患者78例,随机分为阿托伐他汀治疗低剂量组和高剂量组,各39例.比较治疗前后患者三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)等指标的变化,记录治疗过程中不良反应的发生情况.结果 治疗前,低剂量组和高剂量组TG、TC、LDL-C和HDL-C比较,差异无统计学意义(P＞0.05).治疗1个月、3个月、6个月和12个月后,两组TC和LDL-C均有不同程度的降低,与治疗前比较差异均有统计学意义(P＜0.05),且高剂量组明显低于低剂量组,差异有统计学意义(P＜0.05);治疗3个月、6个月和12个月后,两组TG均有不同程度的降低,与治疗前比较差异有统计学意义(P＜0.05),高剂量组低于低剂量组,差异有统计学意义(P＜0.05);治疗1个月、3个月、6个月和12个月后,两组患者的HDL-C变化差异无统计学意义(P＞0.05).低剂量组患者出现心血管事件的几率显著高于高剂量组(25.6％比10.3％),差异有统计学意义(P＜0.01).低剂量组不良反应的发生率与高剂量组比较,差异无统计学意义(P＞0.05).结论 高剂量阿托伐他汀治疗老年人ACS的临床效果较好,能较好地降低患者血脂指标,而且能有效减少心血管事件发生率,安全性较好,值得临床应用.
目的 觀察不同劑量阿託伐他汀治療老年人急性冠狀動脈綜閤徵(ACS)的臨床治療效果.方法 選擇2010年1月至2012年1月我院心內科收治的老年ACS患者78例,隨機分為阿託伐他汀治療低劑量組和高劑量組,各39例.比較治療前後患者三酰甘油(TG)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)和高密度脂蛋白膽固醇(HDL-C)等指標的變化,記錄治療過程中不良反應的髮生情況.結果 治療前,低劑量組和高劑量組TG、TC、LDL-C和HDL-C比較,差異無統計學意義(P＞0.05).治療1箇月、3箇月、6箇月和12箇月後,兩組TC和LDL-C均有不同程度的降低,與治療前比較差異均有統計學意義(P＜0.05),且高劑量組明顯低于低劑量組,差異有統計學意義(P＜0.05);治療3箇月、6箇月和12箇月後,兩組TG均有不同程度的降低,與治療前比較差異有統計學意義(P＜0.05),高劑量組低于低劑量組,差異有統計學意義(P＜0.05);治療1箇月、3箇月、6箇月和12箇月後,兩組患者的HDL-C變化差異無統計學意義(P＞0.05).低劑量組患者齣現心血管事件的幾率顯著高于高劑量組(25.6％比10.3％),差異有統計學意義(P＜0.01).低劑量組不良反應的髮生率與高劑量組比較,差異無統計學意義(P＞0.05).結論 高劑量阿託伐他汀治療老年人ACS的臨床效果較好,能較好地降低患者血脂指標,而且能有效減少心血管事件髮生率,安全性較好,值得臨床應用.
목적 관찰불동제량아탁벌타정치료노년인급성관상동맥종합정(ACS)적림상치료효과.방법 선택2010년1월지2012년1월아원심내과수치적노년ACS환자78례,수궤분위아탁벌타정치료저제량조화고제량조,각39례.비교치료전후환자삼선감유(TG)、총담고순(TC)、저밀도지단백담고순(LDL-C)화고밀도지단백담고순(HDL-C)등지표적변화,기록치료과정중불량반응적발생정황.결과 치료전,저제량조화고제량조TG、TC、LDL-C화HDL-C비교,차이무통계학의의(P＞0.05).치료1개월、3개월、6개월화12개월후,량조TC화LDL-C균유불동정도적강저,여치료전비교차이균유통계학의의(P＜0.05),차고제량조명현저우저제량조,차이유통계학의의(P＜0.05);치료3개월、6개월화12개월후,량조TG균유불동정도적강저,여치료전비교차이유통계학의의(P＜0.05),고제량조저우저제량조,차이유통계학의의(P＜0.05);치료1개월、3개월、6개월화12개월후,량조환자적HDL-C변화차이무통계학의의(P＞0.05).저제량조환자출현심혈관사건적궤솔현저고우고제량조(25.6％비10.3％),차이유통계학의의(P＜0.01).저제량조불량반응적발생솔여고제량조비교,차이무통계학의의(P＞0.05).결론 고제량아탁벌타정치료노년인ACS적림상효과교호,능교호지강저환자혈지지표,이차능유효감소심혈관사건발생솔,안전성교호,치득림상응용.
Objective To observe the effect of different doses of atorvastatin in treating elderly acute coronary syndrome.Methods Totally 78 cases with acute coronary syndrome were randomly divided into two groups:low-dose atorvastatin group and high dose atorvastatin group,39 cases for each.The triacylglycerol (TG),total cholesterol(TC),low-density lipoprotein-cholestrol (LDL-C)and high-density lipoprotein-cholestrol (HDL-C) were compared between before and after the treatment.The adverse drug reactions were observed.Results Before treatment,the levels of TG,TC,LDL-C and HDL-C were not statistic significant between the two groups.After treatment of 1 month,3 months,6 months and 12 months,TC and LDL-C of the two groups were decreased than those before treatment,and TC and LDL-C of high-dose atorvastatin group were lower than those of low-dose atorvastatin group,but HDL-C level was not changed compared with before treatment.After treatment of 3 months,6 months and 12 months,TG levels of the two groups were decreased than those before treatment,and TG of high-dose atorvastatin group were reduced than those of low-dose atorvastatin group.The incidence rate of cardiovascular events of high-dose atorvastatin group was significantly lower than those of low-dose atorvastatin group.There was no difference in the incidence rate of adverse drug reactions between the two groups.Conclusions I(s worthy to apply high-dose atorvastatin in clinical treatment for acute coronary syndrome because of its ability to decrease the levels of TG,TC,LDL C,HDL-C and cardiovascular events.
