CAJ | 학술논문

目的探讨情感障碍患者一级亲属中阿尔茨海默病(Alzheimer's disease,AD)患病率,以评估情感障碍家系中AD的患病风险. 方法收集符合“DSM-Ⅳ-TR”诊断标准的情感障碍患者(情感障碍组)及其健康配偶(对照组)各109例,一级亲属入组标准为年龄≥55岁的父母和同胞.对可疑者应用神经心理评估、影像学和临床检查后,再根据美国神经病语言障碍和中风研究所及阿尔茨海默病与相关障碍协会(NINCDS-ADRDA)标准进行AD的诊断. 结果情感障碍组一级亲属284例,对照组一级亲属274例,两组一级亲属平均年龄、性别分布差异无统计学意义.情感障碍患者的284例一级亲属中有10.6％(30/284)被诊断AD,对照组274例一级亲属中有4.4％(12/274)被诊断AD,两组AD患病率差异有统计学意义(x2=7.47,P=0.006);其中,情感障碍各亚型中双相障碍和抑郁障碍患者一级亲属AD患病率分别为11.2％(14/125)和20.0％(15/75),均高于对照组一级亲属AD患病率4.4％(12/274)(x2=6.80、20.56,OR=2.60、4.63,P=0.009、0.001),而躁狂发作患者一级亲属AD患病率为1.1％(1/87),与对照组一级亲属AD患病率4.4％(12/274)比较,差异无统计学意义(x2=1.99,P=0.159). 结论情感障碍患者尤其是抑郁症和双相障碍患者的一级亲属AD患病风险较高.
목적 탐토정감장애환자일급친속중아이자해묵병(Alzheimer's disease,AD)환병솔,이평고정감장애가계중AD적환병풍험. 방법 수집부합“DSM-Ⅳ-TR”진단표준적정감장애환자(정감장애조)급기건강배우(대조조)각109례,일급친속입조표준위년령≥55세적부모화동포.대가의자응용신경심리평고、영상학화림상검사후,재근거미국신경병어언장애화중풍연구소급아이자해묵병여상관장애협회(NINCDS-ADRDA)표준진행AD적진단. 결과 정감장애조일급친속284례,대조조일급친속274례,량조일급친속평균년령、성별분포차이무통계학의의.정감장애환자적284례일급친속중유10.6％(30/284)피진단AD,대조조274례일급친속중유4.4％(12/274)피진단AD,량조AD환병솔차이유통계학의의(x2=7.47,P=0.006);기중,정감장애각아형중쌍상장애화억욱장애환자일급친속AD환병솔분별위11.2％(14/125)화20.0％(15/75),균고우대조조일급친속AD환병솔4.4％(12/274)(x2=6.80、20.56,OR=2.60、4.63,P=0.009、0.001),이조광발작환자일급친속AD환병솔위1.1％(1/87),여대조조일급친속AD환병솔4.4％(12/274)비교,차이무통계학의의(x2=1.99,P=0.159). 결론 정감장애환자우기시억욱증화쌍상장애환자적일급친속AD환병풍험교고.
Objective To investigate the prevalence of Alzheimer's disease (AD) in first-degree relatives of patients with affective disorders,and to evaluate the risk of AD in first-degree relatives of the patients with affective disorders.Methods Patients with affective disorders meeting "DSM-Ⅳ-TR" criteria (affective disorders group) and their healthy spouses (conrol group) were recruited in this study (n=109 each).The first-degree relatives inclusion criteria were biological relatives of both probands aged over 55 years.Subjects were investigated by neuropsychological assessment,imaging and clinical examinations,and were diagnosed as AD according to the criteria of the United States of America neuropathy language disorders and stroke research institute and Alzheimer's disease and Related Disorders Association (NINCDS-ADRDA).Results 284 first-degree biological relatives of affective disorders patients and 274 first-degree relatives of control group were selected.There were no statistically significant differences in demographic characteristics of the first-degree relatives between the two groups.The prevalence of Alzheimer's disease in the first-degree relatives had a significant difference between affective disorders group and control group [10.6％ (30/284) vs.4.4％ (12/ 274),x2=7.47,P=0.006].The prevalence of AD in the first-degree relatives was higher in bipolar disorder and depressive disorder patients than in control group [11.2％ (14/125) vs.4.4％(12/274),20.0％ (15/75) vs.4.4％(12/274),x2=6.80,20.56,OR=2.60,4.63,both P＜0.05],while there was no significant difference in the prevalence of AD in the first-degree relatives between mania patients and control group [1.1％ (1/87) vs.4.4％ (12/274),x2 =1.99,P＞0.05].Conclusions There is a high risk for Alzheimer' s disease in first-degree relatives of patients with affective disorders,particularly in first-degree relatives of patients with depression and bipolar disorders.