中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
8期
897-901
,共5页
屈亚莉%孔丽华%田雨%郭小灵%李守华%屈克义%李祖铭
屈亞莉%孔麗華%田雨%郭小靈%李守華%屈剋義%李祖銘
굴아리%공려화%전우%곽소령%리수화%굴극의%리조명
尿酸%代谢综合征X
尿痠%代謝綜閤徵X
뇨산%대사종합정X
Uric acid%Metabolic syndrome X
目的 探讨中老年人群血尿酸水平与代谢综合征(MS)之间的关系,并探讨年龄及性别因素对其关系的影响.方法 于2007年在宜昌市夷陵区的35岁及以上男女性农村自然人群中进行现况调查,包括问卷、体检、生化指标测定等.根据最新指南确定MS的诊断标准.研究对象按血尿酸水平四分位和不同年龄(35～岁、45～岁、≥60岁)联合分组,探讨年龄、血尿酸水平和MS的关系.结果 共纳入研究对象9354例,男性3883例,女性5471例,≥60岁者男性和女性所占比例分别为21.1％和17.4％.男性血尿酸水平第1～4分位者MS患病率分别为3.8％、5.5％、7.9％和15.2％,女性分别为3.1％、5.5％、7.9％和16.7％.调整其他混杂因素后,男女性血尿酸水平仍与MS呈明显正相关.按年龄与血尿酸水平联合分组后,Logistic回归分析发现随着年龄和血尿酸水平的增加,女性罹患MS的风险均呈明显增加趋势.而在男性中,年龄、血尿酸水平与MS相关程度明显弱于女性.结论 血尿酸水平与MS呈正相关,女性的年龄、血尿酸水平与MS的相关强度高于男性.高血尿酸水平的中老年女性患MS风险最高.
目的 探討中老年人群血尿痠水平與代謝綜閤徵(MS)之間的關繫,併探討年齡及性彆因素對其關繫的影響.方法 于2007年在宜昌市夷陵區的35歲及以上男女性農村自然人群中進行現況調查,包括問捲、體檢、生化指標測定等.根據最新指南確定MS的診斷標準.研究對象按血尿痠水平四分位和不同年齡(35～歲、45～歲、≥60歲)聯閤分組,探討年齡、血尿痠水平和MS的關繫.結果 共納入研究對象9354例,男性3883例,女性5471例,≥60歲者男性和女性所佔比例分彆為21.1％和17.4％.男性血尿痠水平第1～4分位者MS患病率分彆為3.8％、5.5％、7.9％和15.2％,女性分彆為3.1％、5.5％、7.9％和16.7％.調整其他混雜因素後,男女性血尿痠水平仍與MS呈明顯正相關.按年齡與血尿痠水平聯閤分組後,Logistic迴歸分析髮現隨著年齡和血尿痠水平的增加,女性罹患MS的風險均呈明顯增加趨勢.而在男性中,年齡、血尿痠水平與MS相關程度明顯弱于女性.結論 血尿痠水平與MS呈正相關,女性的年齡、血尿痠水平與MS的相關彊度高于男性.高血尿痠水平的中老年女性患MS風險最高.
목적 탐토중노년인군혈뇨산수평여대사종합정(MS)지간적관계,병탐토년령급성별인소대기관계적영향.방법 우2007년재의창시이릉구적35세급이상남녀성농촌자연인군중진행현황조사,포괄문권、체검、생화지표측정등.근거최신지남학정MS적진단표준.연구대상안혈뇨산수평사분위화불동년령(35～세、45～세、≥60세)연합분조,탐토년령、혈뇨산수평화MS적관계.결과 공납입연구대상9354례,남성3883례,녀성5471례,≥60세자남성화녀성소점비례분별위21.1％화17.4％.남성혈뇨산수평제1～4분위자MS환병솔분별위3.8％、5.5％、7.9％화15.2％,녀성분별위3.1％、5.5％、7.9％화16.7％.조정기타혼잡인소후,남녀성혈뇨산수평잉여MS정명현정상관.안년령여혈뇨산수평연합분조후,Logistic회귀분석발현수착년령화혈뇨산수평적증가,녀성리환MS적풍험균정명현증가추세.이재남성중,년령、혈뇨산수평여MS상관정도명현약우녀성.결론 혈뇨산수평여MS정정상관,녀성적년령、혈뇨산수평여MS적상관강도고우남성.고혈뇨산수평적중노년녀성환MS풍험최고.
Objective To explore the relationship between serum uric acid(SUA) levels and metabolic syndrome(MS) in middle-aged and elderly people,and to investigate the impacts of age and gender on the relationship between SUA and MS.Methods A cross-sectional study was carried out in general population aged over 35 years in rural area of Yiling District,Yichang City in 2007.All subjects were investigated by using the standardized questionnaire,physical and biochemical examinations.MS was defined according to the diagnostic criteria of the latest Chinese guidelines.All subjects were divided into different subgroups based on quartiles of SUA levels and age(35-44 years old,45-59 years old,over 60 years old).The relationship of MS with age and SUA levels were investigated.Results 9354 subjects consisted of 3883 males and 5471 females were included in this study.The percentage of subjects aged over 60 years was 21.1％ in men and 17.4％ in women.The prevalence of MS from the first quartile to the fourth quartile were 3.8％,5.5％,7.9％,15.2％ in males,and 3.1％,5.5％,7.9％,16.7％ in females,respectively.The SUA levels was positively correlated with MS in both sexes after adjusting for other confounding factors.By analyzing associated-subgroups based on age and SUA levels,logistic regression analysis showed that the risk of MS was significantly increased with aging and SUA levels in female subjects.The association between age and MS was significantly weaker in men than in women.Conclusions There is a positive correlation between SUA levels and MS.The associations of MS with age and SUA levels are more closely in women than in men.The risk of MS may be highest in middle-aged and elderly women with high level of SUA.
