中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2013年
6期
566-568
,共3页
曹慧丽%吕滨%陈雄彪%鲁锦国%侯志辉%唐翔%高扬%于方方%陈阳
曹慧麗%呂濱%陳雄彪%魯錦國%侯誌輝%唐翔%高颺%于方方%陳暘
조혜려%려빈%진웅표%로금국%후지휘%당상%고양%우방방%진양
尿酸%冠状动脉钙化%自然人群
尿痠%冠狀動脈鈣化%自然人群
뇨산%관상동맥개화%자연인군
Uric acid%Coronary artery calcification%Natural population
目的 探讨自然人群血尿酸对冠状动脉钙化的影响.方法 2012年4-7月对903名(男37 ～ 76岁,女42～76岁)北京市西山社区人群进行心血管危险因素调查、血生化检查及CT冠状动脉钙化扫描.结果 尿酸水平位于第1四分位数(1 Q)、2～3Q、4Q人群的冠状动脉钙化率分别为37.2％、45.5％、60.6％(P＜0.001),冠状动脉钙化积分分别为(109.7±333.1)AU、(133.9±356.9)AU、(200.8±459.4)AU(P＜0.001).单因素logistic回归分析显示随尿酸水平升高冠状动脉钙化风险增加(2～3 Q:OR=1.41,95％CI:1.02～1.95,P=0.040；4 Q:OR=2.60,95％CI:1.78～3.80,P＜0.001),但多因素logistic回归分析中尿酸与冠状动脉钙化的关系消失(2～3 Q:OR=0.92,95％CI:0.60～ 1.43,P=0.713;4 Q:OR=1.38,95％CI:0.80～ 2.39,P=0.247).结论 北京市社区人群冠状动脉钙化率及钙化程度随尿酸水平升高而增加,但血尿酸水平并非冠状动脉钙化的独立危险因素.
目的 探討自然人群血尿痠對冠狀動脈鈣化的影響.方法 2012年4-7月對903名(男37 ～ 76歲,女42～76歲)北京市西山社區人群進行心血管危險因素調查、血生化檢查及CT冠狀動脈鈣化掃描.結果 尿痠水平位于第1四分位數(1 Q)、2～3Q、4Q人群的冠狀動脈鈣化率分彆為37.2％、45.5％、60.6％(P＜0.001),冠狀動脈鈣化積分分彆為(109.7±333.1)AU、(133.9±356.9)AU、(200.8±459.4)AU(P＜0.001).單因素logistic迴歸分析顯示隨尿痠水平升高冠狀動脈鈣化風險增加(2～3 Q:OR=1.41,95％CI:1.02～1.95,P=0.040；4 Q:OR=2.60,95％CI:1.78～3.80,P＜0.001),但多因素logistic迴歸分析中尿痠與冠狀動脈鈣化的關繫消失(2～3 Q:OR=0.92,95％CI:0.60～ 1.43,P=0.713;4 Q:OR=1.38,95％CI:0.80～ 2.39,P=0.247).結論 北京市社區人群冠狀動脈鈣化率及鈣化程度隨尿痠水平升高而增加,但血尿痠水平併非冠狀動脈鈣化的獨立危險因素.
목적 탐토자연인군혈뇨산대관상동맥개화적영향.방법 2012년4-7월대903명(남37 ～ 76세,녀42～76세)북경시서산사구인군진행심혈관위험인소조사、혈생화검사급CT관상동맥개화소묘.결과 뇨산수평위우제1사분위수(1 Q)、2～3Q、4Q인군적관상동맥개화솔분별위37.2％、45.5％、60.6％(P＜0.001),관상동맥개화적분분별위(109.7±333.1)AU、(133.9±356.9)AU、(200.8±459.4)AU(P＜0.001).단인소logistic회귀분석현시수뇨산수평승고관상동맥개화풍험증가(2～3 Q:OR=1.41,95％CI:1.02～1.95,P=0.040；4 Q:OR=2.60,95％CI:1.78～3.80,P＜0.001),단다인소logistic회귀분석중뇨산여관상동맥개화적관계소실(2～3 Q:OR=0.92,95％CI:0.60～ 1.43,P=0.713;4 Q:OR=1.38,95％CI:0.80～ 2.39,P=0.247).결론 북경시사구인군관상동맥개화솔급개화정도수뇨산수평승고이증가,단혈뇨산수평병비관상동맥개화적독립위험인소.
Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population (aged 37-76 years for men,aged 42-76 years for women) in Xishan community,Beijing,were selected to accept a survey on the risk factors of cardiovascular.Blood tests and CT coronary artery calcium scans were carried out.Results At the 1 Quartile (1 Q),2 to 3 Quartile (2-3 Q) and 4 Quartile (4 Q) of uric acid levels,the prevalence rates of coronary artery calcium were 37.2％,45.5％,60.6％ (P＜0.001) and the coronary artery calcium scores were (1 09.7 ± 333.1)AU,(133.9 ± 356.9) AU,(200.8 ± 459.4) AU(P＜0.001) respectively.Data from the univariate logistic regression analysis showed that with the increase of uric acid,the prevalence rates of coronary artery calcium also increased (OR2-3Q=1.41,95％ CI:1.02-1.95,P=0.040; OR4Q=2.60,95％ CI:1.78-3.80,P＜0.001).However,the relationship between uric acid and coronary artery calcium disappeared when using the multivariate logistic regression analysis (OR2-3Q=0.92,95％CI:0.60-1.43,P=0.713; OR4Q=l.38,95％ CI:0.80-2.39,P=0.247).Conclusion Uric acid did not seem to be an independent risk factor for coronary artery calcium,although the prevalence and extent of coronary artery calcium increased along with the increasing trend of uric acid.
