中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
11期
1152-1154
,共3页
高血压%脂联素%利钠肽,脑%肥大,左心空
高血壓%脂聯素%利鈉肽,腦%肥大,左心空
고혈압%지련소%리납태,뇌%비대,좌심공
Hypertension%Adiponectin%Natriuretic peptide,brain%Hypertrophy,left ventricular
目的 探讨高血压病患者血浆脂联素(APN)、脑钠肽(BNP)与左心室肥厚的关系及其形成的可能机理. 方法 泰州市人民医院心内科住院的患者120例,高血压80例,其中伴左心室肥厚者40例(左心室肥厚组),单纯高血压者40例(高血压组),另选40例年龄、性别、体质量与其匹配的健康者为对照组.入选患者均排除继发性高血压且无心、脑、肾功能障碍及糖尿病.酶联免疫吸附法(ELISA)法检测血浆APN和BNP水平.心脏超声检测患者左心室舒张末期内径(LVEDD)、舒张末期左心室后壁厚度(LVPWT)、舒张末期室间隔厚度(IVST).根据公式计算左心室质量(LVM)及左心室质量指数(LVMI). 结果 高血压组、左心室肥厚组APN、BNP、LVMI分别为(7.9±0.3)mg/L(116.1±16.1) μg/L、(104.0±9.6) g/m2与(6.7±0.1) mg/L、(182.4±18.5) μg/L、(153.7±21.0)g/m2,与对照组(12.0±0.2) mg/L、(69.1±8.9)μg/L、(83.1±9.1)g/m2比较,差异有统计学意义(均P＜0.01);左心室肥厚组与高血压组比较差异有统计学意义(均P＜0.01).血清APN水平与高血压左心室肥厚程度负相关(r=-o.789,P＜0.01),BNP水平与左心室肥厚程度正相关(r=0.811,P＜0.05). 结论 血清APN、BNP水平与高血压及高血压左心室肥厚有相关性.
目的 探討高血壓病患者血漿脂聯素(APN)、腦鈉肽(BNP)與左心室肥厚的關繫及其形成的可能機理. 方法 泰州市人民醫院心內科住院的患者120例,高血壓80例,其中伴左心室肥厚者40例(左心室肥厚組),單純高血壓者40例(高血壓組),另選40例年齡、性彆、體質量與其匹配的健康者為對照組.入選患者均排除繼髮性高血壓且無心、腦、腎功能障礙及糖尿病.酶聯免疫吸附法(ELISA)法檢測血漿APN和BNP水平.心髒超聲檢測患者左心室舒張末期內徑(LVEDD)、舒張末期左心室後壁厚度(LVPWT)、舒張末期室間隔厚度(IVST).根據公式計算左心室質量(LVM)及左心室質量指數(LVMI). 結果 高血壓組、左心室肥厚組APN、BNP、LVMI分彆為(7.9±0.3)mg/L(116.1±16.1) μg/L、(104.0±9.6) g/m2與(6.7±0.1) mg/L、(182.4±18.5) μg/L、(153.7±21.0)g/m2,與對照組(12.0±0.2) mg/L、(69.1±8.9)μg/L、(83.1±9.1)g/m2比較,差異有統計學意義(均P＜0.01);左心室肥厚組與高血壓組比較差異有統計學意義(均P＜0.01).血清APN水平與高血壓左心室肥厚程度負相關(r=-o.789,P＜0.01),BNP水平與左心室肥厚程度正相關(r=0.811,P＜0.05). 結論 血清APN、BNP水平與高血壓及高血壓左心室肥厚有相關性.
목적 탐토고혈압병환자혈장지련소(APN)、뇌납태(BNP)여좌심실비후적관계급기형성적가능궤리. 방법 태주시인민의원심내과주원적환자120례,고혈압80례,기중반좌심실비후자40례(좌심실비후조),단순고혈압자40례(고혈압조),령선40례년령、성별、체질량여기필배적건강자위대조조.입선환자균배제계발성고혈압차무심、뇌、신공능장애급당뇨병.매련면역흡부법(ELISA)법검측혈장APN화BNP수평.심장초성검측환자좌심실서장말기내경(LVEDD)、서장말기좌심실후벽후도(LVPWT)、서장말기실간격후도(IVST).근거공식계산좌심실질량(LVM)급좌심실질량지수(LVMI). 결과 고혈압조、좌심실비후조APN、BNP、LVMI분별위(7.9±0.3)mg/L(116.1±16.1) μg/L、(104.0±9.6) g/m2여(6.7±0.1) mg/L、(182.4±18.5) μg/L、(153.7±21.0)g/m2,여대조조(12.0±0.2) mg/L、(69.1±8.9)μg/L、(83.1±9.1)g/m2비교,차이유통계학의의(균P＜0.01);좌심실비후조여고혈압조비교차이유통계학의의(균P＜0.01).혈청APN수평여고혈압좌심실비후정도부상관(r=-o.789,P＜0.01),BNP수평여좌심실비후정도정상관(r=0.811,P＜0.05). 결론 혈청APN、BNP수평여고혈압급고혈압좌심실비후유상관성.
Objective To study the correlation of serum adiponectin (ANP) and brain natriuretic peptide (BNP) levels with left ventricular hypertrophy in essential hypertension patients,and to investigate its potential mechanism.Methods 80 patients with essential hypertension in our hospital were recruited.Secondary hypertension,cardiac,brain and renal insufficiency and diabetes mellitus were excluded in the study patients.Patients were divided into 2 groups:left ventricular hypertrophy group (LVH group,n=40) and hypertension group (hypertension patients without left ventricular hypertrophy,n=40).Age-,sex-,body mass matched health subjects were selected as control group (n =40).Serum levels of ANP and BNP were determined by enzyme-linked immunosorbent assay (ELISA).Left ventricular end diastolic dimension (LVEDD),left ventricular posterior wall thickness (LVPWT) and interventricular septum thickness (IVST) were detected by ultrasonic cardiography.Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated according to formula of Devereux.Results There were significant differences in serum levels of APN and BNP and LVMI between hypertension,LVH and control groups [(7.9±0.3) mg/L,(6.7±0.1)mg/L vs.(12.0±0.2)mg/L,(116.1±16.1)μg/Lvs.(182.4±18.5)μg/L,(104.0± ±9.6)g/m2,(153.7±21.0)g/m2 vs.(83.1±9.1)g/m2,respectively,all P＜0.01].Serum APN level was negatively correlated with the severity of LVH (r=-0.789,P＜0.01),while serum BNP level was positively correlated with the severity of LVH (r=0.811,P＜ 0.05).Conclusions Serum APN and BNP levels have correlation with hypertension and hypertension related LVH.
