CAJ | 학술논문

目的探讨有机阳离子转运体基因两个分型(OCTN1/2)的基因多态性与克罗恩病(CD)易感性的关系.方法检索PubMed、EMBASE、MedLine、CNKI和万方数据库,同时手工检索所有纳入文献的参考文献,收集截止至2012年9月关于OCTN1/2基因多态性与CD易感性的病例对照研究,统计分析采用Review Manager 4.2软件和Stata 10.0软件.结果检索文献中纳入19篇病例对照研究.总的分析表明,OCTN1/2基因多态性与CD易感性相关;按地区分层分析,欧洲人群OCTN 1/2基因多态性与CD易感性相关,非欧洲人群OCTN1基因(TT vs.CT:OR=1.25,95％CI:0.75～1.98,P=0.34;TTvs.CC+CT:OR=1.48,95％CI:0.95～2.29,P=0.08)、OCTN2基因(CC vs.GC:OR=1.03,95％CI:0.68～1.56,P=0.89; CC vs.GG+GC:OR=1.23,95％CI:0.83～1.82,P=0.31)基因频率差异无统计学意义,但OCTN1基因(TTvs.CC与TT+CTvs.CC)、OCTN2基因(CCvs.GG与CC+ GCvs.GG)基因频率差异有统计学意义.结论欧洲人群中,有机阳离子转运体OCTN1/2基因多态性与CD易感性相关,而非欧洲人群其易感性的关系仍需大样本的研究结果证实.
목적 탐토유궤양리자전운체기인량개분형(OCTN1/2)적기인다태성여극라은병(CD)역감성적관계.방법 검색PubMed、EMBASE、MedLine、CNKI화만방수거고,동시수공검색소유납입문헌적삼고문헌,수집절지지2012년9월관우OCTN1/2기인다태성여CD역감성적병례대조연구,통계분석채용Review Manager 4.2연건화Stata 10.0연건.결과 검색문헌중납입19편병례대조연구.총적분석표명,OCTN1/2기인다태성여CD역감성상관;안지구분층분석,구주인군OCTN 1/2기인다태성여CD역감성상관,비구주인군OCTN1기인(TT vs.CT:OR=1.25,95％CI:0.75～1.98,P=0.34;TTvs.CC+CT:OR=1.48,95％CI:0.95～2.29,P=0.08)、OCTN2기인(CC vs.GC:OR=1.03,95％CI:0.68～1.56,P=0.89; CC vs.GG+GC:OR=1.23,95％CI:0.83～1.82,P=0.31)기인빈솔차이무통계학의의,단OCTN1기인(TTvs.CC여TT+CTvs.CC)、OCTN2기인(CCvs.GG여CC+ GCvs.GG)기인빈솔차이유통계학의의.결론 구주인군중,유궤양리자전운체OCTN1/2기인다태성여CD역감성상관,이비구주인군기역감성적관계잉수대양본적연구결과증실.
Objective To investigate the associations between polymorphisms of organic cation transporter OCTN1/2 (organic cation transporter 1/2) and the susceptibility of Crohn' s disease (CD) through a meta-analysis.Methods Databases of PubMed,EMBASE,MedLine,and CNKI (Chinese),Wanfang (Chinese) were searched for published case control studies on the association between polymorphisms of OCTN1/2 gene and the susceptibility of CD which were published before September 2012.The meta-analysis was applied with Review Manager 4.2 software and Stata 10.0 software.Results Nineteen eligible studies,including 14 from Europeans,3 from Asians,1 from Oceania,and 1 from the US were included in the meta-analysis.In total,significant associations were found between OCTN1/2 polymorphisms and the susceptibility of CD for all genetic models.In subgroup analyses,significant associations were found in the European population for OCTN1/2.Associations were not significant in the non-European population for OCTN1 (TT vs.CT:OR=1.25,95％CI:0.75-1.98,P=0.34; TT vs.CC+CT:OR=l.48,95％CI:0.95-2.29,P=0.08) and for OCTN2 (CC vs.GC:OR=1.03,95％CI:0.68-1.56,P=0.89; CC vs.GG + GC:OR=1.23,95％CI:0.83-1.82,P=0.31).However,there were significant associations found between OCTN1/2(TT vs.CC,TT+CT vs.CC,CC vs.GG,CC + GC vs.GG) polymorphisms and the susceptibility of CD found in the nonEuropean population.Conclusion Results from this meta-analysis suggested that OCTN1/2 polymorphisms were associated with the susceptibility of CD in the European population.Associations between OCTN1/2 polymorphisms and the susceptibility of CD in the non-European population required searching for large samples to confirm the findings.