中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
2期
224-227
,共4页
刘伟%郝文科%钱芸娟%何文娜
劉偉%郝文科%錢蕓娟%何文娜
류위%학문과%전예연%하문나
前列腺增生%药物治疗依从性
前列腺增生%藥物治療依從性
전렬선증생%약물치료의종성
Prostatic hyperplasia%Medication adherence
目的 观察老年良性前列腺增生(BPH)患者对药物治疗的依从性及其原因. 方法 对我院老年泌尿内科就诊的103例年龄66～93岁,平均(78.2±5.9)岁接受5α还原酶抑制剂(非那雄胺)和(或)α受体阻滞剂(坦索罗辛、多沙唑嗪或特拉唑嗪)治疗的BPH患者随访观察6个月.回顾性分析患者治疗前临床指标、治疗过程的用药情况、用药时间、停药和换药情况及不良反应等资料.结果 共随访103例老年BPH患者,使用α受体阻滞剂者30例(29.1％),使用非那雄胺者25例(24.3％),联合治疗者48例(46.6％).随访患者在药物治疗6个月后药物持有比率为0.89±0.23,依从性好的患者82例(79.6％),停药6例(5.8％),换药7例(6.8％),治疗有效率为73.8％(76例),不良反应发生率12.6％(13例),急性尿潴留发生率15.5％(16例),BPH相关手术发生率为4.9％(5例).非那雄胺治疗患者的药物持有率和依从性好的患者比例均高于α受体阻滞剂治疗和联合治疗患者,但差异无统计学意义(均P＞0.05).依从性好患者治疗有效率高于依从性差者,而不良反应发生率和急性尿潴留发生率均低于依从性差者,差异有统计学意义. 结论 老年BPH患者药物治疗依从性好,可能与药物治疗效果好、不良反应少有关.
目的 觀察老年良性前列腺增生(BPH)患者對藥物治療的依從性及其原因. 方法 對我院老年泌尿內科就診的103例年齡66～93歲,平均(78.2±5.9)歲接受5α還原酶抑製劑(非那雄胺)和(或)α受體阻滯劑(坦索囉辛、多沙唑嗪或特拉唑嗪)治療的BPH患者隨訪觀察6箇月.迴顧性分析患者治療前臨床指標、治療過程的用藥情況、用藥時間、停藥和換藥情況及不良反應等資料.結果 共隨訪103例老年BPH患者,使用α受體阻滯劑者30例(29.1％),使用非那雄胺者25例(24.3％),聯閤治療者48例(46.6％).隨訪患者在藥物治療6箇月後藥物持有比率為0.89±0.23,依從性好的患者82例(79.6％),停藥6例(5.8％),換藥7例(6.8％),治療有效率為73.8％(76例),不良反應髮生率12.6％(13例),急性尿潴留髮生率15.5％(16例),BPH相關手術髮生率為4.9％(5例).非那雄胺治療患者的藥物持有率和依從性好的患者比例均高于α受體阻滯劑治療和聯閤治療患者,但差異無統計學意義(均P＞0.05).依從性好患者治療有效率高于依從性差者,而不良反應髮生率和急性尿潴留髮生率均低于依從性差者,差異有統計學意義. 結論 老年BPH患者藥物治療依從性好,可能與藥物治療效果好、不良反應少有關.
목적 관찰노년량성전렬선증생(BPH)환자대약물치료적의종성급기원인. 방법 대아원노년비뇨내과취진적103례년령66～93세,평균(78.2±5.9)세접수5α환원매억제제(비나웅알)화(혹)α수체조체제(탄색라신、다사서진혹특랍서진)치료적BPH환자수방관찰6개월.회고성분석환자치료전림상지표、치료과정적용약정황、용약시간、정약화환약정황급불량반응등자료.결과 공수방103례노년BPH환자,사용α수체조체제자30례(29.1％),사용비나웅알자25례(24.3％),연합치료자48례(46.6％).수방환자재약물치료6개월후약물지유비솔위0.89±0.23,의종성호적환자82례(79.6％),정약6례(5.8％),환약7례(6.8％),치료유효솔위73.8％(76례),불량반응발생솔12.6％(13례),급성뇨저류발생솔15.5％(16례),BPH상관수술발생솔위4.9％(5례).비나웅알치료환자적약물지유솔화의종성호적환자비례균고우α수체조체제치료화연합치료환자,단차이무통계학의의(균P＞0.05).의종성호환자치료유효솔고우의종성차자,이불량반응발생솔화급성뇨저류발생솔균저우의종성차자,차이유통계학의의. 결론 노년BPH환자약물치료의종성호,가능여약물치료효과호、불량반응소유관.
Objective To investigate the compliance with medical therapy in elderly patients with benign prostatic hyperplasia (BPH).Methods The BPH patients aged 66 to 93 treated with 5α-reductase inhibitor (finasteride) and/or α-blockers (tamsulosin,doxazosin or terazosin) were followed up for 6 months.The retrospective data,including international prostatic symptom score (IPSS),quality of life (QOL),maximum flow rate (Qmax),prostate volume (PV),the information of medical types,total number of days of medication supplied,discontinuation and switching of therapy,and adverse effects were collected and analyzed.Results In all 103 subjects,30 patients (29.1％) received α-blockers,25 patients (24.3％) received finasteride,and 48 patients (46.6％)received combination therapy.After a follow-up of 6 months,the medication possession ratio (MPR)was 0.89±0.23 with a good-compliance rate (MPR≥0.8),discontinuation rate and switching rate were 79.6％ (82 cases),5.8％ (6 cases) and 6.8％ (7 cases),respectively,while the efficacy rate,the adverse reaction rate,incidence of acute urinary retention (AUR) and incidence of BPH related operations were 73.8％ (76 cases),12.6％ (13 cases),15.5％ (16 cases) and 4.9％ (5 cases),separately.The MPR (0.90±0.24) and good-compliance rate (84.0％) in patients treated with finasteride were both greater than those with α-blockers (0.87 ± 0.25,76.7％) and combination therapy (0.89 ±0.22,79.2％),but with no significant difference.Compared with patients with badcompliance,the efficacy ratio of medical therapy was significant higher in patients with goodcompliance (81.7％ vs.42.9％),while the incidence of adverse effects and AUR were significant fewer (7.3％ vs.33.3％ and 9.8％ vs.38.1％).Conclusions Elderly patients received either monotherapy or combination therapy with finasteride and α-blockers have good-compliance,which might be associated with the good effect of medical therapy and fewer adverse effects.
