CAJ | 학술논문

目的探讨高甘油三酯性腰围(HTGW)对糖尿病发病的独立影响以及HTGW与空腹血糖受损(IFG)在糖尿病发病上是否存在交互作用.方法采用队列研究的方法,以“江苏省多代谢异常和代谢综合征综合防治研究队列”资料为基础,运用logistic回归模型分析HTGW和IFG与糖尿病的关系以及评价HTGW与IFG之间的相乘交互作用；采用引入Andersson等编制的Excel表计算相加交互作用.结果调整糖尿病的一般危险因素及基线空腹血糖(FPG)后,HTGW患者发生糖尿病的HR值为2.10(95％CI:1.36 ～ 3.25).进一步以IFG分层分析发现,无论是IFG组还是FPG正常组,HTGW均与糖尿病存在显著的联系,HR值及95％CI分别为3.09(1.70～5.61)和2.09(1.08～4.02).将HTGW和IFG交叉分析发现,与非HTGW表型的非IFG对象相比,基线时HTGW表型的IFG患者发生糖尿病的风险最高,HR值及95％CI为12.05(6.89～21.07).交互作用分析表明HTGW和IFG之间存在致糖尿病的相加交互作用,相对超危险度为7.00(0.49～ 13.51),交互作用归因比为0.57(0.32～0.82),交互作用指数为2.66(1.36～ 5.21).结论 HTGW具有独立于IFG预测糖尿病发病的作用,HTGW与IFG同时存在时具有致糖尿病的相加交互作用.
목적 탐토고감유삼지성요위(HTGW)대당뇨병발병적독립영향이급HTGW여공복혈당수손(IFG)재당뇨병발병상시부존재교호작용.방법 채용대렬연구적방법,이“강소성다대사이상화대사종합정종합방치연구대렬”자료위기출,운용logistic회귀모형분석HTGW화IFG여당뇨병적관계이급평개HTGW여IFG지간적상승교호작용；채용인입Andersson등편제적Excel표계산상가교호작용.결과 조정당뇨병적일반위험인소급기선공복혈당(FPG)후,HTGW환자발생당뇨병적HR치위2.10(95％CI:1.36 ～ 3.25).진일보이IFG분층분석발현,무론시IFG조환시FPG정상조,HTGW균여당뇨병존재현저적련계,HR치급95％CI분별위3.09(1.70～5.61)화2.09(1.08～4.02).장HTGW화IFG교차분석발현,여비HTGW표형적비IFG대상상비,기선시HTGW표형적IFG환자발생당뇨병적풍험최고,HR치급95％CI위12.05(6.89～21.07).교호작용분석표명HTGW화IFG지간존재치당뇨병적상가교호작용,상대초위험도위7.00(0.49～ 13.51),교호작용귀인비위0.57(0.32～0.82),교호작용지수위2.66(1.36～ 5.21).결론 HTGW구유독립우IFG예측당뇨병발병적작용,HTGW여IFG동시존재시구유치당뇨병적상가교호작용.
Objective To study the use ofhypertriglyceridemic waist (HTGW) to predict the occurrence of diabetes.Also to independently study whether there was an interaction between HTGW and impaired fasting glucose impaired fasting glucose (IFG) on the cause of diabetes.Methods We undertook a cohort study based on data from the “Prevention of Multiple Metabolic Disorders and Metabolic Syndrome (MS) Study in Jiangsu Province,China”.We used the logistic regression model to analyze the relations between both HTGW,IFG and diabetes mellitus and to evaluate the multiplied interaction between HTGW and IFG to include product terms method.Counting additive interaction was carried out under the Excel Calculation Sheet,compiled by Anderson and his colleagues.Results After adjusted for general risk factors and baseline fasting plasma glucose (FPG),results showed that subjects with HTGW had a 2.10 (95％ CI:1.36-3.25) adjusted relative risk (HR) of developing a diabetes when compared with those individuals without HTGW at the baseline study.When IFG was stratified,participants with HTGW were significantly associated with diabetes,regardless of IFG.The multi-adjusted HRs of diabetes were 3.09 (1.70-5.61) and 2.09 (1.08-4.02),respectively.Compared to the participants with non-HTGW and their FPG level below the threshold,those having HTGW and their FPG level was above the threshold,had the highest adjusted HR values [12.05 (95％CI:6.89-21.07)].Data from the additive interaction analysis showed that RERI as 7.00 (95％ CI:0.49-13.51),AP as 0.57 (95％ CI:0.32-0.82) and SI as 2.66 (95％ CI:1.36-5.21).Conclusion HTGW could predict the occurrence of diabetes,independent from IFG while the presence of HTGW with IFG could have an additive interaction on the cause of diabetes.