CAJ | 학술논문

目的研究三酰甘油与高密度脂蛋白胆固醇比值(TG/HDL-C)与冠心病的发病及其冠状动脉(冠脉)狭窄程度的关系. 方法 158例冠心病患者根据选择性冠脉造影证实将其分为对照组和冠脉狭窄组(狭窄组),狭窄组分为单支病变组,双支病变组和多支病变组.评估危险因素与冠脉病变支数的关系,Gensini评分评价冠脉病变狭窄程度. 结果狭窄组患者较对照组TG/HDL-C比值升高,分别为1.8±1.0、1.7±1.4(t＝2.68,P＜0.05);随着冠脉病变程度的加重,TG/HDL-C比值呈逐渐升高趋势,多支病变组患者TG/HDL-C比值升高(P＜0.05).多支冠脉病变与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、TG/HDL C呈正相关(β值分别为0.326、0.339、0.158,均P＜0.05). 结论 TG/HDL-C比值与多支冠脉病变相关.但该比值的临床意义较其他指标无更强的相关性.
목적 연구삼선감유여고밀도지단백담고순비치(TG/HDL-C)여관심병적발병급기관상동맥(관맥)협착정도적관계. 방법 158례관심병환자근거선택성관맥조영증실장기분위대조조화관맥협착조(협착조),협착조분위단지병변조,쌍지병변조화다지병변조.평고위험인소여관맥병변지수적관계,Gensini평분평개관맥병변협착정도. 결과 협착조환자교대조조TG/HDL-C비치승고,분별위1.8±1.0、1.7±1.4(t＝2.68,P＜0.05);수착관맥병변정도적가중,TG/HDL-C비치정축점승고추세,다지병변조환자TG/HDL-C비치승고(P＜0.05).다지관맥병변여총담고순(TC)、저밀도지단백담고순(LDL-C)、TG/HDL C정정상관(β치분별위0.326、0.339、0.158,균P＜0.05). 결론 TG/HDL-C비치여다지관맥병변상관.단해비치적림상의의교기타지표무경강적상관성.
Objective To investigate the relationship of triglycerides/high-density lipoprotein (TG/HDL C) ratio with coronary heart disease (CHD) and its severity.Methods 158 patients with CHD were enrolled in this study.Patients were divided into 4 groups according to the selective coronary arteriography:the control group,single-vessel CHD group,double-vessel CHD group,multiple-vessel CHD group.The relationship between multiple risk factors and CHD was analyzed by stepwise multiple regression.The severity of coronary artery stenosis was analyzed by Gensini scoring system.Results TG/HDL-C ratio was elevated in patients with coronary artery stenosis as compared with the control group [(1.8±1.0) vs.(1.7±1.4),t=2.68,P＜0.05].TG/HDL-C ratio was elevated along with the severity of CHD.TG/HDL-C ratio was elevated in multiple-vessel C HD group as compared with the control group by ANOVA analysis (P＜0.05).Stepwise multiple regression showed that multiple-vessel CHD was positive related with total cholesterol (TC),LDL-C and TG/HDL-C ratio (β value:0.326,0.339,0.158,respectively,all P＜0.05).Conclusions TG/HDL C ratio is related with multiple vessel CHD,but it does not have more clinical significances than other indicators.