中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
3期
214-217
,共4页
孙爱武%毕胜利%王锋%王富珍%张爽%涂秋风%邵晓萍%郑徽%孙校金
孫愛武%畢勝利%王鋒%王富珍%張爽%塗鞦風%邵曉萍%鄭徽%孫校金
손애무%필성리%왕봉%왕부진%장상%도추풍%소효평%정휘%손교금
乙型肝炎病毒表面抗原%配偶%基因型%风险
乙型肝炎病毒錶麵抗原%配偶%基因型%風險
을형간염병독표면항원%배우%기인형%풍험
HBsAg%Spouse%Genotype%Risk
目的 探讨乙型肝炎(乙肝)病毒(HBV)表面抗原(HBsAg)携带者配偶感染HBV危险性,为制定乙肝相关防控策略提供参考依据.方法 选择广东和江西省2006年全国乙肝血清流行病学调查发现的20 ～ 45岁HBsAg携带者及配偶作为病例组,运用病例对照方法按居住地、性别、年龄及婚龄等因素配比选择HBsAg阴性者及配偶为对照组,开展问卷调查和乙肝血清学指标检测.利用PCR方法分析夫妻双方均HBsAg阳性的HBV基因型.结果 HBsAg携带者配偶HBsAg携带率为13.21％,明显高于对照组配偶(6.29％),差异有统计学意义(x2=4.23,P＜0.05);HBsAg携带者其配偶的携带率均高于HBsAg阴性者的配偶;HBsAg携带者配偶的HBsAg携带率与结婚年限、性生活频率呈正相关,并与安全性行为关系密切.21对HBsAg均阳性的夫妻中,13对PCR扩增HBV阳性,其中11对(84.62％)HBV基因型相同(8对HBV为B型,3对为C型),仅2对夫妻HBV基因型不同.结论 HBsAg携带者配偶感染HBV风险高;提倡HBsAg携带者主动告知配偶,采取安全性行为或配偶及时接种乙肝疫苗等有效措施.
目的 探討乙型肝炎(乙肝)病毒(HBV)錶麵抗原(HBsAg)攜帶者配偶感染HBV危險性,為製定乙肝相關防控策略提供參攷依據.方法 選擇廣東和江西省2006年全國乙肝血清流行病學調查髮現的20 ～ 45歲HBsAg攜帶者及配偶作為病例組,運用病例對照方法按居住地、性彆、年齡及婚齡等因素配比選擇HBsAg陰性者及配偶為對照組,開展問捲調查和乙肝血清學指標檢測.利用PCR方法分析伕妻雙方均HBsAg暘性的HBV基因型.結果 HBsAg攜帶者配偶HBsAg攜帶率為13.21％,明顯高于對照組配偶(6.29％),差異有統計學意義(x2=4.23,P＜0.05);HBsAg攜帶者其配偶的攜帶率均高于HBsAg陰性者的配偶;HBsAg攜帶者配偶的HBsAg攜帶率與結婚年限、性生活頻率呈正相關,併與安全性行為關繫密切.21對HBsAg均暘性的伕妻中,13對PCR擴增HBV暘性,其中11對(84.62％)HBV基因型相同(8對HBV為B型,3對為C型),僅2對伕妻HBV基因型不同.結論 HBsAg攜帶者配偶感染HBV風險高;提倡HBsAg攜帶者主動告知配偶,採取安全性行為或配偶及時接種乙肝疫苗等有效措施.
목적 탐토을형간염(을간)병독(HBV)표면항원(HBsAg)휴대자배우감염HBV위험성,위제정을간상관방공책략제공삼고의거.방법 선택엄동화강서성2006년전국을간혈청류행병학조사발현적20 ～ 45세HBsAg휴대자급배우작위병례조,운용병례대조방법안거주지、성별、년령급혼령등인소배비선택HBsAg음성자급배우위대조조,개전문권조사화을간혈청학지표검측.이용PCR방법분석부처쌍방균HBsAg양성적HBV기인형.결과 HBsAg휴대자배우HBsAg휴대솔위13.21％,명현고우대조조배우(6.29％),차이유통계학의의(x2=4.23,P＜0.05);HBsAg휴대자기배우적휴대솔균고우HBsAg음성자적배우;HBsAg휴대자배우적HBsAg휴대솔여결혼년한、성생활빈솔정정상관,병여안전성행위관계밀절.21대HBsAg균양성적부처중,13대PCR확증HBV양성,기중11대(84.62％)HBV기인형상동(8대HBV위B형,3대위C형),부2대부처HBV기인형불동.결론 HBsAg휴대자배우감염HBV풍험고;제창HBsAg휴대자주동고지배우,채취안전성행위혹배우급시접충을간역묘등유효조시.
Objective To investigate the risk of HBV infection among the spouses of hepatitis B virus surface antigen (HBsAg) carriers and to provide a reference for developing strategies on hepatitis B control and prevention.Methods A case-control study including HBsAg carriers aged 20-45 years-old from the nationwide sero-epidemiological survey for Hepatitis B in both Guangdong and Jiangxi provinces in 2006,together with their spouses were selected as case group,while.HBsAg negative persons and their spouses were among the control groups,under the same residencial areas,gender,age and age of marriage to the HBsAg carriers.Questionnaire survey and hepatitis B serological markers detection were carried out,together with the HBV genotype detection among the HBsAg positive couples between husband and wife by PCR.Results Among the spouses of HBsAg carriers,the positive rate of HBsAg was 13.21％,while the rate was 6.29％ for the spouse of HBsAg negative population,with difference statistically significant (x2=4.23,P＜ 0.05).HBsAg positive rate among spouses of the case group was higher than that in the control group.Among the spouses of HBsAg carriers,the HBsAg rate was positively correlated with the age of marriage,frequency of sexual intercourse and condom use.There were 21 pairs of HBsAg carriers between husband and wife,and HBV were isolated among 13 pairs,and there were 11 pairs carrying the same HBV genotype,accounting for 84.62％.HBV genotypes would include 8 pairs of type B and 3 pairs of type C.However,only 2 pairs were infected with different HBV genotype.Conclusion High risks of HBV infection existed in the spouses of HBsAg carriers.It was important to ask the HBsAg carriers to take the initiative in informing their spouses,and carrying out the appropriate measures,such as safe sex or timely hepatitis B vaccination for the spouse of HBsAg carriers etc.,so as to reduce the HBV transmission between husband and wife.
