CAJ | 학술논문

目的探讨血清25羟维生素D[25(OH)D3]与前列腺增生发生、发展的相关性. 方法纳入北京大学人民医院老年科住院老年男性患者95例.测量血压、身高、体质量,计算体质指数(BMI),并检测血脂、空腹血糖(FPG)、血钙、前列腺特异性抗原(PSA)等指标,采用酶免疫分析法测定血清25(OH)D3水平.超声测量并计算前列腺体积(PV)及PV年增长率. 结果 95例老年男性血清25(OH)D3水平为12.1～83.9 nmol/L,平均(35.5±15.2) nmol/L.血清25 (OH) D3＞50nmol/L组老年男性患者PV低于25(OH)D3≤50 nmol/L组[(31.5±6.0)ml与(39.9±14.5)ml,P＜0.001];PV年增长率也低于25(OH)D3≤50 nmol/L组[(0.4±0.2)ml/年与(0.5±0.4)ml/年,P＜0.01].相关分析结果显示,PV与血清25(OH)D3呈负相关(r=-0.207,P=0.044),与BMI、PSA呈正相关(r值分别为0.297、0.958,P=0.011和P＜0.001);PV年增长率也与BMI、PSA呈正相关(r值分别为0.316、0.464,P=0.007和P＜0.001),与血清25(OH)D3呈负相关,但差异无统计学意义(P＞0.05). 结论低水平血清25(OH)D3可能是前列腺增生的危险因素.
목적 탐토혈청25간유생소D[25(OH)D3]여전렬선증생발생、발전적상관성. 방법 납입북경대학인민의원노년과주원노년남성환자95례.측량혈압、신고、체질량,계산체질지수(BMI),병검측혈지、공복혈당(FPG)、혈개、전렬선특이성항원(PSA)등지표,채용매면역분석법측정혈청25(OH)D3수평.초성측량병계산전렬선체적(PV)급PV년증장솔. 결과 95례노년남성혈청25(OH)D3수평위12.1～83.9 nmol/L,평균(35.5±15.2) nmol/L.혈청25 (OH) D3＞50nmol/L조노년남성환자PV저우25(OH)D3≤50 nmol/L조[(31.5±6.0)ml여(39.9±14.5)ml,P＜0.001];PV년증장솔야저우25(OH)D3≤50 nmol/L조[(0.4±0.2)ml/년여(0.5±0.4)ml/년,P＜0.01].상관분석결과현시,PV여혈청25(OH)D3정부상관(r=-0.207,P=0.044),여BMI、PSA정정상관(r치분별위0.297、0.958,P=0.011화P＜0.001);PV년증장솔야여BMI、PSA정정상관(r치분별위0.316、0.464,P=0.007화P＜0.001),여혈청25(OH)D3정부상관,단차이무통계학의의(P＞0.05). 결론 저수평혈청25(OH)D3가능시전렬선증생적위험인소.
Objective To explore the relationship between serum 25-hydroxy vitamin D level and prostatic hyperplasia in elderly men.Methods Totally 95 male patients aged over 60 years were included.Blood pressure,body weight,body height,body mass index (BMI) were measured and calculated.Venous blood samples were obtained to determine fasting serum levels of 25-hydroxy vitamin D3 and blood glucose (FBG),total cholesterol (TC),triglycerides (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),calcium and prostate specific antigen (PSA),total prostate volume(PV) and annual prostate growth rate were measured and calculated by ultrasound.Results The serum 25 (OH) D3 levels were varied from 12.1 nmol/L to 83.9 nmol/L,with an average of (35.5±15.2) nmol/L in elderly male patients.PV growth rate were significantly lower in elderly men with 25 (OH) D3 ＞ 50 nmol/L than in elderly men with 25 (OH) D3≤50nmol/L[(31.5± 6.0) mlvs.(39.9 ± 14.5) ml,(0.4± 0.2) ml/yvs.(0.5 ± 0.4) ml/y,P＜0.001 or 0.01].PV was negatively correlated with serum 25-hydroxy vitamin D3 level (r=-0.207,P＜0.05),and positively correlated with BMI and PSA (r=0.297,0.958,P＜0.05 or and P＜0.001).While annual prostate growth rate was positively correlated with BMI and PSA (r=0.316,0.464,P＜0.01 or ＜0.001),and positively correlated with serum 25-hydroxy vitamin D3 level,but the difference was not statistically significant (P＞0.05).Conclusions Low serum 25-hydroxy vitamin D3 level may play a role in the pathogenesis of prostatic hyperplasia.