中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
7期
714-716
,共3页
于恩彦%吴万振%任爱华%朱利月%周建妹%王强
于恩彥%吳萬振%任愛華%硃利月%週建妹%王彊
우은언%오만진%임애화%주리월%주건매%왕강
认知障碍%阿尔茨海默病%细胞因子类
認知障礙%阿爾茨海默病%細胞因子類
인지장애%아이자해묵병%세포인자류
Cognition disorders%Alzheimer disease%Cytokines
目的 研究轻度认知障碍(MCI)患者外周血中促炎细胞因子浓度与认知功能的动态变化关系. 方法 搜集MCI患者70例,评估患者的认知功能,动态随访采集患者静脉血,利用酶联免疫吸附试验检测促炎细胞因子肿瘤坏死因子α(TNF α)、白细胞介素(IL)-1α、IL1β和IL-6的浓度. 结果 70例MCI患者,符合遗忘型MCI(aMCI)标准的50例,其中19例进展为阿尔茨海默病(AD).1 9例进展为AD的aMCI患者疾病进展前与进展后细胞因子IL-1β[(40.5±7.7和38.6±7.3) μg/L,t=3.537、P=0.002],IL-6[(70.4±24.3和53.6±20.5)μg/L,t=2.229、P=0.039]和TNF-α[(58.6±13.5和50.3±17.1)μg/L,t=2.226、P=0.039]差异有统计学意义. 结论 MCI患者进展为AD后IL-1β、IL-6和TNF α含量均降低.
目的 研究輕度認知障礙(MCI)患者外週血中促炎細胞因子濃度與認知功能的動態變化關繫. 方法 搜集MCI患者70例,評估患者的認知功能,動態隨訪採集患者靜脈血,利用酶聯免疫吸附試驗檢測促炎細胞因子腫瘤壞死因子α(TNF α)、白細胞介素(IL)-1α、IL1β和IL-6的濃度. 結果 70例MCI患者,符閤遺忘型MCI(aMCI)標準的50例,其中19例進展為阿爾茨海默病(AD).1 9例進展為AD的aMCI患者疾病進展前與進展後細胞因子IL-1β[(40.5±7.7和38.6±7.3) μg/L,t=3.537、P=0.002],IL-6[(70.4±24.3和53.6±20.5)μg/L,t=2.229、P=0.039]和TNF-α[(58.6±13.5和50.3±17.1)μg/L,t=2.226、P=0.039]差異有統計學意義. 結論 MCI患者進展為AD後IL-1β、IL-6和TNF α含量均降低.
목적 연구경도인지장애(MCI)환자외주혈중촉염세포인자농도여인지공능적동태변화관계. 방법 수집MCI환자70례,평고환자적인지공능,동태수방채집환자정맥혈,이용매련면역흡부시험검측촉염세포인자종류배사인자α(TNF α)、백세포개소(IL)-1α、IL1β화IL-6적농도. 결과 70례MCI환자,부합유망형MCI(aMCI)표준적50례,기중19례진전위아이자해묵병(AD).1 9례진전위AD적aMCI환자질병진전전여진전후세포인자IL-1β[(40.5±7.7화38.6±7.3) μg/L,t=3.537、P=0.002],IL-6[(70.4±24.3화53.6±20.5)μg/L,t=2.229、P=0.039]화TNF-α[(58.6±13.5화50.3±17.1)μg/L,t=2.226、P=0.039]차이유통계학의의. 결론 MCI환자진전위AD후IL-1β、IL-6화TNF α함량균강저.
Objective To investigate the relationship between proinflammatory cytokines and cognitive function in patients with mild cognitive impairment (MCI).Methods From May 2007 to May 2009,70 patients (aged ≥ 60 years) with MCI were collected.Among them,50 cases were amnestic MCI,and 19 cases developed into AD.The cognitive function was assessed,and all patients were followed up.The venous blood samples were obtained and proinflammatory cytokines (IL-1α,IL 1β,IL-6,TNF-α) were detected by using enzyme linked immunosorbent assay.Results There were differences in the levels of proinflammatory cytokines between patients with aMCI and patients with Alzheimer's disease (AD) [IL-1β,(40.5 ± 7.7) μg/L vs.(38.6 ± 7.3) μg/L ; IL 6,(70.4 ±24.3) μg/'L vs.(53.6±20.5) μg/L;TNF-α,(58.6±13.5) μg/'L vs.(50.3±-17.1) μg/'L;t=3.537,2.229,2.226,P=0.002,0.039,0.039,respectively].Conclusions MCI is a preclinical state of AD.The cognitive function damage of MCI patients are different from that of AD patients,and the immune status of MCI patients is also changed.
