CAJ | 학술논문

目的观察不同牙周治疗方法对老年冠心病患者血清炎性因子C-反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)水平的影响.方法选择患有重度牙周炎的老年冠心病患者42例,随机分为两组,对照组进行牙周基础治疗,实验组患者接受基础治疗和翻瓣术.治疗前和治疗后12周分别记录其探诊出血牙面的百分比；探诊深度,CRP和TNF-α水平.结果两组患者治疗后12周与基线比较各项指标降低(均P＜0.05).治疗后12周实验组牙周指标低于对照组,差异有统计学意义；实验组TNF-α为(2.6±7.9)μg/L,CRP为(3.5±2.1) mg/L,对照组分别为(3.4±9.1)μg/L和(4.4±1.8) mg/L,实验组低于对照组(P＜0.05).结论相对于牙周基础治疗,翻瓣术更能降低老年人冠心病相关血清炎性标记物CRP和TNF-α的水平.
목적 관찰불동아주치료방법대노년관심병환자혈청염성인자C-반응단백(CRP)화종류배사인자α(TNF-α)수평적영향.방법 선택환유중도아주염적노년관심병환자42례,수궤분위량조,대조조진행아주기출치료,실험조환자접수기출치료화번판술.치료전화치료후12주분별기록기탐진출혈아면적백분비；탐진심도,CRP화TNF-α수평.결과 량조환자치료후12주여기선비교각항지표강저(균P＜0.05).치료후12주실험조아주지표저우대조조,차이유통계학의의；실험조TNF-α위(2.6±7.9)μg/L,CRP위(3.5±2.1) mg/L,대조조분별위(3.4±9.1)μg/L화(4.4±1.8) mg/L,실험조저우대조조(P＜0.05).결론 상대우아주기출치료,번판술경능강저노년인관심병상관혈청염성표기물CRP화TNF-α적수평.
Objective To observe the effect of two different periodontal therapies on serum levels of C-reactive protein (CRP) and tumor necrosis factor-alpha(TNF-α)in elderly patients with coronary heart disease.Methods Totally 42 elderly patients with severe periodontitis were randomized into two groups:periodontal initial therapy and periodontal flap surgery group.The percentage of bleeding on probing (BOP),probing depth (PD) and serum levels of CRP and TNF-α were recorded at baseline and 12 weeks after treatment.Results The percentage of BOP,PD and serum levels of CRP and TNF-α in all patients were significantly reduced at 12 weeks after treatment as compared with baseline (all P＜0.05).Serum levels of CRP and TNF-α were lower in periodontal flap surgery than in periodontal initial therapy at 12 weeks after treatment [(3.4±9.1) μg/L vs.(2.6 ±7.9)μg/L,(4.4±1.8)mg/L vs.(3.5±2.1)mg/L,both P＜0.05].Conclusions Compared with periodontal initial therapy,periodontal flap surgery maybe better to reduce the levels of serum inflammatory markers.