中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
1期
18-22
,共5页
冠心病%白细胞介素-1%多态现象,遗传学
冠心病%白細胞介素-1%多態現象,遺傳學
관심병%백세포개소-1%다태현상,유전학
Coronary heart disease%Interleukin-1%Polymorphism,genetics
目的 探讨白细胞介素-1(IL-1)家族(IL-1α、IL-1β)和白细胞介素-1受体拮抗剂(IL-1Ra)基因型与老年人冠心病风险及血脂水平的相关性. 方法 应用聚合酶链反应和限制性片段长度多态性的方法检测了329例老年冠心病患者和318例老年对照者IL-1家族基因型,同时检测了血脂水平. 结果 老年冠心病组IL-1Ra“TT”和IL-1Ra“Ⅰ/Ⅰ与Ⅰ/Ⅳ”基因型频率为90.3％,而对照组基因型频率均为82.4％,与对照组比较,IL-1Ra“TT、Ⅰ/Ⅰ或Ⅰ/Ⅳ”基因型携带者,其患老年冠心病的风险是IL-1Ra“CC或TC”和IL-1Ra“Ⅰ/Ⅱ或Ⅱ/Ⅱ”基因型的1.98倍(x2=8.55,95％CI:1.25～3.16);在老年冠心病人群中,急性冠状动脉综合征组IL-1Ra“TT”和IL-1Ra“Ⅰ/Ⅰ与Ⅰ/Ⅳ”基因型频率为96.2％,而稳定型心绞痛组基因型频率均为84.8％,与稳定型心绞痛组比较,其患急性冠状动脉综合征的风险为4.54倍(x2=12.17,95％CI:1.81～11.36);急性冠状动脉综合征组IL-1α-889“CT或TT”基因型频率为22.8％,而稳定型心绞痛组基因型频率为7.6％,IL-1(-889)“CT或TT”基因型携带者,其患急性冠状动脉综合征的风险约是IL-1α (-889)“CC”基因型的3.59倍(x2=14.93,95％CI:1.82～7.03);各组基因型间血脂水平的比较差异无统计学意义(P＞0.05). 结论 在老年冠心病人群中,IL-1α (-889)“CT或TT”基因型携带者患急性冠状动脉综合征的风险较高,而IL-1Ra“CC、TC、Ⅰ/Ⅱ或Ⅱ/Ⅱ”基因型携带者患老年冠心病或患严重老年冠心病的风险较低.
目的 探討白細胞介素-1(IL-1)傢族(IL-1α、IL-1β)和白細胞介素-1受體拮抗劑(IL-1Ra)基因型與老年人冠心病風險及血脂水平的相關性. 方法 應用聚閤酶鏈反應和限製性片段長度多態性的方法檢測瞭329例老年冠心病患者和318例老年對照者IL-1傢族基因型,同時檢測瞭血脂水平. 結果 老年冠心病組IL-1Ra“TT”和IL-1Ra“Ⅰ/Ⅰ與Ⅰ/Ⅳ”基因型頻率為90.3％,而對照組基因型頻率均為82.4％,與對照組比較,IL-1Ra“TT、Ⅰ/Ⅰ或Ⅰ/Ⅳ”基因型攜帶者,其患老年冠心病的風險是IL-1Ra“CC或TC”和IL-1Ra“Ⅰ/Ⅱ或Ⅱ/Ⅱ”基因型的1.98倍(x2=8.55,95％CI:1.25～3.16);在老年冠心病人群中,急性冠狀動脈綜閤徵組IL-1Ra“TT”和IL-1Ra“Ⅰ/Ⅰ與Ⅰ/Ⅳ”基因型頻率為96.2％,而穩定型心絞痛組基因型頻率均為84.8％,與穩定型心絞痛組比較,其患急性冠狀動脈綜閤徵的風險為4.54倍(x2=12.17,95％CI:1.81～11.36);急性冠狀動脈綜閤徵組IL-1α-889“CT或TT”基因型頻率為22.8％,而穩定型心絞痛組基因型頻率為7.6％,IL-1(-889)“CT或TT”基因型攜帶者,其患急性冠狀動脈綜閤徵的風險約是IL-1α (-889)“CC”基因型的3.59倍(x2=14.93,95％CI:1.82～7.03);各組基因型間血脂水平的比較差異無統計學意義(P＞0.05). 結論 在老年冠心病人群中,IL-1α (-889)“CT或TT”基因型攜帶者患急性冠狀動脈綜閤徵的風險較高,而IL-1Ra“CC、TC、Ⅰ/Ⅱ或Ⅱ/Ⅱ”基因型攜帶者患老年冠心病或患嚴重老年冠心病的風險較低.
