中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
2期
114-119
,共6页
靳子义%韩仁强%张晓峰%王旭善%武鸣%张作风%赵金扣
靳子義%韓仁彊%張曉峰%王旭善%武鳴%張作風%趙金釦
근자의%한인강%장효봉%왕욱선%무명%장작풍%조금구
肺肿瘤%绿茶%大蒜%病例对照研究
肺腫瘤%綠茶%大蒜%病例對照研究
폐종류%록다%대산%병례대조연구
Lung neoplasia%Green tea%Garlic%Case-control study
目的 分析江苏省恶性肿瘤低发区赣榆县饮用绿茶、食用大蒜等与肺癌相关的主要因素及其交互作用.方法 开展以人群为基础的病例对照研究,面对面询问收集主要人口学及与肺癌发生可能有关的行为、环境和饮食等资料.采用非条件logistic回归方法计算比值比(OR)及其95％CI,并进行单因素和调整可能混杂因素的多因素数据分析.结果 饮用绿茶(OR=0.78,95％CI:0.65 ～ 0.95)、食用大蒜(0R=0.79,95％CI:0.66 ～ 0.95)及同时饮用绿茶和食用大蒜(OR=0.69,95％CI:0.53 ～ 0.89)与肺癌发生呈负性关联,并均减弱吸烟、油炸食物、炒菜油温等危险因素与肺癌发生的正性关联.不食用大蒜与吸烟存在相加交互作用,超额相对危险度(RERI)、交互作用归因比(AP)和交互作用指数(SI)分别为0.86、0.26和1.61；不饮用绿茶与炒菜油温低同时存在相加交互作用(RERI=-0.58,AP=-0.47,SI=0.30)和相乘交互作用(OR=0.64,95％CI:0.43 ～0.95).结论 饮用绿茶和食用大蒜可能是肺癌发生的保护因素.
目的 分析江囌省噁性腫瘤低髮區贛榆縣飲用綠茶、食用大蒜等與肺癌相關的主要因素及其交互作用.方法 開展以人群為基礎的病例對照研究,麵對麵詢問收集主要人口學及與肺癌髮生可能有關的行為、環境和飲食等資料.採用非條件logistic迴歸方法計算比值比(OR)及其95％CI,併進行單因素和調整可能混雜因素的多因素數據分析.結果 飲用綠茶(OR=0.78,95％CI:0.65 ～ 0.95)、食用大蒜(0R=0.79,95％CI:0.66 ～ 0.95)及同時飲用綠茶和食用大蒜(OR=0.69,95％CI:0.53 ～ 0.89)與肺癌髮生呈負性關聯,併均減弱吸煙、油炸食物、炒菜油溫等危險因素與肺癌髮生的正性關聯.不食用大蒜與吸煙存在相加交互作用,超額相對危險度(RERI)、交互作用歸因比(AP)和交互作用指數(SI)分彆為0.86、0.26和1.61；不飲用綠茶與炒菜油溫低同時存在相加交互作用(RERI=-0.58,AP=-0.47,SI=0.30)和相乘交互作用(OR=0.64,95％CI:0.43 ～0.95).結論 飲用綠茶和食用大蒜可能是肺癌髮生的保護因素.
목적 분석강소성악성종류저발구공유현음용록다、식용대산등여폐암상관적주요인소급기교호작용.방법 개전이인군위기출적병례대조연구,면대면순문수집주요인구학급여폐암발생가능유관적행위、배경화음식등자료.채용비조건logistic회귀방법계산비치비(OR)급기95％CI,병진행단인소화조정가능혼잡인소적다인소수거분석.결과 음용록다(OR=0.78,95％CI:0.65 ～ 0.95)、식용대산(0R=0.79,95％CI:0.66 ～ 0.95)급동시음용록다화식용대산(OR=0.69,95％CI:0.53 ～ 0.89)여폐암발생정부성관련,병균감약흡연、유작식물、초채유온등위험인소여폐암발생적정성관련.불식용대산여흡연존재상가교호작용,초액상대위험도(RERI)、교호작용귀인비(AP)화교호작용지수(SI)분별위0.86、0.26화1.61；불음용록다여초채유온저동시존재상가교호작용(RERI=-0.58,AP=-0.47,SI=0.30)화상승교호작용(OR=0.64,95％CI:0.43 ～0.95).결론 음용록다화식용대산가능시폐암발생적보호인소.
Objective To understand the relationship between green tea drinking and/or garlic consumption and lung cancer.Methods A population-based case-control study was conducted in Ganyu county,Jiangsu province.Epidemiological data including demography,lifestyle,environmental exposures and dietary habits were collected by face-to-face interviews using a standardized questionnaire.Unconditional logistic regression was used to estimate adjusted odds ratios (OR) and their 95％ confidence intervals (CI) in both univariate and multivariate analyses.Results Both green tea drinking and garlic consumption were inversely associated with lung cancer and the adjusted ORs were:0.78 (95％CI:0.65-0.95) for green tea,0.79 (95％ CI:0.66-0.95) for garlic intake,and 0.69 (95％CI:0.53-0.89) for both,respectively.They also modified the associations of smoking,fried food intake and cooking oil under high-temperature with lung cancer as risk factors.Potential interactions were found between garlic or green tea and the risk factors of lung cancer.Conclusion Both green tea drinking and garlic consumption might serve as protective factors on lung cancer.
