中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
6期
582-585
,共4页
李侠%郭燕%胡有东%陈颖%郭殿选%周华兰%杨海晨%李霞
李俠%郭燕%鬍有東%陳穎%郭殿選%週華蘭%楊海晨%李霞
리협%곽연%호유동%진영%곽전선%주화란%양해신%리하
脐血干细胞移植%心肌梗死%血小板膜糖蛋白类
臍血榦細胞移植%心肌梗死%血小闆膜糖蛋白類
제혈간세포이식%심기경사%혈소판막당단백류
Cord blood stem cell transplantation%Myocardial infarction%Platelet membrane glycoproteins
目的 探讨人脐带间充质干细胞(hUCM-SCs)治疗老年人陈旧性心肌梗死对血小板糖蛋白CD61(CD61)、CD62P和内皮细胞黏附分子CD54 (CD54)的影响. 方法 采用流式细胞仪检测经皮冠状动脉介入治疗+支架置入术(对照组,15例)和冠状动脉介入治疗+支架置入术+hUCM-SCs移植术(实验组,15例)患者的外周血CD61、CD62P和CD54表达水平与心肌梗死面积和左心室射血分数(LVEF)的关系. 结果 对照组术后8周梗死面积(26.6±3.4)％、LVEF(38.4±2.8)％；实验组移植后8周(24.2±3.9)％、LVEF(47.3±4.1)％,两组比较差异有统计学意义(均P＜0.05).对照组术后8周CD61为(23.6±0.6)％、CD62P为(14.2±2.8)％、CD54为(15.3±1.3)％；实验组移植后8周CD61为(28.3±0.9)％、CD62P为(10.5±1.2)％、CD54为(11.2±0.8)％,两组CD61水平比较差异有统计学意义(P＜0.05),实验组移植后8周CD62P和CD54水平低于对照组(均P＜0.05). 结论 CD61、CD62P和CD54表达水平变化与hUCM-SCs移植患者梗死面积的缩小和LVEF改善相关.
目的 探討人臍帶間充質榦細胞(hUCM-SCs)治療老年人陳舊性心肌梗死對血小闆糖蛋白CD61(CD61)、CD62P和內皮細胞黏附分子CD54 (CD54)的影響. 方法 採用流式細胞儀檢測經皮冠狀動脈介入治療+支架置入術(對照組,15例)和冠狀動脈介入治療+支架置入術+hUCM-SCs移植術(實驗組,15例)患者的外週血CD61、CD62P和CD54錶達水平與心肌梗死麵積和左心室射血分數(LVEF)的關繫. 結果 對照組術後8週梗死麵積(26.6±3.4)％、LVEF(38.4±2.8)％；實驗組移植後8週(24.2±3.9)％、LVEF(47.3±4.1)％,兩組比較差異有統計學意義(均P＜0.05).對照組術後8週CD61為(23.6±0.6)％、CD62P為(14.2±2.8)％、CD54為(15.3±1.3)％；實驗組移植後8週CD61為(28.3±0.9)％、CD62P為(10.5±1.2)％、CD54為(11.2±0.8)％,兩組CD61水平比較差異有統計學意義(P＜0.05),實驗組移植後8週CD62P和CD54水平低于對照組(均P＜0.05). 結論 CD61、CD62P和CD54錶達水平變化與hUCM-SCs移植患者梗死麵積的縮小和LVEF改善相關.
목적 탐토인제대간충질간세포(hUCM-SCs)치료노년인진구성심기경사대혈소판당단백CD61(CD61)、CD62P화내피세포점부분자CD54 (CD54)적영향. 방법 채용류식세포의검측경피관상동맥개입치료+지가치입술(대조조,15례)화관상동맥개입치료+지가치입술+hUCM-SCs이식술(실험조,15례)환자적외주혈CD61、CD62P화CD54표체수평여심기경사면적화좌심실사혈분수(LVEF)적관계. 결과 대조조술후8주경사면적(26.6±3.4)％、LVEF(38.4±2.8)％；실험조이식후8주(24.2±3.9)％、LVEF(47.3±4.1)％,량조비교차이유통계학의의(균P＜0.05).대조조술후8주CD61위(23.6±0.6)％、CD62P위(14.2±2.8)％、CD54위(15.3±1.3)％；실험조이식후8주CD61위(28.3±0.9)％、CD62P위(10.5±1.2)％、CD54위(11.2±0.8)％,량조CD61수평비교차이유통계학의의(P＜0.05),실험조이식후8주CD62P화CD54수평저우대조조(균P＜0.05). 결론 CD61、CD62P화CD54표체수평변화여hUCM-SCs이식환자경사면적적축소화LVEF개선상관.
Objective To study the effects of human umbilical cord mesenchymal stem cells (hUCM-SCs) therapy on peripheral blood CD61,CD62P and CD54 in elderly patients with old myocardial infarction.Methods From July 2010 to August 2012,30 elderly patients with old myocardial infarction were randomly selected.Patients were divided into the control group (n=15),treated with percutaneous coronary intervention (PCI) and stent implantation,and the experimental group (n=15),treated with PCI,stent implantation and hUC-MSCs transplantation.The expression levels of peripheral blood CD61,CD62P and CD54 were measured by flow cytometry.The correlation between the levels of CD61,CD62P and CD54 and the infarct size,left ventricular ejection fraction (LVEF) were evaluated.Results After 8 weeks of treatment,there were significant differences in infarct size and LVEF between the control group and the experimental group [(26.6±3.4)％ vs.(24.2±3.9) ％,(38.4±2.8)％ vs.(47.3±4.1)％,respectively,both P＜0.05].The CD61 level was higher in the experimental group than in the control group [(28.3±0.9)％ vs.(23.6±0.6)％,P＜0.05].The levels of CD62P and CD54 were lower in the experimental group than in the control group[(10.5±1.2)％ vs.(14.2±2.8)％,(11.2±0.8)％ vs.(15.3±1.3)％,respectively,bothP ＜0.05].Conclusions The changes in CD61,CD62P,CD54 expressions are correlated with decrease of myocardial infarction size and improvement of LVEF in elderly patients with old myocardial infarction.