목적 탐토백세포개소-1(IL-1)가족(IL-1α、IL-1β)화백세포개소-1수체길항제(IL-1Ra)기인형여노년인관심병풍험급혈지수평적상관성. 방법 응용취합매련반응화한제성편단장도다태성적방법검측료329례노년관심병환자화318례노년대조자IL-1가족기인형,동시검측료혈지수평. 결과 노년관심병조IL-1Ra“TT”화IL-1Ra“Ⅰ/Ⅰ여Ⅰ/Ⅳ”기인형빈솔위90.3％,이대조조기인형빈솔균위82.4％,여대조조비교,IL-1Ra“TT、Ⅰ/Ⅰ혹Ⅰ/Ⅳ”기인형휴대자,기환노년관심병적풍험시IL-1Ra“CC혹TC”화IL-1Ra“Ⅰ/Ⅱ혹Ⅱ/Ⅱ”기인형적1.98배(x2=8.55,95％CI:1.25～3.16);재노년관심병인군중,급성관상동맥종합정조IL-1Ra“TT”화IL-1Ra“Ⅰ/Ⅰ여Ⅰ/Ⅳ”기인형빈솔위96.2％,이은정형심교통조기인형빈솔균위84.8％,여은정형심교통조비교,기환급성관상동맥종합정적풍험위4.54배(x2=12.17,95％CI:1.81～11.36);급성관상동맥종합정조IL-1α-889“CT혹TT”기인형빈솔위22.8％,이은정형심교통조기인형빈솔위7.6％,IL-1(-889)“CT혹TT”기인형휴대자,기환급성관상동맥종합정적풍험약시IL-1α (-889)“CC”기인형적3.59배(x2=14.93,95％CI:1.82～7.03);각조기인형간혈지수평적비교차이무통계학의의(P＞0.05). 결론 재노년관심병인군중,IL-1α (-889)“CT혹TT”기인형휴대자환급성관상동맥종합정적풍험교고,이IL-1Ra“CC、TC、Ⅰ/Ⅱ혹Ⅱ/Ⅱ”기인형휴대자환노년관심병혹환엄중노년관심병적풍험교저.
Objective To investigate the correlation of interleukin-1 family genotypes,including interleukin-1 (IL-1α,IL-1β) and interleukin-1 receptor antagonist (IL-1Ra),with coronary heart disease (CHD) and serum lipoprotein level in the elderly.Methods Interleukin-1 family genotypes were detected in 318 elderly controls and 329 elderly CHD patients by polymerase chain reaction and restriction fragment length polymorphisms method.Serum levels of lipoproteins were inspected simultaneously.Results The TT and Ⅰ / Ⅰ or Ⅰ/Ⅳ genotype frequency of IL-1Ra was 90.3％ in elderly CHD patients,but 82.4％ in controls.Carriers with TT,Ⅰ / Ⅰ or Ⅰ/Ⅳ genotype of IL-1Ra were at an increased risk with an odds ratio of 1.98 in elderly CHD patients as compared with controls (x2=8.55,95％ CI:1.25-3.16).The TT and Ⅰ/Ⅰ or Ⅰ/Ⅳ genotype frequency of IL-1Ra was 96.2％ in elderly CHD patients with acute coronary syndrome,but 84.8％ in elderly CHD patients with stable angina.Carriers with TT,Ⅰ / Ⅰ or Ⅰ/Ⅳ genotype of IL-1Ra were at an increased risk with an odds ratio of 4.54 in acute coronary syndrome group as compared with stable angina group (x2=12.17,95％CI:1.81-11.36).The CT or TT genotype frequency of IL-1α-889 was 22.8％ in acute coronary syndrome group,but 7.6 ％ in stable angina group.Carriers with CT or TT genotype of IL-1α-889 were at an increased risk with an odds ratio of 3.59 as compared with stable angina group (x2 =14.93,95％CI:1.82-7.03).There were no significant differences in levels of serum lipoproteins among the different genotypes (P＞0.05).Conclusions In elderly patients with coronary heart disease,IL-1α(-889) CT or TT genotype carriers are at high risk for acute coronary syndrome,but IL-1Ra CC,TC,Ⅰ / Ⅱ or Ⅱ / Ⅱ genotype carriers are at a low risk for CHD or severe CHD.
