中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2008年
8期
783-786
,共4页
钱燕华%林玉娣%沈洪兵%董美华%邓于%缪小兰%王旭雯%顾静%陈峰%喻荣彬
錢燕華%林玉娣%瀋洪兵%董美華%鄧于%繆小蘭%王旭雯%顧靜%陳峰%喻榮彬
전연화%림옥제%침홍병%동미화%산우%무소란%왕욱문%고정%진봉%유영빈
乙型肝炎病毒%自然人群%免疫状况
乙型肝炎病毒%自然人群%免疫狀況
을형간염병독%자연인군%면역상황
Hepatitis B virus%Natural population%Immunity
目的 对江苏省无锡市城区20岁以上自然人群HBV感染与乙型肝炎(乙肝)疫苗接种关系进行研究.方法 按知情、自愿、随机的原则抽取无锡市20岁以上的自然人群3744名进行乙肝血清流行率和乙肝疫苗接种调查,采用ELISA和放射免疫分析法测定乙肝五项指标(HBsAg、抗-HBS、HBeAg、抗-HBe和抗-HBc).结果 3744名调查对象总HBV感染率经标化后为51.7%,HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc阳性率经标化后分别为4.5%、48.5%、0.3%、3.5%、51.4%.30岁以下人群HBsAg阳性率最低,分别为2.9%和2.6%.抗-HBc阳性率男性显著高于女性(P<0.05),且随着年龄的增加而逐步升高(趋势χ2=256.2,P<0.001).该人群乙肝疫苗标化接种率为17.6%,随着年龄的增加接种率迅速下降(P<0.05).接种疫苗人群的HBsAg阳性率和HBV感染率明显低于未接种疫苗人群、抗-HBs阳性率则高于未接种人群(P值均<0.05).结论 成年人接种乙肝疫苗可以影响整个人群的HBV感染模式,在加强新生儿乙肝疫苗计划免疫同时,应进一步加强对成年人的乙肝疫苗免疫策略.
目的 對江囌省無錫市城區20歲以上自然人群HBV感染與乙型肝炎(乙肝)疫苗接種關繫進行研究.方法 按知情、自願、隨機的原則抽取無錫市20歲以上的自然人群3744名進行乙肝血清流行率和乙肝疫苗接種調查,採用ELISA和放射免疫分析法測定乙肝五項指標(HBsAg、抗-HBS、HBeAg、抗-HBe和抗-HBc).結果 3744名調查對象總HBV感染率經標化後為51.7%,HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc暘性率經標化後分彆為4.5%、48.5%、0.3%、3.5%、51.4%.30歲以下人群HBsAg暘性率最低,分彆為2.9%和2.6%.抗-HBc暘性率男性顯著高于女性(P<0.05),且隨著年齡的增加而逐步升高(趨勢χ2=256.2,P<0.001).該人群乙肝疫苗標化接種率為17.6%,隨著年齡的增加接種率迅速下降(P<0.05).接種疫苗人群的HBsAg暘性率和HBV感染率明顯低于未接種疫苗人群、抗-HBs暘性率則高于未接種人群(P值均<0.05).結論 成年人接種乙肝疫苗可以影響整箇人群的HBV感染模式,在加彊新生兒乙肝疫苗計劃免疫同時,應進一步加彊對成年人的乙肝疫苗免疫策略.
목적 대강소성무석시성구20세이상자연인군HBV감염여을형간염(을간)역묘접충관계진행연구.방법 안지정、자원、수궤적원칙추취무석시20세이상적자연인군3744명진행을간혈청류행솔화을간역묘접충조사,채용ELISA화방사면역분석법측정을간오항지표(HBsAg、항-HBS、HBeAg、항-HBe화항-HBc).결과 3744명조사대상총HBV감염솔경표화후위51.7%,HBsAg、항-HBs、HBeAg、항-HBe、항-HBc양성솔경표화후분별위4.5%、48.5%、0.3%、3.5%、51.4%.30세이하인군HBsAg양성솔최저,분별위2.9%화2.6%.항-HBc양성솔남성현저고우녀성(P<0.05),차수착년령적증가이축보승고(추세χ2=256.2,P<0.001).해인군을간역묘표화접충솔위17.6%,수착년령적증가접충솔신속하강(P<0.05).접충역묘인군적HBsAg양성솔화HBV감염솔명현저우미접충역묘인군、항-HBs양성솔칙고우미접충인군(P치균<0.05).결론 성년인접충을간역묘가이영향정개인군적HBV감염모식,재가강신생인을간역묘계화면역동시,응진일보가강대성년인적을간역묘면역책략.
Objective To study the relationship on the prevalence rate of hepatitis B virus (HBV) infection and hepatitis B vaccination in urban citizens aged over 20 years old which would led to the development of strategies on HBV control. Methods A total of 3744 subjects from general population were randomly selected in this study. Both ELISA and radio immunoassay were used to test five items of HBV infection, including HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc. Results The overall standardized infection rate of HBV was 51.7%, and HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 4.5%,48.5 %, 0.3 %, 3.5 % and 51.4 %, respectively. The two lowest HBsAg positive rates were found in the groups under 30 years old (2.9%) and students (2.6%). Anti-HBc rate among men was significantly higher than seen in women (P<0.05), and showing a trend of increase with age (χ2> for trend= 256.2,P<0.001 ). The standardized rates of HB vaccination in this population was 17.6% and decreasing rapidly with age (P<0.05). People who had been vaccinated had both lower rates of HBsAg and HBV infection but higher rate of anti-HBs than those who had not (P<0.05). Conclusion liB vaccination in adults showed a reducing rate of HBV infection in the general population. Together with the enhancement of expanded program on immunization to wards HB vaccination in neonates, much attention should be paid to HB vaccination in adults.
