CAJ | 학술논문

目的探讨先天性消化道畸形发病的影响因素,为预防先天性消化道畸形发病提供参考.方法采用以医院为基础的病例对照研究方法,对2011年4月至2012年8月在湖南省儿童医院住院的120例先天性消化道畸形患儿及同期同科室住院的170例非先天性消化道畸形患儿父母进行问卷调查,数据分析采用SPSS 18.0软件.结果先天性消化道畸形与母亲孕前3个月内或孕期服用药物(OR=3.35,95％CI:1.51 ～ 7.41)、服用叶酸(OR=0.28,95％CI:0.15～ 0.52)、接触油性漆(OR=5.05,95％CI:1.32 ～ 19.29)、接触农药(OR=15.20,95％CI:1.55～ 148.99)及母亲孕前短期内患儿父亲服用药物(OR=3.70,95％CI:1.13～ 12.10)、吸烟(OR=2.39,95％CI=1.24～ 4.62)、饮酒(OR=2.47,95％CI:1.20 ～ 5.07)、接触室内清洗剂(OR=16.42,95％CI:1.71～157.92)、接触油性漆(OR=9.92,95％CI:2.66 ～ 36.98)有关.结论先天性消化道畸形的发生受多种环境因素影响,其中母亲孕前短期内或孕期服用药物、接触油性漆、接触农药、母亲孕前短期内患儿父亲服用药物、吸烟、饮酒、接触室内清洗剂为危险因素,母亲孕前短期内或孕期服用叶酸为保护因素.
목적 탐토선천성소화도기형발병적영향인소,위예방선천성소화도기형발병제공삼고.방법 채용이의원위기출적병례대조연구방법,대2011년4월지2012년8월재호남성인동의원주원적120례선천성소화도기형환인급동기동과실주원적170례비선천성소화도기형환인부모진행문권조사,수거분석채용SPSS 18.0연건.결과 선천성소화도기형여모친잉전3개월내혹잉기복용약물(OR=3.35,95％CI:1.51 ～ 7.41)、복용협산(OR=0.28,95％CI:0.15～ 0.52)、접촉유성칠(OR=5.05,95％CI:1.32 ～ 19.29)、접촉농약(OR=15.20,95％CI:1.55～ 148.99)급모친잉전단기내환인부친복용약물(OR=3.70,95％CI:1.13～ 12.10)、흡연(OR=2.39,95％CI=1.24～ 4.62)、음주(OR=2.47,95％CI:1.20 ～ 5.07)、접촉실내청세제(OR=16.42,95％CI:1.71～157.92)、접촉유성칠(OR=9.92,95％CI:2.66 ～ 36.98)유관.결론 선천성소화도기형적발생수다충배경인소영향,기중모친잉전단기내혹잉기복용약물、접촉유성칠、접촉농약、모친잉전단기내환인부친복용약물、흡연、음주、접촉실내청세제위위험인소,모친잉전단기내혹잉기복용협산위보호인소.
Objective To investigate the influential factors on congenital gastrointestinal malformation and to provide evidences for prevention.Methods A hospital-based case-control study was conducted among infants with or without congenital gastrointestinal malformation at Children's hospital of Hunan province,from April 2011 to August 2012.Parents of 120 cases with congenital gastrointestinal malformation and another 170 controls were asked to fill in a questionnaire.Data was analyzed using SPSS 18.0 software.Results Congenital gastrointestinal malformation was associated with intakes of maternal medication (OR=3.35,95％CI:1.51-7.41) and folic acid (OR=0.28,95％CI:0.15-0.52),exposure to paints (OR=5.05,95％CI:1.32-19.29) and pesticides (OR=15.20,95％CI:1.55-148.99) prior to or during pregnancy,and also associated with medication intake of the father (OR=3.70,95％CI:1.13-12.10),smoking (OR=2.39,95％CI:1.24-4.62),drinking alcohol (OR=2.47,95％CI:1.20-5.07),exposure to the agents for indoor cleaning (OR=16.42,95％ CI:1.71-157.92) and exposure to paints (OR=9.92,95％ CI:2.66-36.98) before conception.Conclusion Congenital gastrointestinal malformation was affected by multiple factors.Potential risk factors for congenital gastrointestinal malformation would include intakes of medication by the pregnant mother,exposure to paints exposure and pesticide exposure before or during pregnancy,and medication intake by the father,smoking,drinking alcohol,exposure to indoor cleaning agents/paint before conception.The amount of folic acid intake by mother before or during pregnancy was likely to reduce the risk for congenital gastrointestinal malformation.