CAJ | 학술논문

目的观察代谢综合征(MS)及其各组分与血尿酸水平的关系. 方法 2000年7月至9月在北京宣武、怀柔、大兴3个地区通过分层、整群、随机的抽样方法抽取1821例老年人进行问卷调查、体格检查及血生化检测,分析MS及其各组分与血尿酸水平的关系. 结果 1821例老年人中,MS者365例(20.0％),非MS者1456例(80.0％),MS组老年人血尿酸水平(5.20±2.27)μmol/L,明显高于非MS组(4.50±1.44)μmol/L(t=-7.34,P=0.000).通过四分位法依据血尿酸水平将老年人分为4组,血尿酸≤3.5 μmol/L443例、3.6 μmol/L≤血尿酸≤4.4 μmol/L 465例、4.5μmol/L≤血尿酸≤5.4 μmol/L 446例、血尿酸≥5.5 μmol/L 467例,随着血尿酸水平的升高,体质指数(BMD)、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)均逐渐升高,高密度脂蛋白胆固醇(HDL-C)逐渐降低(F=43.07、9.32、22.36、8.19、9.39,均P＜0.01);MS组分数目在不同血尿酸水平组人群中分布差异具有统计学意义(x2=73.62,P=0.000).控制了年龄、性别、居住地区、文化程度、婚姻状况、吸烟、饮酒和体育锻炼因素的影响后,logistic回归分析结果显示,MS患病与血尿酸水平有关,随着血尿酸水平的增高,MS患病风险明显增加(均P＜0.01). 结论 MS患病与血尿酸水平有关,应注意观察并控制患MS老年人的血尿酸水平.
목적 관찰대사종합정(MS)급기각조분여혈뇨산수평적관계. 방법 2000년7월지9월재북경선무、부유、대흥3개지구통과분층、정군、수궤적추양방법추취1821례노년인진행문권조사、체격검사급혈생화검측,분석MS급기각조분여혈뇨산수평적관계. 결과 1821례노년인중,MS자365례(20.0％),비MS자1456례(80.0％),MS조노년인혈뇨산수평(5.20±2.27)μmol/L,명현고우비MS조(4.50±1.44)μmol/L(t=-7.34,P=0.000).통과사분위법의거혈뇨산수평장노년인분위4조,혈뇨산≤3.5 μmol/L443례、3.6 μmol/L≤혈뇨산≤4.4 μmol/L 465례、4.5μmol/L≤혈뇨산≤5.4 μmol/L 446례、혈뇨산≥5.5 μmol/L 467례,수착혈뇨산수평적승고,체질지수(BMD)、혈청총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)균축점승고,고밀도지단백담고순(HDL-C)축점강저(F=43.07、9.32、22.36、8.19、9.39,균P＜0.01);MS조분수목재불동혈뇨산수평조인군중분포차이구유통계학의의(x2=73.62,P=0.000).공제료년령、성별、거주지구、문화정도、혼인상황、흡연、음주화체육단련인소적영향후,logistic회귀분석결과현시,MS환병여혈뇨산수평유관,수착혈뇨산수평적증고,MS환병풍험명현증가(균P＜0.01). 결론 MS환병여혈뇨산수평유관,응주의관찰병공제환MS노년인적혈뇨산수평.
Objective To investigate the relationship between serum uric acid (SUA) and metabolism syndrome (MS) in community-based elderly population in Beijing.Methods A community-based and cross-sectional survey on 1821 elderly person was performed in Beijing in 2000.Questionnaire survey,physical examination and blood biochemical tests were conducted.Relationship of MS and its components with SUA was analyzed.Results Among 1821 subjects,there were 365 cases with MS (20.0％) and 1456 cases without MS (80.0％).SUA level was higher in MS group than in non-MS group [(5.20±2.27) μmol/L vs.(4.50±1.44) μmol/L,t=-7.34,P=0.000].All subjects were divided into 4 groups according SUA level:goup 1 (≤3.5μmol/L,n=443),group 2 (3.6 μmol/L-4.4 μmol/L,n=465),group 3 (4.5 μmol/L-5.4 μmol/L,n=446) and group 4 (≥5.5 μmol/L,n=467).SUA level was increased along with the increased BMI,TG,TC,LDL-C levels,and decreased along with the decreased HDL-C level,which had significant differences (F=43.07,9.32,22.36,8.19,9.39,all P＜0.001).There were significant distribution differences in MS components numbers in the 4 groups (x2=73.62,P=0.000).After adjusting for age,sex,residential,education level,marriage,smoking,drinking and exercise habits,logistic regression analysis showed that MS was related with SUA level,and the risk of MS was increased along with the increased SUA level.Conclusions MS is correlated with SUA level in elderly people.SUA level should be observed and controlled effectively in the elderly.