中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
4期
365-367
,共3页
郭环宇%黄浩%郁建迪%祝世法
郭環宇%黃浩%鬱建迪%祝世法
곽배우%황호%욱건적%축세법
前列腺增生%胰岛素抗药性
前列腺增生%胰島素抗藥性
전렬선증생%이도소항약성
Prostatic hyperplasia%Insulin resistence
目的 探讨胰岛素抵抗与不同年龄段老年人良性前列腺增生的相关性. 方法 选取2012年1月至6月在我院门诊的老年前列腺增生患者100例.根据年龄分为60～75岁组52例和76～93岁组48例,测定空腹血糖、空腹胰岛素、血清前列腺特异性抗原(PSA)等,运用稳态模型胰岛素抵抗指数(HOMA2-IR)软件计算胰岛素抵抗指数(IRI)；测量身高、体质量、腰围并计算体质指数,测定前列腺体积,比较两组临床资料,根据HOMA2-IR分为胰岛素抵抗(IR＞1.7)组和非胰岛素抵抗(IR＜1.7)组,并比较两组前列腺特异性抗原、前列腺体积和腰围. 结果 IR＞ 1.7)与IR＜ 1.7组腰围(96.6±7.2) cm与(93.1±8.9)cm(P＜0.01)和前列腺体积(50.0±9.0) ml与(46.1±7.8)ml比较,差异有统计学意义(均P＜0.05)；而前列腺特异性抗原值较低,差异有统计学意义(P＜0.05).HOMA2-IR与前列腺体积无相关性.76～79岁组患者前列腺特异性抗原与前列腺体积、HOMA2-IR无相关性；60～75岁组前列腺特异性抗原与前列腺体积呈正相关(r=0.52,P＜0.05),与HOMA2-IR呈负相关(r=-0.38,P＜0.05). 结论 年龄≤75岁的老年BPH患者前列腺特异性抗原与前列腺体积呈正相关,与胰岛素抵抗呈负相关.
目的 探討胰島素牴抗與不同年齡段老年人良性前列腺增生的相關性. 方法 選取2012年1月至6月在我院門診的老年前列腺增生患者100例.根據年齡分為60～75歲組52例和76～93歲組48例,測定空腹血糖、空腹胰島素、血清前列腺特異性抗原(PSA)等,運用穩態模型胰島素牴抗指數(HOMA2-IR)軟件計算胰島素牴抗指數(IRI)；測量身高、體質量、腰圍併計算體質指數,測定前列腺體積,比較兩組臨床資料,根據HOMA2-IR分為胰島素牴抗(IR＞1.7)組和非胰島素牴抗(IR＜1.7)組,併比較兩組前列腺特異性抗原、前列腺體積和腰圍. 結果 IR＞ 1.7)與IR＜ 1.7組腰圍(96.6±7.2) cm與(93.1±8.9)cm(P＜0.01)和前列腺體積(50.0±9.0) ml與(46.1±7.8)ml比較,差異有統計學意義(均P＜0.05)；而前列腺特異性抗原值較低,差異有統計學意義(P＜0.05).HOMA2-IR與前列腺體積無相關性.76～79歲組患者前列腺特異性抗原與前列腺體積、HOMA2-IR無相關性；60～75歲組前列腺特異性抗原與前列腺體積呈正相關(r=0.52,P＜0.05),與HOMA2-IR呈負相關(r=-0.38,P＜0.05). 結論 年齡≤75歲的老年BPH患者前列腺特異性抗原與前列腺體積呈正相關,與胰島素牴抗呈負相關.
목적 탐토이도소저항여불동년령단노년인량성전렬선증생적상관성. 방법 선취2012년1월지6월재아원문진적노년전렬선증생환자100례.근거년령분위60～75세조52례화76～93세조48례,측정공복혈당、공복이도소、혈청전렬선특이성항원(PSA)등,운용은태모형이도소저항지수(HOMA2-IR)연건계산이도소저항지수(IRI)；측량신고、체질량、요위병계산체질지수,측정전렬선체적,비교량조림상자료,근거HOMA2-IR분위이도소저항(IR＞1.7)조화비이도소저항(IR＜1.7)조,병비교량조전렬선특이성항원、전렬선체적화요위. 결과 IR＞ 1.7)여IR＜ 1.7조요위(96.6±7.2) cm여(93.1±8.9)cm(P＜0.01)화전렬선체적(50.0±9.0) ml여(46.1±7.8)ml비교,차이유통계학의의(균P＜0.05)；이전렬선특이성항원치교저,차이유통계학의의(P＜0.05).HOMA2-IR여전렬선체적무상관성.76～79세조환자전렬선특이성항원여전렬선체적、HOMA2-IR무상관성；60～75세조전렬선특이성항원여전렬선체적정정상관(r=0.52,P＜0.05),여HOMA2-IR정부상관(r=-0.38,P＜0.05). 결론 년령≤75세적노년BPH환자전렬선특이성항원여전렬선체적정정상관,여이도소저항정부상관.
Objective To explore the relationship between insulin resistance (IR) and benign prostatic hyperplasia (BPH) in elderly men of different ages.Methods Totally 100 elderly outpatients with BPH in our hospital from January 2012 to June 2012 were recruited in this study.All patients were divided into 2 groups according to age:60-75 years(n =52) and 76-93 years (n=48).Fasting plasma glucose,fasting insulin (FINS) and prostate specific antigen (PSA) were assayed.Insulin resistance index (IRI) was calculated by using the homeostasis model assessment-insulin resistance (HOMA2-IR) software.The body height,body weight,waist circumference were measured and the body mass index (BMI) was calculated.Prostate volume (PV) was measured by abdominal ultrasound.Clinical data were compared between the two groups.Based on HOMA2-IR,patients were divided into insulin resistant group (IR＞ 1.7) and non insulin resistant group (IR＜ 1.7).Serum PSA,PV and waist circumference were compared between the two groups.Results The waist circumference and PV were significantly larger in insulin resistant group than in non-insulin resistant group [(96.6± 7.2) cm vs.(93.1±8.9) cm,(50.0±9.0) ml vs.(46.1±7.8) ml,respectively,P＜0.01,0.05].However,the PSA level was lower in insulin resistant group than in non-insulin resistant group [(1.44±1.08) μg/L vs.(2.1 ±2.0)μg/L,P＜0.05],and no correlation was found between HOMA-IR and PV.There was no correlation between serum PSA levels and PV in patients aged 76-93 years.In patients aged 60-75 years,PSA level was positively correlated with PV (r =0.52,P＜0.05) and negatively correlated with HOMA-IR (r=0.38,P＜0.05).Conclusions Serum PSA level is positively correlated with PV and negatively correlated with HOMA IR in BPH patients under 75 years old.
