中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
11期
1155-1158
,共4页
李侠%郭燕%胡有东%陈颖%郭殿选%周华兰%杨海晨%李霞
李俠%郭燕%鬍有東%陳穎%郭殿選%週華蘭%楊海晨%李霞
리협%곽연%호유동%진영%곽전선%주화란%양해신%리하
心肌梗死%肌细胞,心脏%血管成形术,经腔,经皮冠状动脉
心肌梗死%肌細胞,心髒%血管成形術,經腔,經皮冠狀動脈
심기경사%기세포,심장%혈관성형술,경강,경피관상동맥
Myocardial infarction%Myocytes,cardiac%Angioplasty,transluminal,percutaneous coronary
目的 探讨CD133+、CD14+CD16+和CD42b表达水平与老年陈旧性心肌梗死患者心肌细胞成形术早期预后的相关性. 方法 采用流式细胞仪检测经皮冠状动脉介入治疗(PCI)+支架植入术患者和PCI+支架植入术+人脐带造血干细胞(hUCM)移植术患者循环CD133+、CD14+CD16+和CD42b的表达水平与心肌梗死面积和左心室射血分数(LVEF)的关系.评估CD133+、CD14+CD16+和CD42b对细胞心肌成形术早期预后的影响. 结果 PCI+支架植入术后8周CD133+(0.05±0.02)％、CD14+CD16+(0.9±0.2)％、CD42b(70.6±1.3)％,PCI+支架植入术+hUCB移植后8周CD133+ (0.07±0.01)％、CD14+ CD16+ (0.6±0.3)％、CD42b(80.2±8.3)％,两组比较,差异有统计学意义(P＜0.01). 结论 CD133+、CD14+CD16+和CD42b表达水平可能预测老年陈旧性心肌梗死患者心肌细胞成形术的早期预后.
目的 探討CD133+、CD14+CD16+和CD42b錶達水平與老年陳舊性心肌梗死患者心肌細胞成形術早期預後的相關性. 方法 採用流式細胞儀檢測經皮冠狀動脈介入治療(PCI)+支架植入術患者和PCI+支架植入術+人臍帶造血榦細胞(hUCM)移植術患者循環CD133+、CD14+CD16+和CD42b的錶達水平與心肌梗死麵積和左心室射血分數(LVEF)的關繫.評估CD133+、CD14+CD16+和CD42b對細胞心肌成形術早期預後的影響. 結果 PCI+支架植入術後8週CD133+(0.05±0.02)％、CD14+CD16+(0.9±0.2)％、CD42b(70.6±1.3)％,PCI+支架植入術+hUCB移植後8週CD133+ (0.07±0.01)％、CD14+ CD16+ (0.6±0.3)％、CD42b(80.2±8.3)％,兩組比較,差異有統計學意義(P＜0.01). 結論 CD133+、CD14+CD16+和CD42b錶達水平可能預測老年陳舊性心肌梗死患者心肌細胞成形術的早期預後.
목적 탐토CD133+、CD14+CD16+화CD42b표체수평여노년진구성심기경사환자심기세포성형술조기예후적상관성. 방법 채용류식세포의검측경피관상동맥개입치료(PCI)+지가식입술환자화PCI+지가식입술+인제대조혈간세포(hUCM)이식술환자순배CD133+、CD14+CD16+화CD42b적표체수평여심기경사면적화좌심실사혈분수(LVEF)적관계.평고CD133+、CD14+CD16+화CD42b대세포심기성형술조기예후적영향. 결과 PCI+지가식입술후8주CD133+(0.05±0.02)％、CD14+CD16+(0.9±0.2)％、CD42b(70.6±1.3)％,PCI+지가식입술+hUCB이식후8주CD133+ (0.07±0.01)％、CD14+ CD16+ (0.6±0.3)％、CD42b(80.2±8.3)％,량조비교,차이유통계학의의(P＜0.01). 결론 CD133+、CD14+CD16+화CD42b표체수평가능예측노년진구성심기경사환자심기세포성형술적조기예후.
Objective To study the relationship between expression of peripheral blood CD133 +,CD14+CD16 +,CD42b and early prognosis of cellular cardiomyoplasty in elderly patients with old myocardial infarction.Methods The expressions of circulating CD133+,CD14+CD16+,CD42b in elderly patients with coronary stent implantation and cellular cardiomyoplasty were measured by flow cytometry to observe the effects of levels in CD133+,CD14 +CD16+ and CD42b on infarct size and left ventricular ejection fraction (LVEF).Results At eight weeks,there were significant difference in molecular markers between cellular cardiomyoplasty and coronary stent implantation:CD133 +(0.07±0.01)％,CD14+CD16+(0.6±0.3)％,CD42b(80.2±8.3)％ vs.CD133+(0.05±0.02)％,CD14+CD16+(0.9±0.2)％,CD42b(70.6±1.3) ％,all P＜0.01.Conclusions The changes of CD133+,CD14+CD16 +,CD42b may predict early prognosis of cellular cardiomyoplasty in elderly patients with old myocardial infarction.
