CAJ | 학술논문

目的探讨尼可地尔对老年冠状动脉慢血流(CSFP)的干预效果及其对血管内皮的保护作用. 方法选择经冠状动脉造影诊断为冠状动脉慢血流老年患者76例,随机抽签分为尼可地尔治疗组38例(常规治疗+尼可地尔)与常规治疗组38例.采用校正的急性心肌梗死溶栓试验(TIMI)血流分级帧数法(CTFC)方法评价冠状动脉血流速度.分别测定两组患者基线、治疗1个月、治疗3个月时血浆中内皮素-1和一氧化氮水平.采用重复测量方差分析对相应指标进行分析比较.结果治疗3个月后,尼可地尔组一氧化氮水平较常规治疗组高,内皮素-1水平较常规治疗组低.尼可地尔治疗组在治疗3个月时一氧化氮水平为(34.6±6.0)μmol/L,较治疗前(25.8±7.9) μmol/L升高(P＜0.01)；尼可地尔治疗组在治疗3个月时内皮素-1水平(18.6±6.5)ng/L较治疗前(21.5±6.7)ng/L降低(P＜0.01). 结论在常规治疗基础上加用尼可地尔能改善血管内皮功能,对老年CSFP患者治疗有效.
목적 탐토니가지이대노년관상동맥만혈류(CSFP)적간예효과급기대혈관내피적보호작용. 방법 선택경관상동맥조영진단위관상동맥만혈류노년환자76례,수궤추첨분위니가지이치료조38례(상규치료+니가지이)여상규치료조38례.채용교정적급성심기경사용전시험(TIMI)혈류분급정수법(CTFC)방법평개관상동맥혈류속도.분별측정량조환자기선、치료1개월、치료3개월시혈장중내피소-1화일양화담수평.채용중복측량방차분석대상응지표진행분석비교.결과 치료3개월후,니가지이조일양화담수평교상규치료조고,내피소-1수평교상규치료조저.니가지이치료조재치료3개월시일양화담수평위(34.6±6.0)μmol/L,교치료전(25.8±7.9) μmol/L승고(P＜0.01)；니가지이치료조재치료3개월시내피소-1수평(18.6±6.5)ng/L교치료전(21.5±6.7)ng/L강저(P＜0.01). 결론 재상규치료기출상가용니가지이능개선혈관내피공능,대노년CSFP환자치료유효.
Objective To observe the effects of nicorandil on coronary slow flow phenomenon (CSFP) and endothelial function in elderly patients.Methods Totally 76 elderly patients diagnosed angiographically as coronary slow flow phenomenon were enrolled.All patients were randomly divided into two groups:CSFP nicorandil group (n=38,treated with traditional treatment+ nicorandil) or CSFP traditional group (n=38,treated with traditional treatment).Coronary flow patterns in patients were assessed by corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC).The levels of plasma endothelin (ET)-1 and nitric oxide (NO) in the two groups were measured at baseline,1 month and 3 months after the treatment.Repeated measures ANOVA was used to analyze the differences between the two groups.Results The plasma NO level was significantly higher in CSFP nicorandil group than in CSFP traditional group,and the plasma ET-1 level was significantly lower in CSFP nicorandil group than in CSFP traditional group 3 months after treatment.There were significant differences in the plasma levels of NO and ET-1 in CSFP nicorandil group between the pre-and post-treatment[(25.8±7.9) μmol/L vs.(34.6±6.0) μmol/L,(21.5±6.7) ng/L vs.(18.6 ±6.5) ng/L,respectively,P＜0.01].Conclusions Combination of conventional therapy with nicorandil can significantly improve the endothelial function,so it is an effective treatment for CSFP in elderly patients.