CAJ | 학술논문

目的评价中国人群糖尿病肾病与亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性的相关性. 方法根据系统评估的原理和规范,检索外文专业期刊数据库(PubMed、Medline、EMBASE)及中文期刊数据库,分别基于隐性遗传模型和显性遗传模型,meta分析评估MTHFR基因C677T位点风险等位基因T与中国人群糖尿病肾病的相关性.异质性检验后采用M-H固定效应模型合并比值比(OR)值,采用Begg和Egger偏倚分析评估本项meta分析的发表偏倚. 结果共纳入10篇文献,包含共计2018例人群数据结果.异质性检验表明不存在异质性,选择M-H固定效应模型进行数据合并,隐性模型合并后的OR为2.41(95％CI=1.85～3.13),显性模型合并后的OR为2.33(95％CI=1.82～2.98).Begg和Egger偏倚分析显示隐性和显性遗传模型下都无明显发表偏倚. 结论 MTHFR基因C677T位点风险等位基因T与中国人群糖尿病肾病的发生风险正相关.
목적 평개중국인군당뇨병신병여아갑기사경협산환원매(MTHFR)기인C677T다태성적상관성. 방법 근거계통평고적원리화규범,검색외문전업기간수거고(PubMed、Medline、EMBASE)급중문기간수거고,분별기우은성유전모형화현성유전모형,meta분석평고MTHFR기인C677T위점풍험등위기인T여중국인군당뇨병신병적상관성.이질성검험후채용M-H고정효응모형합병비치비(OR)치,채용Begg화Egger편의분석평고본항meta분석적발표편의. 결과 공납입10편문헌,포함공계2018례인군수거결과.이질성검험표명불존재이질성,선택M-H고정효응모형진행수거합병,은성모형합병후적OR위2.41(95％CI=1.85～3.13),현성모형합병후적OR위2.33(95％CI=1.82～2.98).Begg화Egger편의분석현시은성화현성유전모형하도무명현발표편의. 결론 MTHFR기인C677T위점풍험등위기인T여중국인군당뇨병신병적발생풍험정상관.
Objective To evaluate the association between methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism and diabetic kidney disease in Chinese population.Methods After searching the related literatures from PubMed,Medline,EMBASE databases and common Chinese journal literature databases,meta-analysis was performed to assess the association of MTHFR C677T polymorphism with diabetic kidney disease according to the principles of systematic review based on the recessive model and dominant model respectively.Fixed effect model (M-H) was used to pool odd ratio (OR) after heterogeneity test.The Begg and Egger analysis were conducted to evaluate the publication bias.Results 10 literatures including a total of 2018 cases were included in the metaanalysis.No significant heterogeneity was detected.Data were pooled by fixed effect model.The total OR was 2.41 (95％CI=1.85～3.13) and 2.33 (95％CI=1.82～2.98) in recessive and dominant models respectively.No obvious publication bias was observed by Begg and Egger analysis.Conclusions The T allele of C677T polymorphism in MTHFR gene is positively associated with diabetic kidney disease in Chinese population.