CAJ | 학술논문

目的掌握1990-2012年广东省登革热和基孔肯雅热感染状况和流行态势.方法采用回顾性调查及文献研究相结合的方法获取1990-2012年广东省登革热和基孔肯雅热疫情及病原学监测资料,采集健康人群血清进行登革病毒(DENV)和基孔肯雅病毒(CHIKV)-IgG特异性抗体检测.结果 1995、2002、2006年广东省出现3个登革热流行高峰,发病率分别为9.75/10万、1.76/10万、1.25/10万.1990-1994年优势毒株为DENV-2和DENV-4型;1995年开始DENV-1型主导的流行模式持续近13年;2009年开始多种血清型合并流行.2003-2012年从7 718份健康人血清中检出DENV-IgG特异性抗体阳性标本180份,阳性率2.33％;2012年对采集的2 132份健康人血清进行CHIKV-IgG特异性抗体检测,结果均为阴性.结论广东省登革热感染水平总体较低,近年来由DENV-1型主导的流行模式逐步向多型并存的局面过渡,部分地区开始呈现地方化迹象.人群对CHIKV缺乏基本的免疫屏障,应加强监测与防控.
목적 장악1990-2012년광동성등혁열화기공긍아열감염상황화류행태세.방법 채용회고성조사급문헌연구상결합적방법획취1990-2012년광동성등혁열화기공긍아열역정급병원학감측자료,채집건강인군혈청진행등혁병독(DENV)화기공긍아병독(CHIKV)-IgG특이성항체검측.결과 1995、2002、2006년광동성출현3개등혁열류행고봉,발병솔분별위9.75/10만、1.76/10만、1.25/10만.1990-1994년우세독주위DENV-2화DENV-4형;1995년개시DENV-1형주도적류행모식지속근13년;2009년개시다충혈청형합병류행.2003-2012년종7 718빈건강인혈청중검출DENV-IgG특이성항체양성표본180빈,양성솔2.33％;2012년대채집적2 132빈건강인혈청진행CHIKV-IgG특이성항체검측,결과균위음성.결론 광동성등혁열감염수평총체교저,근년래유DENV-1형주도적류행모식축보향다형병존적국면과도,부분지구개시정현지방화적상.인군대CHIKV결핍기본적면역병장,응가강감측여방공.
Objective To understand the status of infection and epidemic trend of Dengue fever and Chikungunya in Guangdong.Methods Retrospective survey and literature review were used to obtain data on the incidence,etiology of Dengue and Chikungunya.Serological survey was conducted to detect the specific-antibodies in healthy individuals for both Dengue virus (DENV) and Chikungunya virus (CHIKV).Results Three epidemics of Dengue fever were observed during 1990-2012,with the annual incidence rates as 9.75/100 000 in 1995,1.76/100 000 in 2002 and 1.25/100 000 in 2006,respectively.The predominant epidemic strains appeared to be DENV-2 and DENV-4 during 1990-1994.Since 1995,DENV-1 had become the predominant transmission strain which lasted for almost 13 years.Co-existence of multiple serotypes of DENV started in 2009.Of the 7 718 sera from healthy population during 2003-2012,180 specimens were detected positive for specific DENV-IgG antibody,ended with a sero-prevalence rate of 2.33％.All 2 132 sera in 2012 were detected negative for CHIKV-IgG antibody.Conclusion The overall exposure level to Dengue was considered to be low in Guangdong province.However,the predominant transmission mode caused by DENV-1 had been gradually changed into the co-existence of multiple serotypes with the endemic signs appeared in some part of the areas.Chikungunya was a newly emerging disease in Guangdong since local people were lack of basic immunity barrier.Surveillance and control programs thus seemed important.