CAJ | 학술논문

目的探讨老年男性骨量与左心室质量指数的关系. 方法老年男性370例,平均年龄(76.6±9.3)岁,测定血清生化指标,进行骨密度检测和超声心动图检查,左心室质量指数采用左心室质量/身高2.7法计算所得,根据是否合并左心室肥厚分为:非左心室肥厚组231例,左心室肥厚组139例,两组计量资料均数间比较用独立样本t检验,组间率或构成比比较x2检验.多因素分析采用多元逐步回归法. 结果血清肌酐水平左心室肥厚组(97.1±43.0)μmol/L,高于非左心室肥厚组(88.2±21.1)μmol/L (P＜0.05)；左心室肥厚组各腰椎骨密度低于非左心室肥厚组,第1腰椎(0.90±0.16)g/cm2与(0.95±0.21)g/cm2 (P=0.05),第2腰椎(0.95±0.17)g/cm2与(1.01±0.20)g/cm2(P＜0.01),第3腰椎(0.99±0.19)g/cm2与(1.06±0.28)g/cm2 (P＜0.01),左心室肥厚组腰椎平均骨密度低于非左心室肥厚组(0.97±0.18)g/cm2与(1.03±0.26)g/cm2 (P＜0.05)；股骨骨量比较,左心室肥厚组近端Inter区、大转子骨密度低于非左心室肥厚组,Inter区(1.00±0.17)g/cm2与(1.05±0.22) g/cm2 (P＜0.05)；大转子(0.64±0.11 g/cm2)与(0.67±0.17)g/cm2 (P＜0.05).以左心室质量指数为因变量,多元线性回归分析逐步筛选结果显示,体质指数(r=0.27,P＜0.01)、腰椎骨密度(r=-0.20,P＜0.01)、年龄(r=0.16,P＜0.01)和血清肌酐(r=0.15,P＜0.05)与左心室质量指独立相关. 结论老年男性人群中,腰椎骨密度与左心室质量指数独立相关.
목적 탐토노년남성골량여좌심실질량지수적관계. 방법 노년남성370례,평균년령(76.6±9.3)세,측정혈청생화지표,진행골밀도검측화초성심동도검사,좌심실질량지수채용좌심실질량/신고2.7법계산소득,근거시부합병좌심실비후분위:비좌심실비후조231례,좌심실비후조139례,량조계량자료균수간비교용독립양본t검험,조간솔혹구성비비교x2검험.다인소분석채용다원축보회귀법. 결과 혈청기항수평좌심실비후조(97.1±43.0)μmol/L,고우비좌심실비후조(88.2±21.1)μmol/L (P＜0.05)；좌심실비후조각요추골밀도저우비좌심실비후조,제1요추(0.90±0.16)g/cm2여(0.95±0.21)g/cm2 (P=0.05),제2요추(0.95±0.17)g/cm2여(1.01±0.20)g/cm2(P＜0.01),제3요추(0.99±0.19)g/cm2여(1.06±0.28)g/cm2 (P＜0.01),좌심실비후조요추평균골밀도저우비좌심실비후조(0.97±0.18)g/cm2여(1.03±0.26)g/cm2 (P＜0.05)；고골골량비교,좌심실비후조근단Inter구、대전자골밀도저우비좌심실비후조,Inter구(1.00±0.17)g/cm2여(1.05±0.22) g/cm2 (P＜0.05)；대전자(0.64±0.11 g/cm2)여(0.67±0.17)g/cm2 (P＜0.05).이좌심실질량지수위인변량,다원선성회귀분석축보사선결과현시,체질지수(r=0.27,P＜0.01)、요추골밀도(r=-0.20,P＜0.01)、년령(r=0.16,P＜0.01)화혈청기항(r=0.15,P＜0.05)여좌심실질량지독립상관. 결론 노년남성인군중,요추골밀도여좌심실질량지수독립상관.
Objective To investigate the association between bone mineral density (BMD) and left ventricular mass index (LVMI) in elderly men in Beijing.Methods Totally 370 elderly men with an average age of (76.6±9.3) years from the departments of gerontology were included.BMD,echocardiography measurements as well as blood chemistry were analyzed.LVMI was obtained by echocardiography.All the subjects were divided into two groups:non-LVH group (n=231) and LVH group (n =139).Differences in quantitative variables were tested by independent-sample t test.Multiple stepwise linear regression analysis were performed to identify determinants of LVMI.Results The serum creatinine concentration was significantly higher in LVH group than in non-LVH group [(97.1±43.0) μmol/L,(88.2±21.1) μmol/L (P＜0.05)].Compared with non-LVH group,LVH group showed that the lumbar spine BMD (L1-L4) were significantly lower[L1:(0.90±0.16) g/cm2 vs.(0.95±0.21) g/cm2,P=0.05; L2:(0.95±0.17) g/cm2 vs.(1.01±0.20) g/cm2,P＜0.01 ; L3:(0.99±0.19) g/cm2 vs.(1.06±0.28) g/cm2,P＜0.01] as well as the lumbar spine totalBMD [(0.97±0.18) g/cm2 vs.(1.03-1-0.26) g/cm2,P＜0.05].The femur BMD was lower in theLVH group than in non-LVH group [trochiter:(0.64±0.11) g/cm2 vs.(0.67±0.17) g/cm2,P＜0.05; inter area:(1.00±0.17) g/cm2 vs.(1.05±0.22) g/cm2,P＜0.05].Multiple stepwise linear regression analysis demonstrated that BMI (r=0.27,P＜0.01),the lumbar spine BMD (r=-0.20,P＜0.01),age (r=0.16,P＜0.05),serum creatinine (r=0.15,P＜0.05) were independently correlated with LVMI.Conclusions In elderly men in Beijing,the lumbar spine BMD is an independent correlative factor for LVMI.